DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8272 and Fbxl13

DIOPT Version :9

Sequence 1:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_038962809.1	Gene:	Fbxl13 / 100125363	RGDID:	1642425	Length:	823	Species:	Rattus norvegicus

Alignment Length:	713	Identity:	144/713 - (20%)
Similarity:	246/713 - (34%)	Gaps:	245/713 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LPLEIVLKIFSYLGYSDLQAAGSTCQRWHAALDQAEFNQRTRVCFSKVVLSDQLSPGVDLMRCER 78
            ||.:.|::||.||.:.||.:.....:.|.:.:.:..
  Rat   245 LPDQAVVQIFVYLTFKDLVSCSQVNRSWMSMIQRGS----------------------------- 280

  Fly    79 RFQHFLFEDVTLGQVKELM-RFMGRTAQSLALDNVDLNDKQFYGMLGVLPHLHSLSLKRCLPLFM 142
                 |:..:....||.:. |.:..|.|...|:.:.||   |.|.:     |.:.:||.
  Rat   281 -----LWNSIDFSTVKNIADRCVVTTLQKWRLNVLRLN---FRGCV-----LRAKTLKS------ 326

  Fly   143 SGSFLDSYNNSCPDLNDLASNLAGIKELTLCENQYLTDAILMRLTSFMPSLEAINMSGCHIAFHN 207
                              .|:...::||.:.:....||..:..::...|.:..:|:|.
  Rat   327 ------------------VSHCKNLQELNVSDCPSFTDESMRHISEGCPGVLYLNLSN------- 366

  Fly   208 AIHRRFYPATSSSDHVLPSESVLTFKFILTILNLQRRTLRVL-NFSHTLIGQALLALCDLNLQLQ 271
                                        .||.|   ||:|:| .:.|               .||
  Rat   367 ----------------------------TTITN---RTMRLLPRYFH---------------NLQ 385

  Fly   272 RLYLAGCRQLNCTTI--LNFLATQPQLCALDLSATMCVNDENLAALVQTNPQLEHLKVNGCLSIT 334
            .|.||.||:.....:  ||......:|..||||....::.:....:..:...:.||.:|...::|
  Rat   386 NLSLAYCRKFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRNIANSCTGIMHLTINDMPTLT 450

  Fly   335 NAGAIHLAKLKCLKSLDISNCDNLTSSGIIEGIASEENPVIQELNVSYLQIC------------- 386
            :         .|:|.| :..|..::|...|      .:|.|.:.....|..|
  Rat   451 D---------NCVKVL-VEKCPRISSVVFI------GSPHISDCAFKALSACDLKKIRFEGNKRI 499

  Fly   387 -EECIKAIASNLRCLRSLHLNHCVNGATDEAIQSVIGQLRWLRELSLEHCSGLTDAALTGINISK 450
             :.|.|::..|...:..:::..| .|.||.:::| :..|:.|..|:|.:|..:.|..|...
  Rat   500 TDACFKSVDRNYPGISHIYMVDC-KGLTDSSLKS-LSVLKQLTVLNLTNCVRIGDIGLRQF---- 558

  Fly   451 LEMSRKQSGSQVSSMDNFYPPYSNTLAERD----SLAGSLQSIKISLRSKAEDEIVRDARRKQAM 511
                             |..|.|..|.|.:    ||.|....|::|
  Rat   559 -----------------FDGPASVKLRELNLANCSLLGDTSVIRLS------------------- 587

  Fly   512 LAAYEMNLIREDDFEGHNIQQLRGLRSLNLRGCNKISDVSLKY--------------------GL 556
                               ::...|..||||.|..::|::::|                    ||
  Rat   588 -------------------ERCPNLHYLNLRNCEHLTDLAIEYIASMLSLISIDLSGTLISNEGL 633

  Fly   557 ----KHIELRRLMLSNCQQISLLGMEAMASSCPSIEELDLSDCYNITDKTIQVVTSKLPRLKALH 617
                :|.:||.:.||.|..|:..|:.|...:..::|.||:|.|..:||..|:.:.....|:.:||
  Rat   634 AILSRHRKLREVSLSECVNITDFGIRAFCKTSLALEHLDVSYCAQLTDDIIKTIAIFCTRITSLH 698

  Fly   618 ISGCSQLTEHTLDAIITNCSCLQTLSIYRCRSMYTD--LEERLSGVKTLRNLNMDNLTSIDNA 678
            |:||.::|:..::.:...|..|..|.|..|..: ||  |::...|.|.||.|.|....||.:|
  Rat   699 IAGCPKITDGGMEILSARCHYLHILDISGCVQL-TDQILQDLQIGCKQLRILKMQFCKSISSA 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	41/186 (22%)
		leucine-rich repeat	270..295	CDD:275381	9/26 (35%)
		leucine-rich repeat	296..319	CDD:275381	5/22 (23%)
		leucine-rich repeat	322..346	CDD:275381	4/23 (17%)
		leucine-rich repeat	347..399	CDD:275381	12/65 (18%)
		leucine-rich repeat	400..426	CDD:275381	6/25 (24%)
		leucine-rich repeat	427..535	CDD:275381	16/111 (14%)
		AMN1	515..>642	CDD:187754	36/150 (24%)
		leucine-rich repeat	536..560	CDD:275381	11/47 (23%)
		leucine-rich repeat	561..586	CDD:275381	8/24 (33%)
		leucine-rich repeat	587..612	CDD:275381	8/24 (33%)
		leucine-rich repeat	613..638	CDD:275381	7/24 (29%)
		leucine-rich repeat	639..663	CDD:275381	8/25 (32%)
		F-box-like	12..>44	CDD:289689	10/29 (34%)
		leucine-rich repeat	129..166	CDD:275381	4/36 (11%)
		leucine-rich repeat	167..192	CDD:275381	4/24 (17%)
		leucine-rich repeat	193..244	CDD:275381	5/50 (10%)
		C2	<231..274	CDD:301316	10/43 (23%)
		leucine-rich repeat	246..269	CDD:275381	3/23 (13%)
Fbxl13	XP_038962809.1	Sfi1	<134..>214	CDD:400658
		F-box-like	242..286	CDD:403981	11/74 (15%)
		leucine-rich repeat	257..270	CDD:275381	3/12 (25%)
		leucine-rich repeat	282..308	CDD:275381	5/25 (20%)
		AMN1	308..477	CDD:187754	49/269 (18%)
		leucine-rich repeat	309..332	CDD:275381	8/54 (15%)
		leucine-rich repeat	333..358	CDD:275381	4/24 (17%)
		leucine-rich repeat	359..383	CDD:275381	10/76 (13%)
		leucine-rich repeat	384..402	CDD:275381	7/17 (41%)
		leucine-rich repeat	412..437	CDD:275381	5/24 (21%)
		leucine-rich repeat	438..463	CDD:275381	8/34 (24%)
		leucine-rich repeat	464..486	CDD:275381	5/27 (19%)
		leucine-rich repeat	488..513	CDD:275381	3/24 (13%)
		leucine-rich repeat	514..534	CDD:275381	5/21 (24%)
		AMN1	525..733	CDD:187754	59/268 (22%)
		leucine-rich repeat	539..563	CDD:275381	7/44 (16%)
		leucine-rich repeat	567..592	CDD:275381	7/62 (11%)
		leucine-rich repeat	593..617	CDD:275381	8/23 (35%)
		leucine-rich repeat	618..641	CDD:275381	3/22 (14%)
		leucine-rich repeat	642..667	CDD:275381	8/24 (33%)
		leucine-rich repeat	668..693	CDD:275381	8/24 (33%)
		leucine-rich repeat	694..719	CDD:275381	7/24 (29%)
		leucine-rich repeat	720..745	CDD:275381	8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346627
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830