Protein Alignment CG14743 and ECM27

DIOPT Version :10

• Sequence 1: NP_610408.2
• Gene: CG14743 / 35860
• FlyBaseID: FBgn0033326
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_012640.4
• Gene: ECM27 / 853570
• SGDID: S000003867
• Length: 725
• Species: Saccharomyces cerevisiae
• Alignment Length: 735
• Identity: 127/735 - (17%)
• Similarity: 246/735 - (33%)
• Gaps: 244/735 - (33%)

  Fly    67 DNKIT-EIVVMLLFALIYCF---------FLC--ILY----EGVNSYFAPTLKIAALKMRINEYM 115
            |.|:: ..:|..||.:|..|         |||  :.:    ..:.|..:...|.|:........|
Yeast    16 DPKLSVTFIVPSLFHIIIAFVLLGICASDFLCPNVAHISDPNSLRSNGSLVSKTASHASHTGALM 80

  Fly   116 AGVVLVGVANSTPDLLVNL-----SPVRMEGLTFNIAMANAL----TIICLSGGAVCFIRP---- 167
            |  ||:...||:|||..||     |.......:.::::...|    .|:|:..|::..|..
Yeast    81 A--VLLSWCNSSPDLFSNLMSWATSTRETRSTSVSLSIGEVLGACGIILCIVEGSIFIIMSRTHI 143

  Fly   168 --FRMNGHSIFRDLLFLLLIIELVRF--FMNDTALAPWIKGAILLSIYPIYLLINIVDLILLRYA 228
              .::...||.|||||.|..:.::.:  .||...:   :...::..:|..||::.:.  ..|.::
Yeast   144 EISQIQKLSIMRDLLFSLAAMCVMSYVSLMNQVTV---LNCLLMAFLYAFYLVVKLT--FKLNHS 203

  Fly   229 IR---KLRADIEVLRQSPSSREHDLILTE----------------------------------KI 256
            ..   :..||..:...|.|....|.::..                                  .:
Yeast   204 AETPDETAADTSLRENSVSPFLDDSLMASGLLPPIQPGFDISNSITHGIKPSLLSAMDFNSFLSM 268

  Fly   257 VRLNNLQQDD------EIQILESKL-------------------------------YR--KRTYN 282
            :..::|::||      |:..|.|..                               ||  :|..|
Yeast   269 LENSSLEEDDSRNEMAELNTLRSMTPGQHWSASATVAGEATSAGRPFSEPTNAFTEYRDSERAIN 333

  Fly   283 AGFFVTPKPLIHHKE--VDVETNRRIL-----HSKANPKNLFLFSEFLQAINPIDSEGW------ 334
            :    :|.....:::  .|.|:..::|     |.....:.:..||:        .|.||
Yeast   334 S----SPAVFAPYRDNPDDEESQEQVLLETTTHGHFGAQEMRRFSK--------RSLGWIIKIFI 386

  Fly   335 -YLSGTCAR-----ILQILKAPVTLMLHLVVP-----LVDYQLVKHGWSKMLNCLQIVL------ 382
             :||....:     |..|:..|..::..|..|     ::.|....:.:|  |..|.|:|
Yeast   387 PHLSNFSQKSISDAIFSIITVPFFIIFKLSCPQPPSDILSYDPTLNRYS--LTTLPIILLFIQSI 449

  Fly   383 -TPFVIFALVETMLVHKYAEWYYVPQFRMAIWSLLVTMPLAIVVFLHSRTDIPPFYHSS------ 440
             .||::.:::..:|.:......|:....:|:..:|:.......|.||::..:.  ..||
Yeast   450 TAPFLLCSILSVLLTYHLGYLVYLFPLILAMALILLLTAFITKVNLHNKFTLS--LDSSNILQEK 512

  Fly   441 -----------------YCALTISTVIIFFWICAWEMDALISIIGVVFDLAPSYMSITFNSVSAA 488
                             :.|:.|..:||:..:.|..:..::.|...:..|:.:.:.:|..:...:
Yeast   513 LQKRKLLERLNTSIQIIFLAIGIINIIIWISLLANSLIEMMEIYQKILGLSKAILGLTIFAWGNS 577

  Fly   489 TADLIAYAHLAK------H---------GYGKMAFGAIIGGSVYSLAVNVGIELVLQKKLNSRGQ 538
            ..|||:...:.:      |         .:..::..:.:||.:                |||.|.
Yeast   578 VGDLISNISMCRLYKTQTHYQDRVRLATKFFMISCASCLGGVM----------------LNSMGG 626

  Fly   539 VVLYGDDGVTIYIFLVITITTTLWWCL-------------TFNFVARRSAGLFMWSLFVLFLVYT 590
            :   |..|:...:| :.......||.|             |.|:....|....:..:.:|.|.:
Yeast   627 I---GFSGLVSMLF-IGAFNDNEWWFLRKVKLQETSQLDNTLNYKFIVSCVFIILQIILLLLFF- 686

  Fly   591 TAIELQWVHGFQDNIQIRPT 610
                     |..:||:.|.|
Yeast   687 ---------GGPNNIKRRLT 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14743	NP_610408.2	ECM27	106..>221	CDD:440296	30/131 (23%)
		PLN03151	<337..529	CDD:215604	37/246 (15%)
		Na_Ca_ex	450..591	CDD:426387	27/168 (16%)
ECM27	NP_012640.4	Na_Ca_ex	27..196	CDD:426387	40/173 (23%)
		PLN03151	<544..637	CDD:215604	16/111 (14%)