Protein Alignment CG14743 and Slc24a4

DIOPT Version :9

• Sequence 1: NP_610408.2
• Gene: CG14743 / 35860
• FlyBaseID: FBgn0033326
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_742164.2
• Gene: Slc24a4 / 238384
• MGIID: 2447362
• Length: 622
• Species: Mus musculus
• Alignment Length: 600
• Identity: 124/600 - (20%)
• Similarity: 232/600 - (38%)
• Gaps: 172/600 - (28%)

  Fly    74 VVMLLFALIYCFF-LCILYEGVNSYFAPTLKIAALKMRINEYMAGVVLVGVANSTPDLLVNLSPV 137
            |::.:...:|.|: |.|:   .:.:|.|:|:....|:.::|.:||...:...:|||:|..::..|
Mouse   100 VLLHILGALYMFYALAIV---CDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGV 161

  Fly   138 RME------GLTFNIAMANALTIICLSGGAVCFI---RPFRMNGHSIFRD-LLFLLLIIELVRFF 192
            .:.      |.....|:.|   |:|:.|  ||.:   :..|:...::.|| :.:.|.:|.|:.|.
Mouse   162 FITHGDVGVGTIVGSAVFN---ILCIIG--VCGLFAGQVVRLTWWAVCRDSVYYTLSVIVLIAFI 221

  Fly   193 MNDTALAPWIKGAILLSIYPIYLLINIVDLILLRYAIRKLRA---------------DI------ 236
            .::..:  |.:|.:|:.:|..|:||...::.:..:...|.::               |:
Mouse   222 YDEEIV--WWEGLVLIILYVFYILIMKYNMKMQTFFTTKQKSIANGNPVSNELEDGNDLYDGSYD 284

  Fly   237 -------------------------EVLRQSPSSREHD-----LILTEKIVRLNNLQQDDEIQIL 271
                                     |:|..||......     :::|.|......|:....|.|.
Mouse   285 DPSVPLLGQVKEKPPYGKTPVVMVDEILSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIIN 349

  Fly   272 ESKLYRKRTYNAGFFVTPKPLIHHKEVDVETNRRILHSKANPKNLFLFSEFLQAINPIDSEGWYL 336
            |    |:|..|:...|..|||.:.:..::|.....:.:..:|:                 :|
Mouse   350 E----RQRLINSANGVNSKPLQNGRHENMENGNVPVENPEDPQ-----------------QG--- 390

  Fly   337 SGTCARILQILKAPVTLMLHLVVPLVDYQLVKHGWSKMLNCLQIVLTPFVIFALVETMLVHKYAE 401
                    |..:.|..      .|..:.:.|:          .:.|:|   |::.|..  ...|:
Mouse   391 --------QEQQPPPQ------PPPPEPESVE----------TVFLSP---FSMPEAK--GDKAK 426

  Fly   402 WYYVPQFRMAIWSLL----VTMPLAIVVFLHSRTDIPPFYHSSYCALTISTVIIFFWICAWEMDA 462
            |.:.       |.|:    ||:|..      |:.....|:..::...|: .:.:|.::..|
Mouse   427 WVFT-------WPLIFLLCVTIPNC------SKPRWEKFFMVTFITATL-WIAVFSYLMVW---- 473

  Fly   463 LISIIGVVFDLAPSYMSITFNSVSAATADLIAYAHLAKHGYGKMAFGAIIGGSVYSLAVNVGIEL 527
            |::|||....:....|.|||.:...:..|.:|...:|:.|.|.||....||.:|:.:.|.:||..
Mouse   474 LVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIPW 538

  Fly   528 VLQK---------KLNSRG----QVVLYGDDGVTIYIFLVITITTTLWWCLTFNFVARRSAGLFM 579
            .||.         |:||||    .|:|.|...:|:   |.|.:..   |.|.      |..|:::
Mouse   539 GLQTMVINYGSTVKINSRGLVYSVVLLLGSVALTV---LGIHLNK---WRLD------RKLGIYV 591

  Fly   580 WSLFVLFLVYTTAIE 594
            ..|:.:||.::..||
Mouse   592 LVLYAVFLCFSIMIE 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14743	NP_610408.2	Na_Ca_ex	77..220	CDD:279963	38/153 (25%)
		Na_Ca_ex	450..591	CDD:279963	43/153 (28%)
Slc24a4	NP_742164.2	Na_Ca_ex	<80..606	CDD:332332	122/598 (20%)
		Alpha-1	139..179		9/39 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	358..408		10/83 (12%)
		Alpha-2	495..526		9/30 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810