DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14743 and slc24a4

DIOPT Version :9

Sequence 1:	NP_610408.2	Gene:	CG14743 / 35860	FlyBaseID:	FBgn0033326	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_002933272.2	Gene:	slc24a4 / 100489343	XenbaseID:	XB-GENE-478288	Length:	612	Species:	Xenopus tropicalis

Alignment Length:	586	Identity:	118/586 - (20%)
Similarity:	219/586 - (37%)	Gaps:	141/586 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 FKIDNKITEIVVMLLFALIYCFF-LCILYEGVNSYFAPTLKIAALKMRINEYMAGVVLVGVANST 127
            |.|..:....|:..:|..:|.|: |.|:   .:.:|.|:|:....|:.::|.:||...:...:||
Frog    97 FSIKERQRGAVLFHIFCALYMFYALAIV---CDDFFVPSLEKICEKLHLSEDVAGATFMAAGSST 158

  Fly   128 PDLLVNLSPVRME------GLTFNIAMANALTIICLSGGAVCFI---RPFRMNGHSIFRDLLFLL 183
            |:|..::..|.:.      |.....|:.|   |:|:.|  ||.:   :..|:...|:|||.::.:
Frog   159 PELFASVIGVFITHGDVGVGTIVGSAVFN---ILCIIG--VCGVFAGQVVRLTWWSLFRDSMYYI 218

  Fly   184 LIIELVRFFMNDTALAPWIKGAILLSIYPIYLLINIVDLILLR-YAIRKLRADIEVLRQSPSSRE 247
            :.|..:..|:.|..:. |.:..||:.:|..|:||...:..:.| :.|:|     .|....|...|
Frog   219 ISILALIIFIYDEIIV-WWESLILIVMYFFYILIMKYNTKMQRLFTIKK-----NVGNGCPVGSE 277

  Fly   248 -------HDLILTEKIVRL-------------NNLQQDDEIQILESKLYRKRTYNAGFFVTPK-- 290
                   .|.:..:..|.|             |::...|||.......||.........:|.|
Frog   278 LQDGNVYSDFVCDDPSVPLLWKVKASQQYYNRNSVVMVDEIICSSPPKYRFPEAGLRIMITNKFP 342

  Fly   291 ---PLIHHKEVDVETNRRILHSKANPKNLFL--FSEFLQ----AINPID-----SEGWYL----- 336
               .|.....:.:...:|:|||........|  ..|.|:    .::..|     :|..||
Frog   343 PRTRLRMASRLIINERQRLLHSANGTSTTTLDGKQELLENGGLHVDKADDYQEENEANYLVPFSV 407

  Fly   337 -SGTCARILQ-ILKAPVTLMLHLVVPLVDYQLVKHGWSKMLNCLQIVLTPFVIFALVETMLVHKY 399
             || ||.|.: ....|:..:|:..:|               ||.:                 .::
Frog   408 PSG-CANIFKWAFSWPLICILYFTIP---------------NCSK-----------------PRW 439

  Fly   400 AEWYYVPQFRMAIWSLLVTMPLAIVVFLHSRTDIPPFYHSSYCALTISTVIIFFWICAWEMDALI 464
            ..::.:......:|                                   :.||.:|..|    ::
Frog   440 ENFFMLTFITSTLW-----------------------------------IAIFSYIMVW----MV 465

  Fly   465 SIIGVVFDLAPSYMSITFNSVSAATADLIAYAHLAKHGYGKMAFGAIIGGSVYSLAVNVGIELVL 529
            ::||....:....|.|||.:...:..|.:|...:|:.|.|.||....||.:|:.:.|.:|:...|
Frog   466 TVIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNSIGSNVFDILVGLGVPWGL 530

  Fly   530 QKKLNSRGQVVLYGDDGVTIYIFLVI-TITTTLWWCLTFNFVARRSAGLFMWSLFVLFLVYTTAI 593
            |..:.:.|..|.....|:...:.|:: ::..|:.......:...:..|.::..|:.:||.::..|
Frog   531 QTMIINYGSTVKINSKGLVYSVILLLGSVALTVGGIYVNKWKLDKKFGFYVLFLYAIFLCFSVLI 595

  Fly   594 E 594
            |
Frog   596 E 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14743	NP_610408.2	Na_Ca_ex	77..220	CDD:279963	40/152 (26%)
CG14743	NP_610408.2	Na_Ca_ex	450..591	CDD:279963	33/141 (23%)
slc24a4	XP_002933272.2	2A1904	<91..596	CDD:273344	116/584 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910