DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14743 and ncx-6

DIOPT Version :9

Sequence 1:	NP_610408.2	Gene:	CG14743 / 35860	FlyBaseID:	FBgn0033326	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_499146.2	Gene:	ncx-6 / 182354	WormBaseID:	WBGene00003571	Length:	590	Species:	Caenorhabditis elegans

Alignment Length:	540	Identity:	115/540 - (21%)
Similarity:	220/540 - (40%)	Gaps:	82/540 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 VVMLLFALIYCFFLCILY-EGVNSYFAPTLKIAALKMRINEYMAGVVLVGVANSTPDLL-----V 132
            :::::..:||...|.|:. ...:.:|:|::......:||:|.:|||..:...|..||:.     |
Worm    97 IILIITGVIYMLVLFIMVSSAADDFFSPSISSIVAHLRISESVAGVTFMAFGNGAPDVFGAIASV 161

  Fly   133 NLSPVRMEGLTFNIAMANALTIICLSGGAVCFIRPFRMNGHSIFRDLLFLLLIIELVRF-FMNDT 196
            ..||.....|.........|.:..:......|.|||:....|..||:.|.|:.:..:.| |:...
Worm   162 LSSPTPKADLALGELFGAGLFVTTMVLAVTIFTRPFKAEVFSSIRDIAFYLVALAFLAFCFVYYD 226

  Fly   197 ALAPWIKGAILLSIYPIYLLINIVDLILLRYAIRKLRADIEVLRQSPSSREHDLILTEKIVRLNN 261
            .:..|:. ...|.:|.||:...|:..||                .:...::.:.:...|.|..::
Worm   227 HVEIWMP-ITFLGVYLIYVCTVILSQIL----------------HNRHKKDEEKVDEVKTVDTDS 274

  Fly   262 LQQDDEIQILESKLYRKRTYNAGFFVTPKPLIHHKEVDVE--------TNRRILHSKANPKNLFL 318
            |:.||:|.:           :.|..|.....:...|.::|        :.|.::|.
Worm   275 LEDDDDIYV-----------SHGHHVLHAHEVMKMEAEIEAVEPLKTWSFRGVVHD--------- 319

  Fly   319 FSEFLQAINPIDSEGWYLSGTCARILQILKAPVTLMLHLVVPLVDYQLVKHG---WSKMLNCLQI 380
            |.|.|:....:|.  |.......:::.:|......:..|.:|        |.   |||.:..||.
Worm   320 FKEHLKPWPSMDE--WDEMNIFQKVIAVLNTIPNFLFKLTIP--------HSEQPWSKPITLLQC 374

  Fly   381 VLTPFVIFALVETMLVHKYAE----WYYVPQFRMAIWSLLVTMPLAIVVFLHSRTDIPPFYHS-- 439
            ::.|..:...::...:..:..    |.|     ..|.|:|:|..:.....||..   ||||.|
Worm   375 LICPVFLLFCIQVCSISPFPNSPGLWMY-----GLILSVLLTAAVLFFTELHKE---PPFYKSLI 431

  Fly   440 SYCALTISTVIIFFWICAWEMDALISIIGVVFDLAPSYMSITFNSVSAATADLIAYAHLAKHGYG 504
            ||....:|  |.:.::.:.|:..:::::|||..::...:.:|..:.|.:..||||...:||.||.
Worm   432 SYAGFLMS--IAWIYLISSEVVNVVTMLGVVSRVSHEVLGLTILAWSNSIGDLIADVSVAKQGYP 494

  Fly   505 KMAFGAIIGGSVYSLAVNVGIELVLQKKLNSRGQVVLYGDDGVTIYIFLVITITTTLWWCLTFNF 569
            :||..|.|||.:::|.:..|:...: .|:..:...::.......:.:||.|::..||.......:
Worm   495 RMAMAAAIGGQLFNLLIGFGLPFTI-AKIQGKSISMIINPTYRLLMLFLAISLIFTLIAMFAQKY 558

  Fly   570 VARRSAGLFMWSLFVLFLVY 589
            ..||.....:..:::.|.|:
Worm   559 FLRRIHSYSLVFIYISFFVF 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14743	NP_610408.2	Na_Ca_ex	77..220	CDD:279963	36/149 (24%)
CG14743	NP_610408.2	Na_Ca_ex	450..591	CDD:279963	33/140 (24%)
ncx-6	NP_499146.2	Na_Ca_ex	105..249	CDD:279963	36/144 (25%)
ncx-6	NP_499146.2	Na_Ca_ex	431..579	CDD:279963	36/151 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165708
Domainoid	1	1.000	75	1.000	Domainoid score	I5893
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41602
Inparanoid	1	1.050	162	1.000	Inparanoid score	I2840
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		mtm4752
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.720