DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14743 and slc24a2

DIOPT Version :9

Sequence 1:	NP_610408.2	Gene:	CG14743 / 35860	FlyBaseID:	FBgn0033326	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_017211234.1	Gene:	slc24a2 / 751686	ZFINID:	ZDB-GENE-060825-277	Length:	628	Species:	Danio rerio

Alignment Length:	588	Identity:	117/588 - (19%)
Similarity:	215/588 - (36%)	Gaps:	148/588 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 FKIDNKITEIVVMLLFALIYCFF-LCILYEGVNSYFAPTLKIAALKMRINEYMAGVVLVGVANST 127
            |.::.:....||:.:|.::|.|. |.|:   .:.:|.|.|.:...|:.|::.:||...:....|.
Zfish   122 FTLEQRRQGAVVLHMFGMMYMFIALAIV---CDEFFVPALTVITEKLEISDDVAGATFMAAGGSA 183

  Fly   128 PDLLVNLSPVRME------GLTFNIAMANALTIICLSGGAVCFIRP-FRMNGHSIFRDLLFLLL- 184
            |:|..::..|.:.      |.....|:.|.|.:|   |....|.|. ..:....:|||:.|.::
Zfish   184 PELFTSVIGVFISHSNVGIGTIVGSAVFNILFVI---GMCALFSREILNLTWWPLFRDVSFYIIG 245

  Fly   185 IIELVRFFMNDTALAPWIKGAILLSIYPIY-----------------LLINIVD-------LILL 225
            :|.|:.||:::  ...:::...|||.|..|                 ||.|.||       ::.:
Zfish   246 LIMLIVFFLDN--YITYVESFALLSCYGSYVTFMKFNSSVETWIKTRLLGNQVDDIEAPPKVVSV 308

  Fly   226 RYAIRKLRADIEVLRQSPSSREHDLILTEKIVRL--NNLQQDDEIQILES-----KLYRKRTYNA 283
            .....||.|...:.|...|:..|:.::...|.:|  :.|....|.:..|.     |:.||:..:.
Zfish   309 PDDENKLSAKPRLQRGGSSASLHNTLMRNSIFQLMIHTLDPLSEGKFKEKASILHKIARKKGQDE 373

  Fly   284 G---------FFVTPKPLIHHKEVDVETNRRILHSKANPKNLFLFSEFLQAINPIDSEGWYLSGT 339
            .         ..:..|.|.:...|:||.... ::..|.|:        ::.....:.|...||
Zfish   374 ANGVEDGQRKCMLMDKNLPNSSNVEVEVTPP-MNGSAGPE--------VEVEEEEEDEDQPLS-- 427

  Fly   340 CARILQILKAPVTLMLHLVVPLVDYQLVKHGWSKMLNCLQIVLTPFVIFALVETMLVHKYAEWYY 404
                   |..|.|:...                         :|...||.:|       :..|..
Zfish   428 -------LAWPDTIRKQ-------------------------VTYLFIFPIV-------FPLWLS 453

  Fly   405 VPQFRMAIWSLLVTMPLAIVVFLHSRTDIPPFYHSSYCALTISTVIIFFWICAWEMDALISIIGV 469
            :|..|..                .||...|..:..|     ||.:..|.::..|....:...||:
Zfish   454 LPDVRRE----------------SSRKFFPVTFLGS-----ISWIAFFSYLMVWWAHQVGETIGI 497

  Fly   470 VFDLAPSYMSITFNSVSAATADLIAYAHLAKHGYGKMAFGAIIGGSVYSLAVNVGIELVLQKKLN 534
            ..::    |.:|..:...:..|||....:|:.|.|.||..:.:|.:::.:.|.:....:|...||
Zfish   498 TEEI----MGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPFPWLLFSMLN 558

  Fly   535 SRGQVVLYGDDGV--------TIYIFLVITITTTLWWCLTFNFVARRSAGLFMWSLFVLFLVYTT 591
            ....|.: ..:|:        .:.:|::|:|....|       ...:..|..|:.|:.:|||.:.
Zfish   559 DFSSVAV-SSNGLFCAIVLLFLMLLFVIISIAVCKW-------KMSKMLGFLMFLLYFVFLVVSV 615

  Fly   592 AIE 594
            .:|
Zfish   616 MLE 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14743	NP_610408.2	Na_Ca_ex	77..220	CDD:279963	40/168 (24%)
CG14743	NP_610408.2	Na_Ca_ex	450..591	CDD:279963	31/148 (21%)
slc24a2	XP_017211234.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810