Protein Alignment CG14743 and Slc24a3

DIOPT Version :10

• Sequence 1: NP_610408.2
• Gene: CG14743 / 35860
• FlyBaseID: FBgn0033326
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_001343426.1
• Gene: Slc24a3 / 94249
• MGIID: 2137513
• Length: 645
• Species: Mus musculus
• Alignment Length: 626
• Identity: 117/626 - (18%)
• Similarity: 221/626 - (35%)
• Gaps: 200/626 - (31%)

  Fly    67 DNKITEIVVMLLFALIYCFFLCILYEGVNSYFAPTLKIAALKMRINEYMAGVVLVGVANSTPDLL 131
            |.:...:|:.:|.|:...:.|.|:   .:.:|.|:|:....::.::|.:||...:...:|.|:|.
Mouse   103 DRRQGAVVLHVLCAMYMFYALAIV---CDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELF 164

  Fly   132 VNLSPVRME------GLTFNIAMANALTIICLSGGAVCFI---RPFRMNGHSIFRDLLFLLLIIE 187
            .::..|.:.      |.....|:.|   |:|:.|  ||.:   :...::...:.||.::..|.:.
Mouse   165 TSVIGVFITKGDVGVGTIVGSAVFN---ILCIIG--VCGLFAGQVVALSSWCLLRDSIYYTLSVV 224

  Fly   188 LVRFFMNDTALAPWIKGAILLSIYPIYLLI-------------------NIVD------------ 221
            .:..|:.|..:: |.:..:|:.:|.||::|                   |:|:
Mouse   225 ALIVFIYDEKVS-WWESLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSS 288

  Fly   222 -----LILLRYAIRKLRADIEVLRQSPSSREHDLILTEKIVRL---------NNLQQDDEIQILE 272
                 ::||:.|....:|.:.::.:..|:..|.|..:|..:|:         ..|.....:.|.|
Mouse   289 NCDATVVLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINE 353

  Fly   273 -SKLYRKRTY-NAGFFVTPKPLIHH-------------------------KEVDVETNRRILHSK 310
             .:|...|.| |....|..|..|.|                         .|.|.||..   .::
Mouse   354 RQRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDIVAETDNETEN---ENE 415

  Fly   311 ANPKNLFLFSEFLQAINPIDSEGWYL-----SGTCARILQILKAPVTLMLHLVVPLVDYQLVKHG 370
            .|..|   .::..:..:..|.||.|.     ||....:......|::.:|:..||..:    |..
Mouse   416 DNENN---ENDEEEEEDEDDDEGPYTPFDPPSGKLETVKWAFTWPLSFVLYFTVPNCN----KPH 473

  Fly   371 WSKMLNCLQIVLTPFVIFALVETMLVHKYAEWYYVPQFRMAIWSLLVTMPLAIVVFLHSRTDIPP 435
            |.|                            |:.|......:|
Mouse   474 WEK----------------------------WFMVTFASSTLW---------------------- 488

  Fly   436 FYHSSYCALTISTVIIFFWICAWEMDALISIIGVVFDLAPSYMSITFNSVSAATADLIAYAHLAK 500
                         :..|.::..|    :::|||....:....|.|||.:...:..|.:|...:|:
Mouse   489 -------------IAAFSYMMVW----MVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVAR 536

  Fly   501 HGYGKMAFGAIIGGSVYSLAVNVGIELVLQK---------KLNSRGQVVLYGDDGVTIYIFLVIT 556
            .|.|.||....||.:|:.:.:.:|:...||.         :|||||.:...|        .|:.:
Mouse   537 QGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVG--------LLLAS 593

  Fly   557 ITTTLW------WCLTFNFVARRSAG-LFMWSLFVLFLVYT 590
            :..|::      |.|.    .:...| ||::.:|:.|.:.|
Mouse   594 VFVTVFGVHLNKWQLD----KKLGCGCLFLYGVFLCFSIMT 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14743	NP_610408.2	ECM27	106..>221	CDD:440296	27/142 (19%)
		PLN03151	<337..529	CDD:215604	32/191 (17%)
		Na_Ca_ex	450..591	CDD:426387	38/157 (24%)
Slc24a3	NP_001343426.1	2A1904	<89..631	CDD:273344	117/626 (19%)
		Alpha-1	148..188		8/39 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..398		0/18 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..442		10/43 (23%)
		Alpha-2	520..551		9/30 (30%)