DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gcl and gmcl1

DIOPT Version :9

Sequence 1:	NP_724708.1	Gene:	gcl / 35864	FlyBaseID:	FBgn0005695	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_996933.1	Gene:	gmcl1 / 322146	ZFINID:	ZDB-GENE-030131-865	Length:	503	Species:	Danio rerio

Alignment Length:	500	Identity:	176/500 - (35%)
Similarity:	284/500 - (56%)	Gaps:	43/500 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QIVGSMHMNVAEVFSNRRKRKRS----TDSSLGKDDPAQLDTTQPKKKKLLTTTQYIYKALFKEE 63
            |..|:.|.      ...||||||    .||...::| :||||  |::|||.:|::|||:.||...
Zfish    22 QCAGNRHS------CECRKRKRSLRCECDSEPEEED-SQLDT--PRRKKLKSTSKYIYQTLFLNG 77

  Fly    64 KNSDVAVMALDKVWHLHKVYLSQSPYFYTMFNGTWREAQQNFIQITILDDRITVASLDAVFGSMY 128
            :|||:.:.||.:.|:|||:||.||.||.:||:|:|:|:....|::.|.|..|...:|..||||:|
Zfish    78 ENSDIQIRALGQEWNLHKIYLCQSGYFSSMFSGSWKESNMMVIELEIPDQNIDTEALQVVFGSLY 142

  Fly   129 SDEIEIESADVISVLATATLFHLDGIIDKCAEVMVDNISPETAIQYYEAACQYGVVGVKKSTFQW 193
            .|::.|:.:.|:::||.|.:..|||:|.:|.|.|.:|::.:|...||.:|..||:..|.|...:|
Zfish   143 RDDVLIKPSRVVNILAAACMLQLDGLIQQCGETMKENVNVKTVCSYYNSATMYGLDSVMKKCLEW 207

  Fly   194 FQINLLSIYSKQPNLLRHISIELMSALTASPDLYVMQTEFSLYTLLRTWMFLRLHPDYDPEDPVQ 258
            ...||::  .:...|::.:..::|..|..|.||:|||.|..:||.|:.||||:|:|.:|  .|:
Zfish   208 LLNNLMT--HQNVELMKELGGDIMEQLIQSSDLFVMQVEMDVYTALKKWMFLQLNPSWD--GPI- 267

  Fly   259 RAEALKTQELLVNAGV---ETHAPSGDVVQWTYFTSRSEERSFLATPEGQPYVKVFQKLRTQYLT 320
                   ::||::|..   :..:.:|:|            ..||.|.:|.|:|.||:.:|.||:.
Zfish   268 -------KQLLLDADAWLCKRRSDAGEV------------EPFLNTDDGMPFVPVFRHIRLQYII 313

  Fly   321 NHYMDLKIIYNDNIIPKEWLYRHIHNHWDALLRIDHGQEDCSPQQLDDEQFFENCMRCGRMLLEP 385
            |.....:::..|||:|.|||.......|.|:||.:| ..|..||:.:.|:|..|.|||||.|.:.
Zfish   314 NDLASARMLERDNILPPEWLSSVYKQQWFAMLRTEH-DNDNGPQEANKEEFELNSMRCGRKLTKD 377

  Fly   386 GYQKWRWTGFNFGMDLILIMDSRRLNIRRHHRHEH-ERVLSLQTKRKFMVRTTVTSINAQRQAVF 449
            |...|||||||:|.||::...:|.:..:|:...:. ...:|||.:|....|..:.|.::..:.|.
Zfish   378 GDYCWRWTGFNYGFDLLVTYTNRFIIFKRNTLSQPCGGAVSLQPRRHLAYRLRLASFDSSGKVVC 442

  Fly   450 TQTSEICSLSLEKNEEVPLMVLDPKLV-HPLLISINMLVVMPPNQ 493
            ::::....::|||::|..:|.||.:|: .||.:..|.|...|.::
Zfish   443 SRSTGYQLVTLEKDQEYVVMNLDSRLLSFPLYVCCNFLYTSPSSE 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcl	NP_724708.1	BTB	56..163	CDD:279045	45/106 (42%)
gcl	NP_724708.1	BTB	67..166	CDD:197585	41/98 (42%)
gmcl1	NP_996933.1	BTB	70..177	CDD:279045	45/106 (42%)
		BTB	81..179	CDD:197585	41/97 (42%)
		BACK	185..>255	CDD:197943	23/71 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575832
Domainoid	1	1.000	179	1.000	Domainoid score	I3495
eggNOG	1	0.900	-	-		E1_KOG4682
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8021
Inparanoid	1	1.050	308	1.000	Inparanoid score	I2609
OMA	1	1.010	-	-		QHG48664
OrthoDB	1	1.010	-	-		D1111791at2759
OrthoFinder	1	1.000	-	-		FOG0000347
OrthoInspector	1	1.000	-	-		oto41658
orthoMCL	1	0.900	-	-		OOG6_106864
Panther	1	1.100	-	-	LDO	PTHR23231
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4362
SonicParanoid	1	1.000	-	-		X249
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800