Protein Alignment CG14744 and SLC24A2

DIOPT Version :9

• Sequence 1: NP_001097232.2
• Gene: CG14744 / 35858
• FlyBaseID: FBgn0033324
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_001362779.1
• Gene: SLC24A2 / 25769
• HGNCID: 10976
• Length: 661
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 112/570 - (19%)
• Similarity: 225/570 - (39%)
• Gaps: 104/570 - (18%)

  Fly    79 LLFAFICVAFLWLMSFNIGTYFSPVLKIISLKLHMNEYLAGVTFLAFGNCSPEIIANLMPV---R 140
            :::.||.:|.:      ...:|.|.|.:|:.||.:::.:||.||:|.|..:||:..:|:.|   .
Human   142 MIYMFIALAIV------CDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAH 200

  Fly   141 ADAPIFTITVGNTLAIILLSGGTVCFLRP-FRMNGHSTLRDLLFLLLGVEVLRFVMIKEGAVTLG 204
            ::..|.||.......|:.:.|....|.|. ..:......||:.|.::.: ::..:...:..:...
Human   201 SNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDL-IMLIIFFLDNVIMWW 264

  Fly   205 EGIVL---FLIYVVYVAINIADLALLRYYIRKLRRELDYLEGLTPPPITEINAKIRKLISWEEQD 266
            |.::|   :..|||::..|:.....::..|.:     :.:..:|.|   |..||..   :..::|
Human   265 ESLLLLTAYFCYVVFMKFNVQVEKWVKQMINR-----NKVVKVTAP---EAQAKPS---AARDKD 318

  Fly   267 DIGIKDTTKYRRSRDTGNHFSNMTSSGYF------VTPIPERRSEHVDYELNRTALHDSENPKNL 325
            :..:....:.:|...:.:..:::..:..|      :.|:.|....:...:...|...:....:..
Human   319 EPTLPAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKA 383

  Fly   326 QLFTEFFQSLNPVDAEAWQLGGWSNRIYLIARCPLVFVLQLFIPVVDYEKIKHGWSKLLNCTQI- 389
            .:..:..:....||....| .|.:|.:                     |||     :|.|.|..
Human   384 SILHKIAKKKCHVDENERQ-NGAANHV---------------------EKI-----ELPNSTSTD 421

  Fly   390 --------VTNPFVVITLVHSGVSSVYKTWHITLDFSISMWSP---------CLTVPLAIVIFLH 437
                    .:.|.....|.|:...:..:|.....|..:|:..|         .:..|:...:::
Human   422 VEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWI- 485

  Fly   438 SRTDVPPSYHHLFIILTFFSSMVTLWLAVTELEVL--SEIVGIVFNLSESFMAVTFEAVSNATPD 500
            :..||.......|..:|||.|:.  |:||....::  :..||....:||..|.:|..|...:.||
Human   486 TLPDVRKPSSRKFFPITFFGSIT--WIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPD 548

  Fly   501 IIANYQLALQGYGRMAFAAIIGGPVFAILVSMSLAFIFN---HRVREVGANSWVYGDLGDNC--- 559
            :|.:..:|.:|.|.||.::.:|..:|.|.|.:.|.::..   ||.:.|..:|     .|..|
Human   549 LITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSS-----NGLFCAIV 608

  Fly   560 -----YLFLVITIVTTMWWSVTFDFHARRSAGVFLWLVYLQFLLYAVCVE 604
                 .||::::|....|       ...:..|..::.:|..||:.:|.:|
Human   609 LLFIMLLFVILSIALCKW-------RMNKILGFIMFGLYFVFLVVSVLLE 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14744	NP_001097232.2	Na_Ca_ex	79..221	CDD:279963	34/148 (23%)
		Na_Ca_ex	450..601	CDD:279963	42/163 (26%)
SLC24A2	NP_001362779.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	99..120
		2A1904	<115..661	CDD:273344	112/570 (20%)
		Alpha-1	174..214		13/39 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..336		5/32 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..439		11/68 (16%)
		Alpha-2	541..572		10/30 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810