DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gcl and Btbd35f23

DIOPT Version :9

Sequence 1:	NP_724708.1	Gene:	gcl / 35864	FlyBaseID:	FBgn0005695	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001257596.1	Gene:	Btbd35f23 / 100861966	MGIID:	5439401	Length:	498	Species:	Mus musculus

Alignment Length:	509	Identity:	152/509 - (29%)
Similarity:	241/509 - (47%)	Gaps:	66/509 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IVGSMHMNVAEVFSNRRKRKRSTDSSLGKDDPAQLDTTQ---PKK-------KKLLTTTQYIYKA 58
            |.|:.::.|:      |||||::...|...........|   |.:       |::..::...|:.
Mouse    24 IAGASYIPVS------RKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQN 82

  Fly    59 LFKEEKNSDVAVMALDKVWHLHKVYLSQSPYFYTMFNGTWREAQQNFIQITILDDRITVASLDAV 123
            ||.:..:||:.:.||.:.|.||||:|.||.||..:..|||||:....|.:.|.::.|...||..|
Mouse    83 LFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFTNILKGTWRESHHGVINLIIKNEDIDTRSLHFV 147

  Fly   124 FGSMYSD-EIEIESADVISVLATATLFHLDGIIDKCAEVMVDNISPETAIQYYEAACQYGVVGVK 187
            ||::|:| ::.|...:|..|||.|.|..:|.:|.||..:|.:.|:..|...||.||..|.:..||
Mouse   148 FGALYTDADLSITPLEVPQVLAAACLLRVDRVIQKCEGIMKETINRNTVCSYYLAAETYRLKAVK 212

  Fly   188 KSTFQWFQINLLSIYSKQPN--LLRHISIELMSALTASPDLYVMQTEFSLYTLLRTWMFLRLHPD 250
            ...|:|...||:    ..|:  |.:.:.::||..|..|.||.|||.|..:||.|:.||||.|:|.
Mouse   213 TRCFEWLLCNLM----VHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPC 273

  Fly   251 YDPEDPVQRAEALKTQELLVNAG--VETHAPSGDVVQWTYFTSRSEERSFLATPEGQPYVKVFQK 313
            ::.          ..::||.:|.  :.||....|.:            |||.:.||..:..||:|
Mouse   274 WNG----------TMKQLLQHANNWLSTHMAYVDNI------------SFLESEEGLIFQPVFKK 316

  Fly   314 LRTQYLTNHYMDLKIIYNDNIIPKEWLYRHIHNHWDALLRI-DHGQEDCSPQQLDDEQFFENCMR 377
            ||.|::..:.....|:..|.:||..||.......|..|||. ::|.  ..||.:::::..|..||
Mouse   317 LRFQHIICNLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGV--IGPQVINEQELEECTMR 379

  Fly   378 CGRMLLEPGYQKWRWTGFNFGMDLILIMDSRRLNIRRHHR-------HEHERVLSLQTKRKFMVR 435
            ||.|:.:.|...|:|:....|..|.:....:.:.:|:..:       |.|        .|..:.|
Mouse   380 CGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNH--------IRNVIFR 436

  Fly   436 TTVTSINAQRQAVFTQTSEICSLSLEKNEEVPLMVLDPK-LVHPLLISINMLVV 488
            .|:...::.::..|.:|:....|:.|.|:|..:|.||.. |..|:.|..|.|.|
Mouse   437 ITLVCFDSNKRVTFRKTTGYKILTFEYNQEQIVMKLDSDVLTFPMCIFCNFLFV 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcl	NP_724708.1	BTB	56..163	CDD:279045	43/107 (40%)
gcl	NP_724708.1	BTB	67..166	CDD:197585	40/99 (40%)
Btbd35f23	NP_001257596.1	BTB	80..188	CDD:279045	43/107 (40%)
		BTB	91..191	CDD:197585	40/99 (40%)
		BACK	196..>266	CDD:197943	26/73 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833105
Domainoid	1	1.000	119	1.000	Domainoid score	I5768
eggNOG	1	0.900	-	-		E1_KOG4682
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2661
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48664
OrthoDB	1	1.010	-	-		D1111791at2759
OrthoFinder	1	1.000	-	-		FOG0000347
OrthoInspector	1	1.000	-	-		otm43575
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X249
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910