DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8272 and FBXL16

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_699181.2	Gene:	FBXL16 / 146330	HGNCID:	14150	Length:	479	Species:	Homo sapiens

Alignment Length:	519	Identity:	104/519 - (20%)
Similarity:	164/519 - (31%)	Gaps:	210/519 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 GVLPHLHSLSLKRCLP------LFMSGSFLDSYNNSCPDLNDLASNLAGIKELTLCE--NQY--- 177
            |:.|.||:..|...||      :.:.|.....:...|         |.|:.:|.:||  :.|
Human   136 GLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFC---------LVGVSDLDICEFIDNYALS 191

  Fly   178 -------------LTDAILMRLTSFMPSLEAINMSGCHIAFHNAIHRRFYPATSSSDHVLPSESV 229
                         :|||.|..:...|..:..:.:|||:
Human   192 KKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCN--------------------------- 229

  Fly   230 LTFKFILTILNLQRRTLRVLNFSHTLIGQALLALCDLNLQLQRLYLAGCRQLNCTTILNFLATQP 294
                                :|:...:..:|.|      ::..|.::.|..:....|.......|
Human   230 --------------------DFTEAGLWSSLSA------RITSLSVSDCINVADDAIAAISQLLP 268

  Fly   295 QLCALDLSATMCVNDENLAALVQTNPQLEH-LKVNGCLSITNAGAIHLA-KLKCLKSLDISNCDN 357
            .|..|.|.| ..|.|..||..........| |::..|..|||.|.:::. .|..|.:|.:|.|..
Human   269 NLAELSLQA-YHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSK 332

  Fly   358 LTSSGIIEGIASEENPVIQELNVSYLQICEECIKAIASNLRCLRSLHLNHCVNGATDEAIQSVIG 422
            :|..|                           ::.:|.|||.||||.|:.|.. .||.|::.|..
Human   333 VTDDG---------------------------VELVAENLRKLRSLDLSWCPR-ITDMALEYVAC 369

  Fly   423 QLRWLRELSLEHCSGLTDAALTGINISKLEMSRKQSGSQVSSMDNFYPPYSNTLAERDSLAGSLQ 487
            .|..|.||.|:.|..:||..|:                           |.:|::
Human   370 DLHRLEELVLDRCVRITDTGLS---------------------------YLSTMS---------- 397

  Fly   488 SIKISLRSKAEDEIVRDARRKQAMLAAYEMNLIREDDFEGHNIQQLRGLRSLNLRGCNKISDVSL 552
                                                           .||||.||.|.::.|
Human   398 -----------------------------------------------SLRSLYLRWCCQVQD--- 412

  Fly   553 KYGLKHI----ELRRLMLSNCQQISLLGMEAMASSCPSIEELDLSDCYNITDKTIQVVTSKLPR 612
             :||||:    .||.|.|:.|..::..|:..:. ....:|||:|::|...|.:..:..:..|||
Human   413 -FGLKHLLALGSLRLLSLAGCPLLTTTGLSGLV-QLQELEELELTNCPGATPELFKYFSQHLPR 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	46/172 (27%)
		leucine-rich repeat	270..295	CDD:275381	3/24 (13%)
		leucine-rich repeat	296..319	CDD:275381	8/22 (36%)
		leucine-rich repeat	322..346	CDD:275381	8/25 (32%)
		leucine-rich repeat	347..399	CDD:275381	9/51 (18%)
		leucine-rich repeat	400..426	CDD:275381	11/25 (44%)
		leucine-rich repeat	427..535	CDD:275381	10/107 (9%)
		AMN1	515..>642	CDD:187754	27/102 (26%)
		leucine-rich repeat	536..560	CDD:275381	12/27 (44%)
		leucine-rich repeat	561..586	CDD:275381	6/24 (25%)
		leucine-rich repeat	587..612	CDD:275381	7/24 (29%)
		leucine-rich repeat	613..638	CDD:275381	104/519 (20%)
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381	8/42 (19%)
		leucine-rich repeat	167..192	CDD:275381	9/42 (21%)
		leucine-rich repeat	193..244	CDD:275381	3/50 (6%)
		C2	<231..274	CDD:301316	3/42 (7%)
		leucine-rich repeat	246..269	CDD:275381	3/22 (14%)
FBXL16	NP_699181.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62
		AMN1	201..413	CDD:332986	70/381 (18%)
		leucine-rich repeat	220..243	CDD:275381	6/75 (8%)
		leucine-rich repeat	244..269	CDD:275381	3/24 (13%)
		LRR 1	244..266		3/21 (14%)
		LRR 2	267..290		9/23 (39%)
		leucine-rich repeat	270..295	CDD:275381	8/25 (32%)
		leucine-rich repeat	296..321	CDD:275381	8/24 (33%)
		LRR 3	319..343		7/50 (14%)
		leucine-rich repeat	322..347	CDD:275381	9/51 (18%)
		LRR 4	345..369		12/24 (50%)
		leucine-rich repeat	348..373	CDD:275381	11/25 (44%)
		LRR 5	371..395		10/50 (20%)
		leucine-rich repeat	374..398	CDD:275381	10/107 (9%)
		LRR 6	396..420		12/84 (14%)
		LRR 7	446..470		6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810