Protein Alignment CG14744 and SLC24A3

DIOPT Version :10

• Sequence 1: NP_001097232.2
• Gene: CG14744 / 35858
• FlyBaseID: FBgn0033324
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_065740.2
• Gene: SLC24A3 / 57419
• HGNCID: 10977
• Length: 644
• Species: Homo sapiens
• Alignment Length: 625
• Identity: 125/625 - (20%)
• Similarity: 220/625 - (35%)
• Gaps: 197/625 - (31%)

  Fly    78 MLLFAFICVAFLWLMSFNIGTYFSPVLKIISLKLHMNEYLAGVTFLAFGNCSPEIIANLMPV--- 139
            ::|.....:...:.::.....:|.|.|:.|..:||::|.:||.||:|.|:.:||:..:::.|
Human   110 VVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFIT 174

  Fly   140 RADAPIFTI---TVGNTLAII----LLSGGTVCFLRPFRMNGHSTLRDLLFLLLGVEVLRFVMIK 197
            :.|..:.||   .|.|.|.||    |.:|..|.      ::....|||.::..|.|..| .|.|.
Human   175 KGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVA------LSSWCLLRDSIYYTLSVIAL-IVFIY 232

  Fly   198 EGAVTLGEGIVLFLIYVVYVAINIADLALLRYYIRKLRRELDYLEGLTP---------------- 246
            :..|:..|.:||.|:|::|:.|...:..:.:.:.|:.:...:.:.||..
Human   233 DEKVSWWESLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVL 297

  Fly   247 -----------------------------------------PPITEINAKIRKLISWEE------ 264
                                                     ||.|.::...|.||:..:
Human   298 LKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSR 362

  Fly   265 -----QDDIGIKDTTKYRRSRDTGNHFSNMTSSGYFVTPIPERRSEHVDYELNRTALHDSENPKN 324
                 :.::.||...|:.....||.  |:....|...|    ||.:.|....|.|...:.:|..:
Human   363 AYTNGESEVAIKIPIKHTVENGTGP--SSAPDRGVNGT----RRDDVVAEAGNETENENEDNEND 421

  Fly   325 LQ----------LFTEFFQSLNPVDAEAWQLGGWSNRIYLIARCPLVFVLQLFIPVVDYEKIKHG 379
            .:          .:|.|......::...|.. .|          ||.|||...:|
Human   422 EEEEEDEDDDEGPYTPFDTPSGKLETVKWAF-TW----------PLSFVLYFTVP---------- 465

  Fly   380 WSKLLNCTQIVTNPFVVITLVHSGVSSVYKTWHITLDFSISMWSPCLTVPLAIVIFLHSRTDVPP 444
                 ||.:                                                       |
Human   466 -----NCNK-------------------------------------------------------P 470

  Fly   445 SYHHLFIILTFFSSMVTLWLAVTELEV--LSEIVGIVFNLSESFMAVTFEAVSNATPDIIANYQL 507
            .:...|:: ||.||  |||:|.....:  :..|:|....:.:..|.:||.|...:.||.:|:..:
Human   471 RWEKWFMV-TFASS--TLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIV 532

  Fly   508 ALQGYGRMAFAAIIGGPVFAILVSMSLAFIFNHRVREVGANSWVYGDLGDNCYLFLVITIVTTMW 572
            |.||.|.||.:..||..||.||:.:.|.:.......:.|:    |..|.....::.|..::.:::
Human   533 ARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGS----YIRLNSRGLIYSVGLLLASVF 593

  Fly   573 WSVTFDFHAR-----RSAGVFLWLVYLQFLLYAVCVEWDV 607
            .:| |..|..     :..|....|:|..||.:::..|::|
Human   594 VTV-FGVHLNKWQLDKKLGCGCLLLYGVFLCFSIMTEFNV 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14744	NP_001097232.2	PLN03151	55..601	CDD:215604	123/617 (20%)
		Na_Ca_ex	450..601	CDD:426387	43/157 (27%)
SLC24A3	NP_065740.2	2A1904	<90..629	CDD:273344	123/620 (20%)
		Alpha-1	149..189		12/39 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	405..442		5/36 (14%)
		Alpha-2	518..549		12/30 (40%)