DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gcl and Btbd35f3

DIOPT Version :9

Sequence 1:	NP_724708.1	Gene:	gcl / 35864	FlyBaseID:	FBgn0005695	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001229930.1	Gene:	Btbd35f3 / 100042168	MGIID:	3781882	Length:	496	Species:	Mus musculus

Alignment Length:	500	Identity:	150/500 - (30%)
Similarity:	231/500 - (46%)	Gaps:	62/500 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AEVFSNRRKRKRSTDSSLGKDDPA---QLDTTQPKK-------KKLLTTTQYIYKALFKEEKNSD 67
            |......|||||::...|......   |.....|.:       |::..::...|:.||.:..:||
Mouse    27 ASYIPGSRKRKRNSLEELATSSNVHGPQNQRMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSD 91

  Fly    68 VAVMALDKVWHLHKVYLSQSPYFYTMFNGTWREAQQNFIQITILDDRITVASLDAVFGSMYSD-E 131
            :.:.||.|.|.||||:|.||.||..:..|||||:....|.:.|  ..|...||..|||::|:| :
Mouse    92 IKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLII--KNIDTRSLHFVFGALYTDAD 154

  Fly   132 IEIESADVISVLATATLFHLDGIIDKCAEVMVDNISPETAIQYYEAACQYGVVGVKKSTFQWFQI 196
            :.|...:|..|||.|.|..:|.:|.:|..:|.:.|:..|...||.||..|.:..||...|:|...
Mouse   155 LSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLC 219

  Fly   197 NLLSIYSKQPN--LLRHISIELMSALTASPDLYVMQTEFSLYTLLRTWMFLRLHPDYDPEDPVQR 259
            ||:    ..|:  |.:.:.::||..|..|.||.|||.|..:||.|:.||||.|:|.::.
Mouse   220 NLM----VHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNG------ 274

  Fly   260 AEALKTQELLVNAG--VETHAPSGDVVQWTYFTSRSEERSFLATPEGQPYVKVFQKLRTQYLTNH 322
                ..::||.:|.  :.||....|.:            |||.:.||..:..||:|||.|::...
Mouse   275 ----TMKQLLQHANNWLSTHMAYVDNI------------SFLESEEGLIFQPVFKKLRFQHIICD 323

  Fly   323 YMDLKIIYNDNIIPKEWLYRHIHNHWDALLRI-DHGQEDCSPQQLDDEQFFENCMRCGRMLLEPG 386
            .....|:..|.:||..||.......|..|||. ::|.  ..||.:::::..|..||||.|:.:.|
Mouse   324 LTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGV--IGPQVINEQELEECTMRCGTMIPKDG 386

  Fly   387 YQKWRWTGFNFGMDLILIMDSRRLNIRRHHR-------HEHERVLSLQTKRKFMVRTTVTSINAQ 444
            ...|:|:....|..|.:....:.:.:|:..:       |.|        .|..:.|.|:...::.
Mouse   387 RYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNH--------IRNVIFRITLVCFDSN 443

  Fly   445 RQAVFTQTSEICSLSLEKNEEVPLMVLDPK-LVHPLLISINMLVV 488
            ::..|.:|:....|:.|..||..:|.||.. |..|:.|..|.|.|
Mouse   444 KRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFV 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcl	NP_724708.1	BTB	56..163	CDD:279045	43/107 (40%)
gcl	NP_724708.1	BTB	67..166	CDD:197585	40/99 (40%)
Btbd35f3	NP_001229930.1	BTB	80..186	CDD:279045	43/107 (40%)
		BTB	91..189	CDD:197585	40/99 (40%)
		BACK	194..>264	CDD:197943	26/73 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833123
Domainoid	1	1.000	119	1.000	Domainoid score	I5768
eggNOG	1	0.900	-	-		E1_KOG4682
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2661
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48664
OrthoDB	1	1.010	-	-		D1111791at2759
OrthoFinder	1	1.000	-	-		FOG0000347
OrthoInspector	1	1.000	-	-		otm43575
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X249
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870