DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gcl and LOC302576

DIOPT Version :9

Sequence 1:	NP_724708.1	Gene:	gcl / 35864	FlyBaseID:	FBgn0005695	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001013981.1	Gene:	LOC302576 / 302576	RGDID:	1549693	Length:	498	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	151/495 - (30%)
Similarity:	237/495 - (47%)	Gaps:	50/495 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SNRRKRKRSTDSSLGKDDPAQLDTTQPK--------------KKKLLTTTQYIYKALFKEEKNSD 67
            |..||||.|...:||...    |...|:              :|::..::.|.|:.||....:||
  Rat    31 SGSRKRKLSNSVNLGPSP----DIHGPQNQRINLNQVLNYIYRKRVKISSNYAYENLFLNGNDSD 91

  Fly    68 VAVMALDKVWHLHKVYLSQSPYFYTMFNGTWREAQQNFIQITILDDRITVASLDAVFGSMYSDE- 131
            :.:.||.:.|.||||:|..|.||..:....|:|::...|::.|.::.|...||..||||:|:||
  Rat    92 IKICALGRTWCLHKVFLCHSGYFANILKDIWKESRNGVIRLLIRNEDIDTRSLHFVFGSLYTDEN 156

  Fly   132 IEIESADVISVLATATLFHLDGIIDKCAEVMVDNISPETAIQYYEAACQYGVVGVKKSTFQWFQI 196
            :.:...:|..|||.|.|..:|.:|.:|.::|...|:..||..||.||..|.:..||...|||...
  Rat   157 LSLTPLEVPRVLAAACLLRVDRVIRQCEKIMKTTINRNTACSYYLAAETYRLKAVKTECFQWLLY 221

  Fly   197 NLLSIYSKQPN--LLRHISIELMSALTASPDLYVMQTEFSLYTLLRTWMFLRLHPDYDPEDPVQR 259
            ||:    ..|:  |.:.:.::||..||:|..|.|||.|..:|..|:|||||.|:|.::.
  Rat   222 NLM----VHPSVALYKAVDLKLMYLLTSSSHLLVMQKEIDVYITLKTWMFLYLNPCWNG------ 276

  Fly   260 AEALKTQELLVNAGVETHAPSGDVVQWTY-FTSRSEERSFLATPEGQPYVKVFQKLRTQYLTNHY 323
                ..:|||.:..           .|.| :....:..|||.:.||..:..||:|||.|::....
  Rat   277 ----TMKELLDHTN-----------NWLYTYMGYVDNISFLESEEGLIFQPVFKKLRFQHIICDL 326

  Fly   324 MDLKIIYNDNIIPKEWLYRHIHNHWDALLRIDHGQEDCSPQQLDDEQFFENCMRCGRMLLEPGYQ 388
            ....::..|.:||.|||......||...|:... |:...||.:::|:..:|.||||:|:...|..
  Rat   327 ASTSVLERDRLIPAEWLSPIYKQHWLTYLQAQE-QKAIGPQTINEEELEQNTMRCGKMIPTDGKY 390

  Fly   389 KWRWTGFNFGMDLILIMDSRRLNIRRHHRHEHERVLSLQTKRKFMVRTTVTSINAQRQAVFTQTS 453
            .|:|........|.:|..|..: |.:....:.:....|...|.|:.:.|:...::..:..|::|:
  Rat   391 IWKWLACKLSFPLCVIFTSHYI-IFKQCFQQCDGSACLNHVRNFVFKITLVCFDSNEKVTFSKTT 454

  Fly   454 EICSLSLEKNEEVPLMVLDPK-LVHPLLISINMLVVMPPN 492
            ...:|:.|.|||..:|.||.: |..||.|..|.|.:...|
  Rat   455 GYKTLTFENNEEQIVMKLDAEALTFPLYIFANFLFLKLEN 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcl	NP_724708.1	BTB	56..163	CDD:279045	39/107 (36%)
gcl	NP_724708.1	BTB	67..166	CDD:197585	36/99 (36%)
LOC302576	NP_001013981.1	BTB_POZ	76..190	CDD:365784	41/113 (36%)
LOC302576	NP_001013981.1	BACK	191..268	CDD:421692	32/80 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336684
Domainoid	1	1.000	138	1.000	Domainoid score	I4713
eggNOG	1	0.900	-	-		E1_KOG4682
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2748
OMA	1	1.010	-	-		QHG48664
OrthoDB	1	1.010	-	-		D1111791at2759
OrthoFinder	1	1.000	-	-		FOG0000347
OrthoInspector	1	1.000	-	-		otm45646
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23231
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X249
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.870