DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14744 and SLC24A1

DIOPT Version :9

Sequence 1:	NP_001097232.2	Gene:	CG14744 / 35858	FlyBaseID:	FBgn0033324	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	NP_004718.1	Gene:	SLC24A1 / 9187	HGNCID:	10975	Length:	1099	Species:	Homo sapiens

Alignment Length:	714	Identity:	136/714 - (19%)
Similarity:	232/714 - (32%)	Gaps:	268/714 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 LFMLLFAFICVAFLWLMSFNIGTYFSPVLKIISLKLHMNEYLAGVTFLAFGNCSPEIIANLMPV- 139
            :|.:::.|:.:|.:      ...||.|.|.:|:.||.::|.:||.||:|.|..:||:..:|:.|
Human   459 VFGMMYVFVALAIV------CDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVF 517

  Fly   140 --RADAPIFTITVGNTLAIILLSGGTVCFL---RPFRMNGHSTLRDLLFLLLGVEVLRFVMIKEG 199
              .::..|.|| ||:.:..||...|| |.|   ....:......||:.|.:|.: ::..:...:.
Human   518 ISHSNVGIGTI-VGSAVFNILFVIGT-CSLFSREILNLTWWPLFRDVSFYILDL-IMLILFFLDS 579

  Fly   200 AVTLGEGIVLFLIYVVYVAINIADLALLRYYIRKLRRELD--YLEGLTPPPITEINAKIRKLISW 262
            .:...|.::|.|.|..||            :..|..:.::  ..|.|:..|:    ||:..|...
Human   580 LIAWWESLLLLLAYAFYV------------FTMKWNKHIEVWVKEQLSRRPV----AKVMALEDL 628

  Fly   263 EEQDDIGI-----KDTTKY-------RRSRDTGNHFSNMTSSGY-----FVTPIPERR--SEHVD 308
            .:..|..|     :|..|.       |.|..|..|.|.:.|:.|     .:.|:.|.|  .|..:
Human   629 SKPGDGAIAVDELQDNKKLKLPSLLTRGSSSTSLHNSTIRSTIYQLMLHSLDPLREVRLAKEKEE 693

  Fly   309 YELNRTA----------LHDSENPKNLQLFT---------EFFQSLNP----------------- 337
            ..||:.|          ..:.|.|..|...|         :..|..||
Human   694 ESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMPG 758

  Fly   338 -------------------------------------------------------VDAEAWQLGG 347
                                                                   :.||..::.|
Human   759 EEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGDNEGEDEGEIHAEDGEMKG 823

  Fly   348 WSNRIYLIARCPLVFVLQLFIPVVDYEKI---KHGWSKLLNCTQIVTNPFVVITLVHSGVSS--- 406
            ....                   .:.:::   .||.:|  |..:.|.:         .|.|.
Human   824 NEGE-------------------TESQELSAENHGEAK--NDEKGVED---------GGGSDGGD 858

  Fly   407 --------------------------------------VYKTWHIT----------LDFSISMWS 423
                                                  :...|..|          |.....:|
Human   859 SEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEPLSLDWPETRQKQAIYLFLLPIVFPLW- 922

  Fly   424 PCLTVPLAIVIFLHSRTDVPPSYHHLFIILTFFSSMVTLWLAVTELEVL--SEIVGIVFNLSESF 486
              ||||           ||.......|.:.||..|:  :|:|:....::  :..||....:||..
Human   923 --LTVP-----------DVRRQESRKFFVFTFLGSI--MWIAMFSYLMVWWAHQVGETIGISEEI 972

  Fly   487 MAVTFEAVSNATPDIIANYQLALQGYGRMAFAAIIGGPVFAILVSMS---LAFIFNHRVREVGAN 548
            |.:|..|...:.||:|.:..:|.:|.|.||.::.:|..:|.|.|.:.   |.|...:.::.|..:
Human   973 MGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVS 1037

  Fly   549 SWVYGDLGDNC--------YLFLVITIVTTMWWSVTFDFHARRSAGVFLWLVYLQFLLYAVCVE 604
            |     .|..|        .||::.:|.:..|       ...:..|..::|:|..||:.:|.:|
Human  1038 S-----NGLFCAIVLLFLMLLFVISSIASCKW-------RMNKILGFTMFLLYFVFLIISVMLE 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14744	NP_001097232.2	Na_Ca_ex	79..221	CDD:279963	41/147 (28%)
CG14744	NP_001097232.2	Na_Ca_ex	450..601	CDD:279963	40/163 (25%)
SLC24A1	NP_004718.1	2A1904	1..1099	CDD:273344	136/714 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..150
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..199
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..304
		Alpha-1	494..534		15/40 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	690..901		21/240 (9%)
		Alpha-2	979..1010		10/30 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810