DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14743 and Slc24a2

DIOPT Version :9

Sequence 1:	NP_610408.2	Gene:	CG14743 / 35860	FlyBaseID:	FBgn0033326	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_113931.1	Gene:	Slc24a2 / 84550	RGDID:	628650	Length:	670	Species:	Rattus norvegicus

Alignment Length:	601	Identity:	118/601 - (19%)
Similarity:	228/601 - (37%)	Gaps:	136/601 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 FKIDNKITEIVVMLLFALIYCFF-LCILYEGVNSYFAPTLKIAALKMRINEYMAGVVLVGVANST 127
            |.::.:....:::.:..:||.|. |.|:   .:.:|.|:|.:...|:.|::.:||...:....|.
  Rat   126 FSLEERRKGAIILHVIGMIYMFIALAIV---CDEFFVPSLTVITEKLGISDDVAGATFMAAGGSA 187

  Fly   128 PDLLVNLSPVRME------GLTFNIAMANALTIICLSGGAVCFIRP-FRMNGHSIFRDLLFLLL- 184
            |:|..:|..|.:.      |.....|:.|.|.:|   |....|.|. ..:....:|||:.|.::
  Rat   188 PELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVI---GMCALFSREILNLTWWPLFRDVSFYIVD 249

  Fly   185 IIELVRFFMNDTALAPWIKGAILLS---IYPIYLLINI-----VDLILLRYAIRKLRADIEVLRQ 241
            :|.|:.||:::..:  |.:..:||:   .|.:::..|:     |..::.|..:.|:.......:.
  Rat   250 LIMLIIFFLDNVIM--WWESLLLLTAYFAYVVFMKFNVQVERWVKQMINRNKVVKVTVSEAQAKA 312

  Fly   242 SPSSREHDLILTEKIVRL----------NNLQQDDEIQIL---------ESKLYRKRTY-----N 282
            |.:..:.:..|..| .||          |:|.::...|::         |...|.|..|     .
  Rat   313 STAGDKEEPTLPNK-PRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTE 376

  Fly   283 AGFFVTPKPLIH---HKEVDVETNRRILHSKAN-----------PKNLFLFSEFL---QAINPID 330
            .|.|.....::|   .|:..|:.|.| .:..||           |.:.....|..   :|..|:.
  Rat   377 EGRFREKASILHKIAKKKCQVDENER-QNGAANHVDYAAEKIELPNSTSTEVEMTPSSEASEPVQ 440

  Fly   331 SEGWYLSGTCARILQILKAPVTLMLHLVVPLVDYQLVKHGW----SKMLNCLQIVLTPFVIFALV 391
                  :|..:..::...||....   .....|.|.:...|    .|.:..| |||.  ::|.|
  Rat   441 ------NGNLSHSIEAADAPQATE---TAEEDDDQPLSLSWPSNTRKQITFL-IVLP--IVFPL- 492

  Fly   392 ETMLVHKYAEWYYVPQFRMAIWSLLVTMPLAIVVFLHSRTDIPPFYHSSYCALTISTVIIFFWIC 456
                      |..:|..|...                |:...|..:..|     |:.:.:|.::.
  Rat   493 ----------WITLPDVRKPA----------------SKKFFPITFFGS-----ITWIAVFSYLM 526

  Fly   457 AWEMDALISIIGVVFDLAPSYMSITFNSVSAATADLIAYAHLAKHGYGKMAFGAIIGGSVYSLAV 521
            .|....:...||:    :...|.:|..:...:..|||....:|:.|.|.||..:.:|.:::.:.|
  Rat   527 VWWAHQVGETIGI----SEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITV 587

  Fly   522 NVGIELVLQKKLNSRGQVVLYGDDGV--------TIYIFLVITITTTLWWCLTFNFVARRSAGLF 578
            .:.:..:|...:: |.:.|....:|:        .:.||::::|....|       ...:..|..
  Rat   588 GLPLPWLLYTIIH-RFKPVTVSSNGLFCAIVLLFIMLIFVILSIALCKW-------RMNKILGFI 644

  Fly   579 MWSLFVLFLVYTTAIE 594
            |:.|:..|||.:..:|
  Rat   645 MFGLYFAFLVVSVLLE 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14743	NP_610408.2	Na_Ca_ex	77..220	CDD:279963	38/159 (24%)
CG14743	NP_610408.2	Na_Ca_ex	450..591	CDD:279963	30/148 (20%)
Slc24a2	NP_113931.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..86
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..122
		TIGR00367	138..652	CDD:273039	113/579 (20%)
		Na_Ca_ex	139..281	CDD:279963	37/149 (25%)
		Alpha-1	175..215		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..335		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..414		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	450..471		4/23 (17%)
		Na_Ca_ex	507..658	CDD:279963	33/167 (20%)
		Alpha-2	550..581		9/30 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810