DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14744 and SLC8B1

DIOPT Version :9

Sequence 1:	NP_001097232.2	Gene:	CG14744 / 35858	FlyBaseID:	FBgn0033324	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	NP_001345274.1	Gene:	SLC8B1 / 80024	HGNCID:	26175	Length:	584	Species:	Homo sapiens

Alignment Length:	604	Identity:	168/604 - (27%)
Similarity:	266/604 - (44%)	Gaps:	94/604 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 MSCRAVMRLPYNYRCRMATQVSDCKRIINFFNYFRMMYCSID---IDDKATEVLFMLLFAFICVA 87
            :.||.|..|..:.||.......||.....:.:|...::|...   :....|..:..||:.|:
Human    51 VDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFL--- 112

  Fly    88 FLWLMSFNIGTYFSPVLKIISLKLHMNEYLAGVTFLAFGNCSPEIIANLM----PVRADAPIFTI 148
               ::......:|.|.|..||..|.::..:||||||||||.:|:|.:.|:    |..|...:..:
Human   113 ---ILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGAL 174

  Fly   149 TVGNTLAIILLSGGTVCFLRPFRMNGHSTLRDLLFLLLGVEVLRFVMIKEGAVTLGEGIVLFLIY 213
            .....|...:::|| :..|.||........||::|.::.| .|.|:|:..|.|||...:....:|
Human   175 FGAGVLVTTVVAGG-ITILHPFMAASRPFFRDIVFYMVAV-FLTFLMLFRGRVTLAWALGYLGLY 237

  Fly   214 VVYVAINIADLALLRYYIRKLRRELDYLEGLTPPPITEINAKIRKLISWEEQDDIGIKDTTKYRR 278
            |.||   :..:.....|.|:.|..|     ..|.|:|.      :::|..|:|.:. .:|..|
Human   238 VFYV---VTVILCTWIYQRQRRGSL-----FCPMPVTP------EILSDSEEDRVS-SNTNSY-- 285

  Fly   279 SRDTGNHFSNMTSSGYFVTPIPERRSEHVDYELNRTALHDSENPKNLQLFTEFFQSLNPVDAEAW 343
              |.|:.:..:    :|             |:.....:              ..::|||:|...|
Human   286 --DYGDEYRPL----FF-------------YQETTAQI--------------LVRALNPLDYMKW 317

  Fly   344 QLGGWSNRIYLIARCPLVFVLQLFIPVVDYEKIKHGWSKLLNCTQIVTNPFVVITLVHSGVSSVY 408
            :......:...:.:.|:.|:|.|.:||||.:|....|.:.|||..:|.:|.||:..:.||...||
Human   318 RRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVY 382

  Fly   409 KTWHITLDFSISMWSPCLT--VPLAIVIFLHSRTDVPPSYHHLFIILTFFSSMVTLWL--AVTEL 469
            :...:     :.:|...:.  ..||.|.|..:....||..|.||..|.|.:|  .||:  |.||:
Human   383 EIGGL-----VPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTS--ALWINAAATEV 440

  Fly   470 EVLSEIVGIVFNLSESFMAVTFEAVSNATPDIIANYQLALQGYGRMAFAAIIGGPVFAILVSMSL 534
            ..:...:|:||.||.:.:.:|..|..|:..|..:::.||.|||.||||:|..||.:|.|||.:.|
Human   441 VNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGL 505

  Fly   535 AFIF----NH---RVREVGANSWVY-GDLGDNCYLFLVITIVTTMWWSVTFD-FHARRSAGVFLW 590
            ..:.    :|   ::...|...||. |.||    |.||.::|     ||... |...|..|..|.
Human   506 GCLLQISRSHTEVKLEPDGLLVWVLAGALG----LSLVFSLV-----SVPLQCFQLSRVYGFCLL 561

  Fly   591 LVYLQFLLYAVCVEWDVVH 609
            |.||.||:.|:..|:.|:|
Human   562 LFYLNFLVVALLTEFGVIH 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14744	NP_001097232.2	Na_Ca_ex	79..221	CDD:279963	45/145 (31%)
CG14744	NP_001097232.2	Na_Ca_ex	450..601	CDD:279963	57/161 (35%)
SLC8B1	NP_001345274.1	Na_Ca_ex	63..584	CDD:332332	164/592 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147882
Domainoid	1	1.000	64	1.000	Domainoid score	I10105
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41602
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4029
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		otm40494
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940