DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8272 and fbxl4

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_031761765.1	Gene:	fbxl4 / 100490265	XenbaseID:	XB-GENE-961513	Length:	622	Species:	Xenopus tropicalis

Alignment Length:	424	Identity:	80/424 - (18%)
Similarity:	141/424 - (33%)	Gaps:	153/424 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YDDLPLEIVLKIFSYLGYSDLQAAGSTCQ------------------------------------ 39
            :|.||.|::..|.|:|...||.....||:
Frog   281 FDKLPYELIQFIISHLALPDLCRLAQTCKLMYQHCCDPLQYTHLSLQPYWTNVNDNSLEYLLPRC 345

  Fly    40 ---RW--------HAALDQAEFNQRTRVCFSKVVLSDQLSPGVDLMRCERRFQHFLFEDVTLGQV 93
               :|        ...:..:.|::..:||            |.:|:|.|....||| .:..|..:
Frog   346 SLVQWLNLSWTGNRGLISTSGFSRLLKVC------------GSELVRLELACGHFL-NEACLEVI 397

  Fly    94 KELMRFMGRTAQSLALDNVDLNDKQFYGMLGVLPHLHSLSLKRC--LPLFMSGSFLDSYNNSCPD 156
            .|:                             .|:|..|:|..|  ||       ..::::.|
Frog   398 AEM-----------------------------CPNLQELNLSSCDKLP-------PQAFSHIC-- 424

  Fly   157 LNDLASNLAGIKELTLCENQYLTDAILMRLTSFMPSLEAINMSGCHIAFHNAIHRRFYPATSSSD 221
                  .|:|:|.|.|...: :....|:.:.:|.|.::.:|:..|.:
Frog   425 ------KLSGLKRLVLYRTK-IEQTALLSILNFCPEIQHLNLGSCVL------------------ 464

  Fly   222 HVLPSESVLTFKFILTILNLQRRTLRVLNF--SHTLIGQALLALCDLNLQLQRLYLAGCRQLNCT 284
                   :..:..:.::|..:.:.||.|:.  ...:..:.:..|....|.|:.|.|..|..|..:
Frog   465 -------IEDYDLVASVLGAKCKKLRSLDLWRCKNITERGIAELASGCLLLEELDLGWCPTLQSS 522

  Fly   285 T--ILNFLATQPQLCALDLSATMCVNDENLAALVQTNPQLEHLKVNGCLSITNAGAIHLAKLKCL 347
            |  .:|..:..|.|..|.|:|...|.|.::..|.:....|:.|.:.|...::.|....|  |:|.
Frog   523 TGCFVNLASKLPNLRKLFLTANRSVCDSDIEELARNCQHLQQLDILGTRMVSPAALCKL--LECC 585

  Fly   348 KS---LDISNCDNLTSSGIIEGIASEENPVIQEL 378
            |.   ||:|.|..:.|.            |:|||
Frog   586 KELFLLDVSFCSQIDSR------------VVQEL 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	32/115 (28%)
		leucine-rich repeat	270..295	CDD:275381	7/26 (27%)
		leucine-rich repeat	296..319	CDD:275381	7/22 (32%)
		leucine-rich repeat	322..346	CDD:275381	6/23 (26%)
		leucine-rich repeat	347..399	CDD:275381	10/35 (29%)
		leucine-rich repeat	400..426	CDD:275381
		leucine-rich repeat	427..535	CDD:275381
		AMN1	515..>642	CDD:187754
		leucine-rich repeat	536..560	CDD:275381
		leucine-rich repeat	561..586	CDD:275381
		leucine-rich repeat	587..612	CDD:275381
		leucine-rich repeat	613..638	CDD:275381
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689	12/78 (15%)
		leucine-rich repeat	129..166	CDD:275381	8/38 (21%)
		leucine-rich repeat	167..192	CDD:275381	5/24 (21%)
		leucine-rich repeat	193..244	CDD:275381	3/50 (6%)
		C2	<231..274	CDD:301316	7/44 (16%)
		leucine-rich repeat	246..269	CDD:275381	4/24 (17%)
fbxl4	XP_031761765.1	F-box-like	281..325	CDD:403981	11/43 (26%)
		leucine-rich repeat	296..318	CDD:275381	5/21 (24%)
		leucine-rich repeat	319..341	CDD:275381	0/21 (0%)
		leucine-rich repeat	348..377	CDD:275381	5/40 (13%)
		leucine-rich repeat	378..403	CDD:275381	8/54 (15%)
		leucine-rich repeat	404..428	CDD:275381	8/38 (21%)
		AMN1	427..606	CDD:187754	44/218 (20%)
		leucine-rich repeat	429..453	CDD:275381	5/24 (21%)
		leucine-rich repeat	454..481	CDD:275381	3/51 (6%)
		leucine-rich repeat	482..507	CDD:275381	4/24 (17%)
		leucine-rich repeat	508..535	CDD:275381	7/26 (27%)
		leucine-rich repeat	536..561	CDD:275381	7/24 (29%)
		leucine-rich repeat	562..587	CDD:275381	7/26 (27%)
		leucine-rich repeat	588..613	CDD:275381	9/32 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910