DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gcl and Gmcl1

DIOPT Version :9

Sequence 1:	NP_724708.1	Gene:	gcl / 35864	FlyBaseID:	FBgn0005695	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_035948.3	Gene:	Gmcl1 / 23885	MGIID:	1345156	Length:	524	Species:	Mus musculus

Alignment Length:	490	Identity:	173/490 - (35%)
Similarity:	271/490 - (55%)	Gaps:	39/490 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RKRKRS------------TDSSLGKDDPAQLDTTQPKKKKLLTTTQYIYKALFKEEKNSDVAVMA 72
            ||||||            ||....:.|..|.....|::|||.:|::|||:.||...:|||:.:.|
Mouse    48 RKRKRSSGTFCYCHPDSETDDDEDEGDEQQRLLNTPRRKKLKSTSKYIYQTLFLNGENSDIKICA 112

  Fly    73 LDKVWHLHKVYLSQSPYFYTMFNGTWREAQQNFIQITILDDRITVASLDAVFGSMYSDEIEIESA 137
            |.:.|.|||:||.||.||.:||:|:|:|:..|.|::.|.|..|.:.:|...|||:|.|::.|:.:
Mouse   113 LGEEWSLHKIYLCQSGYFSSMFSGSWKESSMNIIELEIPDQNIDIEALQVAFGSLYRDDVLIKPS 177

  Fly   138 DVISVLATATLFHLDGIIDKCAEVMVDNISPETAIQYYEAACQYGVVGVKKSTFQWFQINLLSIY 202
            .|:::||.|.:..|||:|.:|.|.|.:.||..|...||.:|..||:..|||...:|...||::..
Mouse   178 RVVAILAAACMLQLDGLIQQCGETMKETISVRTVCGYYTSAGTYGLDSVKKKCLEWLLNNLMTHQ 242

  Fly   203 SKQPNLLRHISIELMSALTASPDLYVMQTEFSLYTLLRTWMFLRLHPDYDPEDPVQRAEALKTQE 267
            |.:  |.:.:||.:|..|..|.:|:|||.|..:||.|:.||||:|.|.::        .:||  :
Mouse   243 SVE--LFKELSINVMKQLIGSSNLFVMQVEMDVYTALKKWMFLQLVPSWN--------GSLK--Q 295

  Fly   268 LLVNAGVETHAPSGDVVQW-TYFTSRSEERSFLATPEGQPYVKVFQKLRTQYLTNHYMDLKIIYN 331
            ||....|           | :.:....|..:||.|.:|:|:..||:.||.||:.:.....:||..
Mouse   296 LLTETDV-----------WFSKWKKDFEGTTFLETEQGKPFAPVFRHLRLQYIISDLASARIIEQ 349

  Fly   332 DNIIPKEWLYRHIHNHWDALLRIDHGQEDCSPQQLDDEQFFENCMRCGRMLLEPGYQKWRWTGFN 396
            |:::|.|||.......|.|:||.:...| ..||:::.|:...|.|||||.|.:.|...|||||||
Mouse   350 DSLVPSEWLAAVYKQQWLAMLRAEQDSE-VGPQEINKEELEGNSMRCGRKLAKDGEYCWRWTGFN 413

  Fly   397 FGMDLILIMDSRRLNIRRHHRHEH-ERVLSLQTKRKFMVRTTVTSINAQRQAVFTQTSEICSLSL 460
            ||.||::...:|.:..:|:..::. ...:|||.:|....|..:.|.::..:.:.::.:....|:|
Mouse   414 FGFDLLVTYTNRYIIFKRNTLNQPCSGSVSLQPRRSIAFRLRLASFDSSGKLICSRATGYQILTL 478

  Fly   461 EKNEEVPLMVLDPK-LVHPLLISINMLVVMPPNQS 494
            ||::|..:|.||.: |:.||.|..|.|.:.|..::
Mouse   479 EKDQEQVVMNLDSRLLIFPLYICCNFLYISPEKRT 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcl	NP_724708.1	BTB	56..163	CDD:279045	45/106 (42%)
gcl	NP_724708.1	BTB	67..166	CDD:197585	41/98 (42%)
Gmcl1	NP_035948.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Nuclear localization signal. /evidence=ECO:0000255	47..53		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..83		4/19 (21%)
		Nuclear localization signal. /evidence=ECO:0000255	83..89		3/5 (60%)
		BTB	96..203	CDD:279045	45/106 (42%)
		BTB	107..206	CDD:197585	41/98 (42%)
		BACK	211..>281	CDD:197943	26/71 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833101
Domainoid	1	1.000	119	1.000	Domainoid score	I5768
eggNOG	1	0.900	-	-		E1_KOG4682
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8021
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2661
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48664
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000347
OrthoInspector	1	1.000	-	-		otm43575
orthoMCL	1	0.900	-	-		OOG6_106864
Panther	1	1.100	-	-	LDO	PTHR23231
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4362
SonicParanoid	1	1.000	-	-		X249
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790