DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8272 and Fbxl14

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_598701.2	Gene:	Fbxl14 / 101358	MGIID:	2141676	Length:	400	Species:	Mus musculus

Alignment Length:	463	Identity:	115/463 - (24%)
Similarity:	193/463 - (41%)	Gaps:	135/463 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 AFHNAI--------H-RRFYPATSSSDHVLPSESVLTFKFILTILNLQRRTLRVLNFSHTLIGQA 259
            |:|.::        | ||..|:      :.||......:.: .||:|:|      :.|:.:.|.|
Mouse    39 AYHKSVWRGVEAKLHLRRANPS------LFPSLQARGIRRV-QILSLRR------SLSYVIQGMA 90

  Fly   260 LLALCDLNLQLQRLYLAGCRQLNCTTILN-FLATQPQLCALDLSATMCVNDENLAALVQTNPQLE 323
                     .::.|.|:||..|....:.: |:.....|.||:||....:.|.:|..:.|....||
Mouse    91 ---------NIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLE 146

  Fly   324 HLKVNGCLSITNAGAIHLA-KLKCLKSLDISNCDNLTSSGI--IEGI---ASEENPVIQELNVSY 382
            .|::.||.:|||.|.:.:| .|:.||||::.:|.:|:..||  :.|:   |:|....:::|.
Mouse   147 VLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLT--- 208

  Fly   383 LQICEECIKAIASNLRCLRSLHLNHCVNGATDEAIQSVIGQLRWLRELSLEHCSGLTDAALTGIN 447
            ||.|::           |..|.|.|...|.|.            ||.|:|..|.|::||.|  ::
Mouse   209 LQDCQK-----------LTDLSLKHISRGLTG------------LRLLNLSFCGGISDAGL--LH 248

  Fly   448 ISKLEMSRKQSGSQVSSMDNFYPPYSNTLAERDSLAGSLQSIKISLRSKAEDEIVRDARRKQAML 512
            :|.:                                |||:|
Mouse   249 LSHM--------------------------------GSLRS------------------------ 257

  Fly   513 AAYEMNLIREDDFEGHNIQQLRGLRSLNLRG-----CNKISDVSLKYGLKHIE-LRRLMLSNCQQ 571
                :||...|:.....|..| .:.||.|.|     |:|:.|.||.|..:.:: |:.|.|.:| .
Mouse   258 ----LNLRSCDNISDTGIMHL-AMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSC-H 316

  Fly   572 ISLLGMEAMASSCPSIEELDLSDCYNITDKTIQVVTSKLPRLKALHISGCSQLTEHTLDAIITNC 636
            ||..|:..|......:..|::..|..||||.::::...|.:|..:.:.||:::|:..|:. ||..
Mouse   317 ISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLER-ITQL 380

  Fly   637 SCLQTLSI 644
            .||:.|::
Mouse   381 PCLKVLNL 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	52/177 (29%)
		leucine-rich repeat	270..295	CDD:275381	6/25 (24%)
		leucine-rich repeat	296..319	CDD:275381	8/22 (36%)
		leucine-rich repeat	322..346	CDD:275381	11/24 (46%)
		leucine-rich repeat	347..399	CDD:275381	15/56 (27%)
		leucine-rich repeat	400..426	CDD:275381	6/25 (24%)
		leucine-rich repeat	427..535	CDD:275381	19/107 (18%)
		AMN1	515..>642	CDD:187754	39/132 (30%)
		leucine-rich repeat	536..560	CDD:275381	10/28 (36%)
		leucine-rich repeat	561..586	CDD:275381	8/24 (33%)
		leucine-rich repeat	587..612	CDD:275381	7/24 (29%)
		leucine-rich repeat	613..638	CDD:275381	7/24 (29%)
		leucine-rich repeat	639..663	CDD:275381	2/6 (33%)
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381
		leucine-rich repeat	167..192	CDD:275381
		leucine-rich repeat	193..244	CDD:275381	11/48 (23%)
		C2	<231..274	CDD:301316	7/42 (17%)
		leucine-rich repeat	246..269	CDD:275381	3/22 (14%)
Fbxl14	NP_598701.2	Required for down-regulation of SNAI1. /evidence=ECO:0000250	2..48		2/8 (25%)
		F-box-like	5..46	CDD:403981	2/6 (33%)
		AMN1	90..296	CDD:187754	73/303 (24%)
		leucine-rich repeat	92..118	CDD:275381	6/25 (24%)
		leucine-rich repeat	119..142	CDD:275381	8/22 (36%)
		LRR 1	144..163		9/18 (50%)
		leucine-rich repeat	145..170	CDD:275381	11/24 (46%)
		LRR 2	170..191		8/20 (40%)
		leucine-rich repeat	171..203	CDD:275381	11/31 (35%)
		LRR 3	203..225		8/35 (23%)
		leucine-rich repeat	204..229	CDD:275381	9/38 (24%)
		AMN1	228..395	CDD:187754	55/238 (23%)
		LRR 4	229..250		9/34 (26%)
		leucine-rich repeat	230..254	CDD:275381	10/57 (18%)
		LRR 5	254..275		8/49 (16%)
		leucine-rich repeat	255..280	CDD:275381	8/53 (15%)
		leucine-rich repeat	281..306	CDD:275381	8/24 (33%)
		leucine-rich repeat	307..331	CDD:275381	8/24 (33%)
		leucine-rich repeat	332..357	CDD:275381	7/24 (29%)
		leucine-rich repeat	358..382	CDD:275381	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910