Protein Alignment CG14744 and Slc24a3

DIOPT Version :9

• Sequence 1: NP_001097232.2
• Gene: CG14744 / 35858
• FlyBaseID: FBgn0033324
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_001343426.1
• Gene: Slc24a3 / 94249
• MGIID: 2137513
• Length: 645
• Species: Mus musculus
• Alignment Length: 622
• Identity: 126/622 - (20%)
• Similarity: 218/622 - (35%)
• Gaps: 199/622 - (31%)

  Fly    84 ICVAFL-WLMSFNIGTYFSPVLKIISLKLHMNEYLAGVTFLAFGNCSPEIIANLMPV---RADAP 144
            :|..:: :.::.....:|.|.|:.|..:||::|.:||.||:|.|:.:||:..:::.|   :.|..
Mouse   114 LCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVG 178

  Fly   145 IFTI---TVGNTLAII----LLSGGTVCFLRPFRMNGHSTLRDLLFLLLGVEVLRFVMIKEGAVT 202
            :.||   .|.|.|.||    |.:|..|.      ::....|||.::..|.|..| .|.|.:..|:
Mouse   179 VGTIVGSAVFNILCIIGVCGLFAGQVVA------LSSWCLLRDSIYYTLSVVAL-IVFIYDEKVS 236

  Fly   203 LGEGIVLFLIYVVYVAINIADLALLRYYIRKLRRELDYLEGLTP--------------------- 246
            ..|.:||.|:|::|:.|...:..:.:.:.|:.:...:.:.||..
Mouse   237 WWESLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKAN 301

  Fly   247 ------------------------------------PPITEINAKIRKLISWEE----------- 264
                                                ||.|.::...|.||:..:
Mouse   302 FHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNG 366

  Fly   265 QDDIGIKDTTKYRRSRDTG-----NHFSNMTSSGYFVTPIP-ERRSEHVDYELNRTALH------ 317
            :.::.||...|:.....||     :...|.|.....|.... |..:|:.|.|.|.....
Mouse   367 ESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDIVAETDNETENENEDNENNENDEEEEEDED 431

  Fly   318 DSENPKNLQLFTEFFQSLNPVDAEAWQLGGWSNRIYLIARCPLVFVLQLFIPVVDYEKIKHGWSK 382
            |.|.|     :|.|......::...|.. .|          ||.|||...:|
Mouse   432 DDEGP-----YTPFDPPSGKLETVKWAF-TW----------PLSFVLYFTVP------------- 467

  Fly   383 LLNCTQIVTNPFVVITLVHSGVSSVYKTWHITLDFSISMWSPCLTVPLAIVIFLHSRTDVPPSYH 447
              ||.:                                                       |.:.
Mouse   468 --NCNK-------------------------------------------------------PHWE 475

  Fly   448 HLFIILTFFSSMVTLWLAVTELEV--LSEIVGIVFNLSESFMAVTFEAVSNATPDIIANYQLALQ 510
            ..|:: ||.||  |||:|.....:  :..|:|....:.:..|.:||.|...:.||.:|:..:|.|
Mouse   476 KWFMV-TFASS--TLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQ 537

  Fly   511 GYGRMAFAAIIGGPVFAILVSMSLAFIFNHRVREVGANSWVYGDLGDNCYLFLVITIVTTMWWSV 575
            |.|.||.:..||..||.||:.:.|.:.......:.|:    |..|.....::.|..::.:::.:|
Mouse   538 GMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGS----YIRLNSRGLIYSVGLLLASVFVTV 598

  Fly   576 TFDFHAR-----RSAGVFLWLVYLQFLLYAVCVEWDV 607
             |..|..     :..|.....:|..||.:::..|::|
Mouse   599 -FGVHLNKWQLDKKLGCGCLFLYGVFLCFSIMTEFNV 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14744	NP_001097232.2	Na_Ca_ex	79..221	CDD:279963	44/147 (30%)
		Na_Ca_ex	450..601	CDD:279963	42/157 (27%)
Slc24a3	NP_001343426.1	Na_Ca_ex	<89..631	CDD:332332	124/617 (20%)
		Alpha-1	148..188		12/39 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..398		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..442		10/42 (24%)
		Alpha-2	520..551		12/30 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840