DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment gcl and KLHL10

DIOPT Version :9

Sequence 1:NP_724708.1 Gene:gcl / 35864 FlyBaseID:FBgn0005695 Length:569 Species:Drosophila melanogaster
Sequence 2:NP_001316524.1 Gene:KLHL10 / 317719 HGNCID:18829 Length:608 Species:Homo sapiens


Alignment Length:235 Identity:47/235 - (20%)
Similarity:93/235 - (39%) Gaps:16/235 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 QP-KKKKLLTTTQYIYKALFKEEKNSDVAVMALDKVWHLHK-VYLSQSPYFYTMFNGTWREAQQN 104
            || .::|:......|:..|..|.|..||.:......:..|| :..|.|.||..:|...|...::.
Human    14 QPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKK 78

  Fly   105 FIQITILDDRITVASLDAVFGSMYSDEIEIESADVISVLATATLFHLDGIIDKCAEVMVDNISPE 169
            ...|    ..|:...:..:....|:..:.|...:|..:||.|..|::.||:..|.|.:...:..:
Human    79 VYNI----PGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLD 139

  Fly   170 TAIQYYEAACQYGVVGVKKSTFQWFQINLLSIYSKQPNLLRHISIELMSALTASPDLYVMQTEFS 234
            ..|...:....|....:::..:.:...|...:.......| .:|:..:..:....:|.|.| |.:
Human   140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFL-ELSVTELKDIIEKDELNVKQ-EDA 202

  Fly   235 LYTLLRTWMFLRLHPDYDPEDPVQRAEAL--KTQELLVNA 272
            ::..:..|:      .:||::..|....|  |.:..|::|
Human   203 VFEAILKWI------SHDPQNRKQHISILLPKVRLALMHA 236

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gclNP_724708.1 BTB 56..163 CDD:279045 26/107 (24%)
BTB 67..166 CDD:197585 23/99 (23%)
KLHL10NP_001316524.1 BTB 29..133 CDD:279045 26/107 (24%)
PHA03098 36..572 CDD:222983 41/213 (19%)
BACK 141..242 CDD:197943 17/104 (16%)
Kelch 1 292..339
Kelch 293..339 CDD:128874
KELCH repeat 329..372 CDD:276965
Kelch 2 340..386
Kelch 341..386 CDD:128874
Kelch_1 375..419 CDD:279660
KELCH repeat 376..420 CDD:276965
Kelch 3 388..433
KELCH repeat 423..466 CDD:276965
Kelch 434..480 CDD:128874
Kelch 4 434..480
KELCH repeat 470..513 CDD:276965
Kelch 481..527 CDD:128874
Kelch 5 481..527
KELCH repeat 517..561 CDD:276965
Kelch 528..574 CDD:128874
Kelch 6 529..574
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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