DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gcl and GMCL1

DIOPT Version :9

Sequence 1:	NP_724708.1	Gene:	gcl / 35864	FlyBaseID:	FBgn0005695	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_848526.1	Gene:	GMCL1 / 64395	HGNCID:	23843	Length:	515	Species:	Homo sapiens

Alignment Length:	491	Identity:	174/491 - (35%)
Similarity:	274/491 - (55%)	Gaps:	43/491 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KRKRST--------DSSLGKD----DPAQLDTTQPKKKKLLTTTQYIYKALFKEEKNSDVAVMAL 73
            |||||:        ||...:|    |..|.....|::|||.:|::|||:.||...:|||:.:.||
Human    51 KRKRSSGSFCYCHPDSETDEDEEEGDEQQRLLNTPRRKKLKSTSKYIYQTLFLNGENSDIKICAL 115

  Fly    74 DKVWHLHKVYLSQSPYFYTMFNGTWREAQQNFIQITILDDRITVASLDAVFGSMYSDEIEIESAD 138
            .:.|.|||:||.||.||.:||:|:|:|:..|.|::.|.|..|.|.:|...|||:|.|::.|:.:.
Human   116 GEEWSLHKIYLCQSGYFSSMFSGSWKESSMNIIELEIPDQNIDVEALQVAFGSLYRDDVLIKPSR 180

  Fly   139 VISVLATATLFHLDGIIDKCAEVMVDNISPETAIQYYEAACQYGVVGVKKSTFQWFQINLLSIYS 203
            |:::||.|.|..|||:|.:|.|.|.:.::.:|...||.:|..||:..|||...:|...||::  .
Human   181 VVAILAAACLLQLDGLIQQCGETMKETVNVKTVCGYYTSAGTYGLDSVKKKCLEWLLNNLMT--H 243

  Fly   204 KQPNLLRHISIELMSALTASPDLYVMQTEFSLYTLLRTWMFLRLHPDYDPEDPVQRAEALKTQEL 268
            :...|.:.:||.:|..|..|.:|:|||.|..:||.|:.||||:|.|.::        .:||  :|
Human   244 QNVELFKELSINVMKQLIGSSNLFVMQVEMDIYTALKKWMFLQLVPSWN--------GSLK--QL 298

  Fly   269 LVNAGVETHAPSGDVVQWTYFTSRS---EERSFLATPEGQPYVKVFQKLRTQYLTNHYMDLKIIY 330
            |....|             :|:.:.   |..:||.|.:|:|:|.||:.||.||:.:.....:||.
Human   299 LTETDV-------------WFSKQRKDFEGMAFLETEQGKPFVSVFRHLRLQYIISDLASARIIE 350

  Fly   331 NDNIIPKEWLYRHIHNHWDALLRIDHGQEDCSPQQLDDEQFFENCMRCGRMLLEPGYQKWRWTGF 395
            .|.::|.|||.......|.|:||.:...| ..||:::.|:...|.|||||.|.:.|...||||||
Human   351 QDAVVPSEWLSSVYKQQWFAMLRAEQDSE-VGPQEINKEELEGNSMRCGRKLAKDGEYCWRWTGF 414

  Fly   396 NFGMDLILIMDSRRLNIRRHHRHEH-ERVLSLQTKRKFMVRTTVTSINAQRQAVFTQTSEICSLS 459
            |||.||::...:|.:..:|:..::. ...:|||.:|....|..:.|.::..:.:.::|:....|:
Human   415 NFGFDLLVTYTNRYIIFKRNTLNQPCSGSVSLQPRRSIAFRLRLASFDSSGKLICSRTTGYQILT 479

  Fly   460 LEKNEEVPLMVLDPK-LVHPLLISINMLVVMPPNQS 494
            |||::|..:|.||.: |:.||.|..|.|.:.|..::
Human   480 LEKDQEQVVMNLDSRLLIFPLYICCNFLYISPEKKN 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcl	NP_724708.1	BTB	56..163	CDD:279045	47/106 (44%)
gcl	NP_724708.1	BTB	67..166	CDD:197585	43/98 (44%)
GMCL1	NP_848526.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		Nuclear localization signal. /evidence=ECO:0000255	49..55		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..85		5/19 (26%)
		Nuclear localization signal. /evidence=ECO:0000255	85..91		3/5 (60%)
		BTB	98..207	CDD:306997	48/108 (44%)
		BACK	213..>283	CDD:197943	25/71 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142981
Domainoid	1	1.000	165	1.000	Domainoid score	I3919
eggNOG	1	0.900	-	-		E1_KOG4682
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8021
Inparanoid	1	1.050	302	1.000	Inparanoid score	I2680
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48664
OrthoDB	1	1.010	-	-		D1111791at2759
OrthoFinder	1	1.000	-	-		FOG0000347
OrthoInspector	1	1.000	-	-		otm41524
orthoMCL	1	0.900	-	-		OOG6_106864
Panther	1	1.100	-	-	LDO	PTHR23231
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4362
SonicParanoid	1	1.000	-	-		X249
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800