DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14744 and SPAC3A12.06c

DIOPT Version :9

Sequence 1:	NP_001097232.2	Gene:	CG14744 / 35858	FlyBaseID:	FBgn0033324	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	NP_593332.1	Gene:	SPAC3A12.06c / 2543183	PomBaseID:	SPAC3A12.06c	Length:	743	Species:	Schizosaccharomyces pombe

Alignment Length:	733	Identity:	154/733 - (21%)
Similarity:	275/733 - (37%)	Gaps:	197/733 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 MSCRAVMRLPYNYRCRMATQVSDCK-RIINFFNYFRMMYCSIDIDDKATEVLFMLLFAFICVAFL 89
            ::|..:..:....:||.|.  :.|| ....||:|....:|:|:          .|.|..:.:...
pombe    65 LTCNDIKNITPANQCRFAK--AYCKGEASGFFDYVEFYFCTIN----------SLRFPVLSIIVG 117

  Fly    90 WL------MSFNIGTYFSPVLKIISLKLHMNEYLAGVTFLAFGNCSPEIIANLMPVRADAPIFTI 148
            ||      :..:...:||..|..||..|.:.:.:.||||||.||.||:|::....||.::....|
pombe   118 WLIFLFITIGISASDFFSTNLVTISWLLQLPDSVVGVTFLALGNGSPDILSTFAAVRVNSGGMAI 182

  Fly   149 --TVGNTLAIILLSGGTVCFLRPFRMNGHSTLRDLLFLLLGVEVLRFVMIKEGAVTLGEGIVLFL 211
              .:|:...|:.:..|:||.::||::.....|||:.||...:.::...::.:|::::.:.:|:.|
pombe   183 GELLGSAFFIVAIVAGSVCLIKPFKIPRRHFLRDVAFLTGTILLVIMFVLHDGSLSIWQSLVMIL 247

  Fly   212 IYVVYVAINIADLALLRYY-----IRKLRRELDYLEGLTP--PPITEINAKIRKLISWEEQDDIG 269
            .|::||        |..::     :..:..:.:||....|  .|:         |.|:::.|...
pombe   248 YYLLYV--------LFVFFSGSSGVSVVITDENYLPVSLPVYSPV---------LNSFDDSDSYS 295

  Fly   270 IKD-----------------TTK--YRRSRDTGNHFS-------------NMT--------SSGY 294
            ..|                 |.|  |....|..|.:|             |.|        |||.
pombe   296 STDSELSEEAFLLPAQASRKTQKIHYINDNDPSNSYSSYQHSHVHDFIHKNNTHSNRVLSQSSGP 360

  Fly   295 FVTPI---------------PERRS---------------EHVDYE---------------LNRT 314
            .|.|.               |..||               .|:.:.               :|..
pombe   361 IVRPSLLAALDFRSSNEEQHPGLRSLDPLNIQDGDLTMHPMHIRHSQSDFYPSGINTPVSGINYP 425

  Fly   315 ALHDSENPKNLQLFTEFFQSLNPVDAE-----------------AWQLGGWSNRIYLIARCPLVF 362
            .|..|.|.....|.:|.|:.....|.:                 .:....|..::..:...|.|.
pombe   426 NLGFSANNSVQSLVSEIFRHPTHTDEDFPLPSPSLSSLLFPTLRNFAKKSWYEKLMDVLAVPSVL 490

  Fly   363 VLQLFIPVVDYEKI----------------KHGWSKLLNCTQIVTNPFVVITLVHSGVSSVYKTW 411
            :..|.:||....::                |..||:.|...|.|..||..:|...:|.:.:| .:
pombe   491 IFTLALPVYQCPRLAVDPIYHMDVSNCNPSKPTWSRKLRLLQCVFVPFAFVTFSITGGNRLY-IY 554

  Fly   412 HITLDFSISMWSPCLTVPLAIVIFLHSRTDVPPSYHHLFIILTFFSSMVTLWLAVTELEVLS--E 474
            ..:..|||.    |:|     .::.::..:.||.:......:.|...::  |::....||:.  .
pombe   555 AASSVFSIL----CIT-----ALYYYTDEEKPPKFLPWVSFIGFVLGII--WISTIANEVVGILR 608

  Fly   475 IVGIVFNLSESFMAVTFEAVSNATPDIIANYQLALQGYGRMAFAAIIGGPVFAILVSMSLAFIF- 538
            .:|::|||:||.:.:|..|..|:..|:||:..:|..|:..||...:.|||...||:.:.::..:
pombe   609 ALGVIFNLNESILGLTVFAAGNSLSDLIADIMIARSGFPEMAMGGVFGGPTLNILIGIGISSFYS 673

  Fly   539 ------NHRVREVGANSWVYGDLGDNCYLFLVITIVTTMWWSVTFDFHARRSAGVFLWLVYLQFL 597
                  |..|.|:..:..:.......|.|.|:|.:....       |...|..|:.|      |:
pombe   674 SISNHGNDSVIEIPHSLSITAYFLLACLLLLLIYVPLNR-------FRVNRVLGLLL------FI 725

  Fly   598 LYAVCVEWDVVHEFSRDQ 615
            ||.|....::|.|..:|:
pombe   726 LYIVGTSTNIVVELLKDK 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14744	NP_001097232.2	Na_Ca_ex	79..221	CDD:279963	42/149 (28%)
CG14744	NP_001097232.2	Na_Ca_ex	450..601	CDD:279963	39/159 (25%)
SPAC3A12.06c	NP_593332.1	PLN03151	76..729	CDD:215604	149/706 (21%)
		Na_Ca_ex	118..258	CDD:279963	41/147 (28%)
		Na_Ca_ex	584..729	CDD:279963	39/159 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	73	1.000	Domainoid score	I2545
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I1261
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	1	1.000	-	-		X612
TreeFam	1	0.960	-	-
	11	10.850