DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gcl and BTBD16

DIOPT Version :9

Sequence 1:	NP_724708.1	Gene:	gcl / 35864	FlyBaseID:	FBgn0005695	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001305118.1	Gene:	BTBD16 / 118663	HGNCID:	26340	Length:	507	Species:	Homo sapiens

Alignment Length:	490	Identity:	114/490 - (23%)
Similarity:	193/490 - (39%)	Gaps:	106/490 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VFSNRRKRKRSTDSSLGKDDPAQLDTTQPKKKKLLTTTQ----------------------YIYK 57
            :.||.:.:.|......|..:..:| ..||....||:.:|                      .|.|
Human     2 IMSNTQHKARLERRVTGSTNRWRL-PKQPFSGDLLSLSQMCKALSIDFEEALRNPDRLCISQIQK 65

  Fly    58 ALFKEEKNSDVAVMALDKV-------WHLHKVYLSQSP-----YFYTMFNGT---WRE------- 100
            ..|:..||.|:.....|.:       |.||:..|.||.     |...:..||   .||
Human    66 FFFENFKNKDIQSGEADVILECLGFKWELHQPQLFQSETLAKLYLKALAQGTTHPLRELEELLRA 130

  Fly   101 -----------AQQNFIQITILDDRITVASLDAVFGSMYSDEIEIESADVISVLATATLFHLDGI 154
                       |::..|.:.|.|..:|..:......::|..|:||...|::.|||:|.:....|:
Human   131 QSPKKTKEKSPAKRIIISLKINDPLVTKVAFATALKNLYMSEVEINLEDLLGVLASAHILQFSGL 195

  Fly   155 IDKCAEVMVDNISPETAIQYYEAACQYGVVGVKKSTFQWFQINLLSIYSKQPNLLRHISIELMSA 219
            ..:|.:||:..:.|.|..::|||.|:|....:.....:|.::||:.:...|.: |..|..:|:..
Human   196 FQRCVDVMIARLKPSTIKKFYEAGCKYKEEQLTTGCEKWLEMNLVPLGGTQIH-LHKIPQDLLHK 259

  Fly   220 LTASPDLYVMQTEFSLYTLLRTWMFLRLHPDYDPEDPVQRAEALKTQELLVNAGVETHAPSGDVV 284
            :..||.|:.. :||.|...:..|:||:|:         .:.:|:.|.|.::
Human   260 VLKSPRLFTF-SEFHLLKTMLLWVFLQLN---------YKIQAIPTYETVM-------------- 300

  Fly   285 QWTYFTSRSEERSFLATPEGQPYVKVFQKLRTQYLTNHYMDLKIIYNDNIIPKEWLYRHIHNHWD 349
              |:|.|..|...||....|:....:|..||...:|.. .||:::.:.|..|:.||.:...||:.
Human   301 --TFFKSFPENCCFLDRDIGRSLRPLFLCLRLHGITKG-KDLEVLRHLNFFPESWLDQVTVNHYH 362

  Fly   350 ALLRIDHGQE-----DCSPQQLDDEQFF--ENCMRCGRMLLEPGYQKWR-----WTGFNFGMDLI 402
            ||   ::|.:     |.:.|.:.....|  ||......:.|...:.|.:     .|.::|.|..|
Human   363 AL---ENGGDMVHLKDLNTQAVRFGLLFNQENTTYSKTIALYGFFFKIKGLKHDTTSYSFYMQRI 424

  Fly   403 LIMDSRRLNIRRHHRHEHERVLSLQTKR--KFMVR 435
            ...|....:....|.|     :||:..|  |:.:|
Human   425 KHTDLESPSAVYEHNH-----VSLRAARLVKYEIR 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcl	NP_724708.1	BTB	56..163	CDD:279045	34/139 (24%)
gcl	NP_724708.1	BTB	67..166	CDD:197585	31/131 (24%)
BTBD16	NP_001305118.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142980
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4682
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740