DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8272 and B0393.3

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_497980.1	Gene:	B0393.3 / 175630	WormBaseID:	WBGene00007168	Length:	621	Species:	Caenorhabditis elegans

Alignment Length:	551	Identity:	110/551 - (19%)
Similarity:	201/551 - (36%)	Gaps:	193/551 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 HFLFEDV---------TLGQVKELMRFMGRTAQSLALDNVDLNDKQFYGMLGVLPHLHSLSLKRC 137
            ||..:|:         .|.|:|:       :...:.:::|.|.|:    :|.:.|..|.||
Worm    18 HFSLQDLRDDEFVQNSALLQLKD-------SILDIIVEHVPLKDR----LLKLRPVCHRLS---- 67

  Fly   138 LPLFMSGSFLDSYNNSCPDLNDLASNLAGIKELTLCENQYLTDAILMRLTSFMPSLEAINMSGCH 202
                      ||...|...:..|..      ||..|::                         ..
Worm    68 ----------DSVKRSVKSVEFLRD------ELDYCDD-------------------------AK 91

  Fly   203 IAFHNAIHRRFYPATSSSDHVLPSESVLTFKFILTILNLQRRTLRVLNFSHTLIGQALLALCDLN 267
            |:|..|::.:                           |:|.     :|:.       |...|.|.
Worm    92 ISFFLAVYGK---------------------------NVQH-----MNYD-------LFRSCSLR 117

  Fly   268 LQLQRLYLAGCRQLNCTTILNFLATQPQLCALDLSATMC----VNDENLAALVQTNPQLEHLKVN 328
            ...|..:    ||    ::::.:...|||..||:  .:|    :.|.:|..:.:...|||.|:::
Worm   118 EYTQWSW----RQ----SVISSVTRCPQLKQLDI--LICCRHRLRDGDLQVIFKQCNQLEELRMD 172

  Fly   329 GCLSITNAGAIHLAKLKCLKSLDISNCDNLTSSGIIEGIASEENPVIQELNVSYLQ-ICEECIKA 392
            .  |..|......|. :.|:.|::..|..|...|.| |:.|.... :|.|:||.:| |.|:.||.
Worm   173 A--SYINGHCFSKAP-QTLRKLELECCQTLNKQGFI-GMCSRLFK-LQTLHVSLMQCIDEQLIKR 232

  Fly   393 IASNLRCLRSLHLNHCVNGATDEAIQSVIGQLRWLRELS---LEHCSGLTDAALTGINISKLEMS 454
            | .:::.|::|.:   |.....:..|..:.::|.|.:|:   |:..:.:||..|..::    ::|
Worm   233 I-GDMKSLKNLSV---VADPDQKMNQFRLAEIRRLSKLTTLCLDGVNNVTDKFLGDLS----DLS 289

  Fly   455 RKQSGSQVSSMDNFYPPYSNTLAERDSLAGSLQSIKISLRSKAEDEIVRDARRKQAMLAAYEMNL 519
            ...:||.:..:..             |...::.|..||
Worm   290 TSPAGSSIEHLSL-------------SFCKNIGSNGIS--------------------------- 314

  Fly   520 IREDDFEGHNIQQLRGLRSLNLRGCNKISDVSLKYGLKHI----ELRRLMLSNCQQISLLGMEAM 580
                     .::.|..|:||||.|.:| .|:|.  ||:.|    .|.||::|....::...:...
Worm   315 ---------KLKTLPNLKSLNLDGVSK-RDIST--GLEAIGQAGRLERLLVSEDTYVNPKTIAEF 367

  Fly   581 ASSCPSIEELDLSDCYNITDKTI--QVVTSK 609
            .::|.|:..||:|..:.:.||:.  ||.:::
Worm   368 VNTCESLRTLDISGNHRLKDKSFAEQVYSAR 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	44/178 (25%)
		leucine-rich repeat	270..295	CDD:275381	3/24 (13%)
		leucine-rich repeat	296..319	CDD:275381	6/26 (23%)
		leucine-rich repeat	322..346	CDD:275381	6/23 (26%)
		leucine-rich repeat	347..399	CDD:275381	18/52 (35%)
		leucine-rich repeat	400..426	CDD:275381	4/25 (16%)
		leucine-rich repeat	427..535	CDD:275381	14/110 (13%)
		AMN1	515..>642	CDD:187754	26/101 (26%)
		leucine-rich repeat	536..560	CDD:275381	12/27 (44%)
		leucine-rich repeat	561..586	CDD:275381	5/24 (21%)
		leucine-rich repeat	587..612	CDD:275381	7/25 (28%)
		leucine-rich repeat	613..638	CDD:275381
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381	7/36 (19%)
		leucine-rich repeat	167..192	CDD:275381	3/24 (13%)
		leucine-rich repeat	193..244	CDD:275381	5/50 (10%)
		C2	<231..274	CDD:301316	7/42 (17%)
		leucine-rich repeat	246..269	CDD:275381	4/22 (18%)
B0393.3	NP_497980.1	leucine-rich repeat	103..137	CDD:275381	8/53 (15%)
		leucine-rich repeat	138..165	CDD:275381	6/28 (21%)
		leucine-rich repeat	188..213	CDD:275381	8/25 (32%)
		leucine-rich repeat	214..265	CDD:275381	16/54 (30%)
		LRR	232..>389	CDD:227223	42/216 (19%)
		AMN1	<262..408	CDD:187754	39/193 (20%)
		leucine-rich repeat	266..296	CDD:275381	7/33 (21%)
		leucine-rich repeat	297..321	CDD:275381	5/72 (7%)
		leucine-rich repeat	348..373	CDD:275381	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810