DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14743 and ncx-7

DIOPT Version :9

Sequence 1:	NP_610408.2	Gene:	CG14743 / 35860	FlyBaseID:	FBgn0033326	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_499147.3	Gene:	ncx-7 / 176370	WormBaseID:	WBGene00003572	Length:	672	Species:	Caenorhabditis elegans

Alignment Length:	704	Identity:	144/704 - (20%)
Similarity:	273/704 - (38%)	Gaps:	149/704 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLKYLINTSPYSFLNESDFMQNVSCLAVMHFSYLHRCEMA---TKIDDCKYIT---------NF 53
            ::|.:||:.........:.|.:..:|..   :....:||:.   |:...|.|:.         .:
Worm    10 LTLIFLISIKSCDAKYRTSFFKTPNCSI---YPDAEKCELNKTWTQEQVCDYVNCNDNACEGGGY 71

  Fly    54 FNYYVMMYCSFKIDNKITEIVVMLLFALIYCFFLCILY-EGVNSYFAPTLKIAALKMRINEYMAG 117
            ..:...:.|:....::    |::::..:||...|.|:. ...:.:|:|::......:||:|.:||
Worm    72 LLWTQYVECASSTFSR----VILIIVGVIYMLVLFIMVSSAADDFFSPSISSIVAHLRISESVAG 132

  Fly   118 VVLVGVANSTPDLLVNL-----SPVRMEGLTFNIAMANALTIICLSGGAVCFIRPFRMNGHSIFR 177
            |..:...|..||:..::     ||.....|.........|.:..:....:....||.:...|..|
Worm   133 VTFMAFGNGAPDVFGSIASVLSSPTPKADLALGELFGGGLFVTTMVVSTIILTSPFDVEVFSTIR 197

  Fly   178 DLLFLLLIIELVRF---FMNDTALAPWIKGAILLSIYPIYLLI--------NIVDLILLRYAIRK 231
            ||||.|:.:..:.|   |.|...|  |:. ...|.:|.:|::.        |.....|.:....|
Worm   198 DLLFYLVALSFLAFCFVFYNRVTL--WMP-LTFLGLYLLYVITVIGAQAVHNRKRKALQKQNSTK 259

  Fly   232 LRADIEVLRQS------------PSSREHD--------LILTEKIVRLNNLQQDDEIQILESKLY 276
            .|..|:.||..            |....||        .::|..|.:|.      |....:::..
Worm   260 SRKSIKSLRSRKSIHSVAPMPVIPEIEVHDQEAPFPEISVVTGAIDKLK------EHMAEKAQTT 318

  Fly   277 RKRTYNAGFFVTP-------KPLIHHKEVDVETNRR------------ILHS------KANPKNL 316
            |:.|..|.|.|..       .|...|..:.:  :||            ::|.      :|..:..
Worm   319 RRYTKRASFMVNGDGNLNGLHPYATHNHLGI--SRRESELSDEDEEFVVIHGHVFQGHEARSRAA 381

  Fly   317 FLFSEFLQA---------------INP-IDSEGWYLSGTCARILQILKAPVTLMLHLVVPLVDYQ 365
            .|..|.:|.               ::| .::|.|......::::..:.....|:..|.:||.:.
Worm   382 SLVPEPMQIKSWRSKDILKDLAEHLDPRPEAEDWEEMNIFSKVMAYINVVPNLLFKLTIPLNEM- 445

  Fly   366 LVKHGWSKMLNCLQIVLTP-FVIFAL---VETMLVHKYAEWYYVPQFRMAIWSLLVTMPLAIVVF 426
                .|||.|..|.....| |::|::   :||........|.|         .|.|::.|||::.
Worm   446 ----SWSKPLTLLHAFTCPAFLLFSIQFFLETPFSGSPGLWVY---------GLAVSIVLAILIM 497

  Fly   427 LHSRTDIPPFYHS---SYCALTISTVIIFFWICAWEMDALISIIGVVFDLAPSYMSITFNSVSAA 488
            :.:...:.|.|:.   ||....:|  |.:.::.:.|:..:::::|||..::...:.:|..:.|.:
Worm   498 VFTELSVQPKYYKEIYSYSGFIMS--IAWIYLISSEVVNVVTMLGVVSRVSHEVLGLTILAWSNS 560

  Fly   489 TADLIAYAHLAKHGYGKMAFGAIIGGSVYSLAVNVGIELVLQKKLNSRGQVVLYGDDGVTI---- 549
            ..||||...:.|.||.:||..|.|||.:::|.:..|:...:.|   .:|:.:     .:||
Worm   561 IGDLIADVSVVKQGYPRMAMAAAIGGPLFNLLMGFGLPFTIAK---LQGKYI-----SMTINPTY 617

  Fly   550 ---YIFLVITITTTLWWCLTFNFVARRSAGLFMWSLFVLFLVYTTAIE---LQW 597
               .:||.|::..||.......|..:|.....:.|:::.|:|:....|   |.|
Worm   618 RLLILFLAISLLATLIGIPVQKFRLQRPHAAVLISIYIAFIVFVILSETGVLVW 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14743	NP_610408.2	Na_Ca_ex	77..220	CDD:279963	37/159 (23%)
CG14743	NP_610408.2	Na_Ca_ex	450..591	CDD:279963	36/147 (24%)
ncx-7	NP_499147.3	PLN03151	56..671	CDD:215604	135/653 (21%)
		Na_Ca_ex	96..240	CDD:279963	36/146 (25%)
		Na_Ca_ex	513..663	CDD:279963	39/159 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165709
Domainoid	1	1.000	75	1.000	Domainoid score	I5893
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41602
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		mtm4752
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.670