Protein Alignment CG14743 and Slc8b1

DIOPT Version :10

• Sequence 1: NP_610408.2
• Gene: CG14743 / 35860
• FlyBaseID: FBgn0033326
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_573484.2
• Gene: Slc8b1 / 170756
• MGIID: 2180781
• Length: 585
• Species: Mus musculus
• Alignment Length: 598
• Identity: 143/598 - (23%)
• Similarity: 258/598 - (43%)
• Gaps: 93/598 - (15%)

  Fly    26 CLAVMHFSYLHRCEMATKIDDCKYITNFFNYYVMMYCSFKIDNKITEIVVMLLFALIYCFFLCIL 90
            |.||...:...||:...:..||:....:.:|...::|.|. .|.:...:.:.:|.|:|.|.:.
Mouse    53 CRAVCGLNTSDRCDFVRRNPDCRSEAGYLDYLEGIFCYFP-PNLLPLAITLYVFWLLYLFLIL-- 114

  Fly    91 YEGVNS--YFAPTLKIAALKMRINEYMAGVVLVGVANSTPDL---LVNLSPVRMEGLTFNIAMAN 150
              ||.:  :|.|.|...:..::::..:|||..:...|..||:   ||..|..|..||........
Mouse   115 --GVTAAKFFCPNLSAISTNLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPRTAGLAIGALFGA 177

  Fly   151 ALTIICLSGGAVCFIRPFRMNGHSIFRDLLFLLLIIELVRFFMNDTAL------APWIKGAILLS 209
            .:.:..:..|.:..:.||........||:.|.::.:     |:..|||      ..|..|  .|.
Mouse   178 GVLVTTVVAGGITILHPFMAASRPFLRDIAFYMVAV-----FLTFTALYLGRITLTWALG--YLG 235

  Fly   210 IYPIYLLINIVDLILLRYAIRKLRADIEVLRQSPSSREHDLILTEKIVRLNNLQQDDEIQILESK 274
            :|..|    :|.:|:..:..:         ||...|..|.:..|.::     |.:.:|.|:..:
Mouse   236 LYVFY----VVTVIICTWVYQ---------RQRSRSLVHSISETPEL-----LSESEEDQMSSN- 281

  Fly   275 LYRKRTYNAGFFVTPKPLIHHKEVDVETNRRILHSKANPKNLFLFSEFLQAINPIDSEGWYLSGT 339
               ..:|:.|  ...:||:..:|..|:.                   .:||:||:|...|.....
Mouse   282 ---TNSYDYG--DEYRPLLLGRETTVQI-------------------LIQALNPLDYRKWRTQSI 322

  Fly   340 CARILQILKAPVTLMLHLVVPLVDYQLVKHGWSKMLNCLQIVLTPFVIFALVETMLVHKYAEWYY 404
            ..|:|:::|.||..:|.|.||:||.......|.:.|||||:|::|.|:...:::.:...|.....
Mouse   323 SWRVLKVVKLPVEFLLLLTVPVVDPDKDDRNWKRPLNCLQLVISPLVLVLTLQSGVYGIYEIGGL 387

  Fly   405 VPQFRMAIWSLLVTM--PLAIVVFLHSRTDIPPFYHSSYCALTISTVIIFFWICAWEMDALISII 467
            :|     :|:::|.:  .||.|.|..:....||..|..:..|...|..::....|.|:..::..:
Mouse   388 LP-----VWAVVVIVGTALASVTFFATSNREPPRLHWLFAFLGFLTSALWINAAATEVVNILRSL 447

  Fly   468 GVVFDLAPSYMSITF----NSVSAATADLIAYAHLAKHGYGKMAFGAIIGGSVYSLAVNVGIELV 528
            ||:|.|:.:.:.:|.    ||:..|.:|..    ||:.||.:|||.|..||.::::.|.||:..:
Mouse   448 GVIFRLSNTVLGLTLLAWGNSIGDAFSDFT----LARQGYPRMAFSACFGGIIFNILVGVGLGCL 508

  Fly   529 LQKKLNSRGQVVLYGDDGVTIYIF-------LVITITTTLWWCLTFNFVARRSAGLFMWSLFVLF 586
            ||...|...:|.| ..||:.:::.       |:.::.:....|    |...::.||.:...::.|
Mouse   509 LQIIRNHVVEVKL-EPDGLLVWVLASALGLSLIFSLVSVPLQC----FQLSKAYGLCLLLFYICF 568

  Fly   587 LVYTTAIELQWVH 599
            ||.....|...:|
Mouse   569 LVVVLLTEFGVIH 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14743	NP_610408.2	ECM27	106..>221	CDD:440296	27/123 (22%)
		PLN03151	<337..529	CDD:215604	57/197 (29%)
		Na_Ca_ex	450..591	CDD:426387	39/151 (26%)
Slc8b1	NP_573484.2	PLN03151	63..580	CDD:215604	139/585 (24%)