Protein Alignment CG14743 and SLC24A5

DIOPT Version :9

• Sequence 1: NP_610408.2
• Gene: CG14743 / 35860
• FlyBaseID: FBgn0033326
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_995322.1
• Gene: SLC24A5 / 283652
• HGNCID: 20611
• Length: 500
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 99/521 - (19%)
• Similarity: 187/521 - (35%)
• Gaps: 168/521 - (32%)

  Fly    82 IYCFFLCILYEGV------NSYFAPTLKIAALKMRINEYMAGVVLVGVANSTPDLL--------- 131
            |..:||.|:|..:      :.||.|:|:|.:..:.:::.:||...:...:|.|:|:
Human    69 IIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFIT 133

  Fly   132 ---VNLSPVRMEGLTFNIAMANALTIICLSGGAV--------CFIRPFRMNGHSIFRDLLFLLLI 185
               :.:|.:      ...|:.|.|. ||.:.|.:        |:         .:|||.....:.
Human   134 KGDIGISTI------LGSAIYNLLG-ICAACGLLSNTVSTLSCW---------PLFRDCAAYTIS 182

  Fly   186 IELVRFFMNDTALAPWIKGAILLSIYPIYLLINIVDLILLRYAIRKLRADIEVLRQSPSSREHDL 250
            ...|...:.|..:. |.:||:||.||.:|:|:...|:.:.:|.|:|.......|.::....|...
Human   183 AAAVLGIIYDNQVY-WYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAMERSEQQP 246

  Fly   251 ILTEKIVRLNNLQQDDEIQILESKLYRKRTYNAGFFVTPKPLIHHKEVDVETNRRILHS----KA 311
            :          :..:||.|..   :.|:...::|.|....   .:.::.:.     ||.    ..
Human   247 L----------MGWEDEGQPF---IRRQSRTDSGIFYEDS---GYSQLSIS-----LHGLSQVSE 290

  Fly   312 NPKNLFLFSEFLQAINPIDSEGWYLSGTCARILQILKAPVTLMLHLVVPLVDYQLVKHGWSKMLN 376
            :|.::|...|                ....||..:|..|:..:|.|..|               :
Human   291 DPPSVFNMPE----------------ADLKRIFWVLSLPIITLLFLTTP---------------D 324

  Fly   377 CLQIVLTPFVIFALVETMLVHKYAEWYYVPQFRM-AIWSLLVTMPLAIVVFLHSRTDIPPFYHSS 440
            |.:                  |:.:.|:|..|.| |||
Human   325 CRK------------------KFWKNYFVITFFMSAIW--------------------------- 344

  Fly   441 YCALTISTVIIFFWICAWEMDALISIIGVVFDLAPSYMSITFNSVSAATADLIAYAHLAKHGYGK 505
                    :..|.:|..|    :::|.|...::..:.|.:|..:...:..|.||...:|:.|.|.
Human   345 --------ISAFTYILVW----MVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGD 397

  Fly   506 MAFGAIIGGSVYSLAVNVGIELVLQ---------KKLNSRGQVVLYGDDGVTIYIFLVITITTTL 561
            ||...|:|.:|:.: :.:||...::         .::||||...:.....::| |||.:.:....
Human   398 MAMSNIVGSNVFDM-LCLGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISI-IFLFLAVHFNG 460

  Fly   562 W 562
            |
Human   461 W 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14743	NP_610408.2	Na_Ca_ex	77..220	CDD:279963	37/163 (23%)
		Na_Ca_ex	450..591	CDD:279963	29/122 (24%)
SLC24A5	NP_995322.1	Na_Ca_ex	<20..>224	CDD:332332	38/171 (22%)
		Na_Ca_ex	<290..490	CDD:332332	48/262 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810