DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gcl and Gmcl1

DIOPT Version :9

Sequence 1:	NP_724708.1	Gene:	gcl / 35864	FlyBaseID:	FBgn0005695	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001029103.1	Gene:	Gmcl1 / 312516	RGDID:	1359265	Length:	524	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	173/490 - (35%)
Similarity:	271/490 - (55%)	Gaps:	39/490 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RKRKRS------------TDSSLGKDDPAQLDTTQPKKKKLLTTTQYIYKALFKEEKNSDVAVMA 72
            ||||||            ||....:.|..|.....|::|||.:|::|||:.||...:|||:.:.|
  Rat    48 RKRKRSSGTFCYCHPESETDEDEDEGDEQQRLLNTPRRKKLKSTSKYIYQTLFLNGENSDIKICA 112

  Fly    73 LDKVWHLHKVYLSQSPYFYTMFNGTWREAQQNFIQITILDDRITVASLDAVFGSMYSDEIEIESA 137
            |.:.|.|||:||.||.||.:||:|:|:|:..|.|::.|.|..|.:.:|...|||:|.|::.|:.:
  Rat   113 LGEEWSLHKIYLCQSGYFSSMFSGSWKESSMNIIELEIPDQNIDIEALQVAFGSLYRDDVLIKPS 177

  Fly   138 DVISVLATATLFHLDGIIDKCAEVMVDNISPETAIQYYEAACQYGVVGVKKSTFQWFQINLLSIY 202
            .|:::||.|.:..|||:|.:|.|.|.:.||..|...||.:|..||:..|||...:|...||::..
  Rat   178 RVVAILAAACMLQLDGLIQQCGETMKETISVRTVCGYYTSAGTYGLDSVKKKCLEWLLNNLMTHQ 242

  Fly   203 SKQPNLLRHISIELMSALTASPDLYVMQTEFSLYTLLRTWMFLRLHPDYDPEDPVQRAEALKTQE 267
            |.:  |.:.:||.:|..|..|.:|:|||.|..:||.|:.||||:|.|.::        .:||  :
  Rat   243 SVE--LFKELSINVMRQLIGSSNLFVMQVEMDVYTALKKWMFLQLVPSWN--------GSLK--Q 295

  Fly   268 LLVNAGVETHAPSGDVVQW-TYFTSRSEERSFLATPEGQPYVKVFQKLRTQYLTNHYMDLKIIYN 331
            ||....|           | :.:....|..:||.|.:|:|:..||:.||.||:.:.....:||..
  Rat   296 LLTETDV-----------WFSKWKKDFEGTTFLETEQGKPFAPVFRHLRLQYIISDLASARIIEQ 349

  Fly   332 DNIIPKEWLYRHIHNHWDALLRIDHGQEDCSPQQLDDEQFFENCMRCGRMLLEPGYQKWRWTGFN 396
            |:::|.|||.......|.|:||.:...| ..||:::.|:...|.|||||.|.:.|...|||||||
  Rat   350 DSLVPSEWLASVYKQQWLAMLRAEQDSE-VGPQEINKEELEGNSMRCGRKLAKDGEYCWRWTGFN 413

  Fly   397 FGMDLILIMDSRRLNIRRHHRHEH-ERVLSLQTKRKFMVRTTVTSINAQRQAVFTQTSEICSLSL 460
            ||.||::...:|.:..:|:..::. ...:|||.:|....|..:.|.::..:.:.::.:....|:|
  Rat   414 FGFDLLVTYTNRYIIFKRNTLNQPCSGSVSLQPRRSIAFRLRLASFDSSGKLICSRATGYQILTL 478

  Fly   461 EKNEEVPLMVLDPK-LVHPLLISINMLVVMPPNQS 494
            ||::|..:|.||.: |:.||.|..|.|.:.|..::
  Rat   479 EKDQEQVVMNLDSRLLIFPLYICCNFLYISPEKRT 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcl	NP_724708.1	BTB	56..163	CDD:279045	45/106 (42%)
gcl	NP_724708.1	BTB	67..166	CDD:197585	41/98 (42%)
Gmcl1	NP_001029103.1	BTB_POZ_GCL	91..205	CDD:349614	49/113 (43%)
Gmcl1	NP_001029103.1	BACK_GCL	206..283	CDD:350570	31/78 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4713
eggNOG	1	0.900	-	-		E1_KOG4682
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8021
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2748
OMA	1	1.010	-	-		QHG48664
OrthoDB	1	1.010	-	-		D1111791at2759
OrthoFinder	1	1.000	-	-		FOG0000347
OrthoInspector	1	1.000	-	-		otm45646
orthoMCL	1	0.900	-	-		OOG6_106864
Panther	1	1.100	-	-	LDO	PTHR23231
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X249
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840