Protein Alignment CG14744 and Slc24a4

DIOPT Version :9

• Sequence 1: NP_001097232.2
• Gene: CG14744 / 35858
• FlyBaseID: FBgn0033324
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_742164.2
• Gene: Slc24a4 / 238384
• MGIID: 2447362
• Length: 622
• Species: Mus musculus
• Alignment Length: 592
• Identity: 133/592 - (22%)
• Similarity: 230/592 - (38%)
• Gaps: 154/592 - (26%)

  Fly    80 LFAFICVAFLWLMSFNIGTYFSPVLKIISLKLHMNEYLAGVTFLAFGNCSPEIIANLMPV---RA 141
            |:.|..:|.:      ...:|.|.|:.|..|||::|.:||.||:|.|:.:||:.|:::.|   ..
Mouse   108 LYMFYALAIV------CDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHG 166

  Fly   142 DAPIFTI---TVGNTLAII----LLSGGTVCFLRPFRMNGHSTLRDLLFLLLGVEVLRFVMIKEG 199
            |..:.||   .|.|.|.||    |.:|..|      |:...:..||.::..|.|.|| ...|.:.
Mouse   167 DVGVGTIVGSAVFNILCIIGVCGLFAGQVV------RLTWWAVCRDSVYYTLSVIVL-IAFIYDE 224

  Fly   200 AVTLGEGIVLFLIYVVYVAINIADLALLRYYIRK---------LRREL----------------- 238
            .:...||:||.::||.|:.|...::.:..::..|         :..||
Mouse   225 EIVWWEGLVLIILYVFYILIMKYNMKMQTFFTTKQKSIANGNPVSNELEDGNDLYDGSYDDPSVP 289

  Fly   239 -------------------DYLEGLTPPPITEINAKIRKLISWEEQDDIGIKDTTKYR-RSRDTG 283
                               |.:...:||..|...|.:|.:|:    :..|.:  |:.| .||...
Mouse   290 LLGQVKEKPPYGKTPVVMVDEILSSSPPKFTFPEAGLRIMIT----NKFGPR--TRLRMASRIII 348

  Fly   284 NHFSNMTSSGYFVTPIPERRSEHVDYELNRTALHDSENPKNLQLFTEFFQSLNPVDAEAWQLGGW 348
            |....:.:|...|...|.:...|.:.|.....:   |||::.|...|......|...|...:
Mouse   349 NERQRLINSANGVNSKPLQNGRHENMENGNVPV---ENPEDPQQGQEQQPPPQPPPPEPESV--- 407

  Fly   349 SNRIYLIARCPLVFVLQLFIPVVDYEKIKHGWSKLLNCTQIVTNPFVVITLVHSGVSSVYKTWHI 413
                      ..||:....:|....:|.|  |        :.|.|.:.:.
Mouse   408 ----------ETVFLSPFSMPEAKGDKAK--W--------VFTWPLIFLL--------------- 437

  Fly   414 TLDFSISMWSPCLTVPLAIVIFLHSRTDVPPSYHHLFIILTFFSSMVTLWLAV-TELEV-LSEIV 476
                       |:|:|          ....|.:...|:: ||.::  |||:|| :.|.| |..|:
Mouse   438 -----------CVTIP----------NCSKPRWEKFFMV-TFITA--TLWIAVFSYLMVWLVTII 478

  Fly   477 GIVFNLSESFMAVTFEAVSNATPDIIANYQLALQGYGRMAFAAIIGGPVFAILVSMSL-----AF 536
            |....:.:..|.:||.|...:.||.:|:..:|.||.|.||.:..||..||.|||.:.:     ..
Mouse   479 GYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTM 543

  Fly   537 IFNH-RVREVGANSWVYGDLGDNCYLFLVITIVTTMWWSVTFDFHARRSAGVFLWLVYLQFLLYA 600
            :.|: ...::.:...||.      .:.|:.::..|:.......:...|..|:::.::|..||.::
Mouse   544 VINYGSTVKINSRGLVYS------VVLLLGSVALTVLGIHLNKWRLDRKLGIYVLVLYAVFLCFS 602

  Fly   601 VCVEWDV 607
            :.:|::|
Mouse   603 IMIEFNV 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14744	NP_001097232.2	Na_Ca_ex	79..221	CDD:279963	48/150 (32%)
		Na_Ca_ex	450..601	CDD:279963	43/158 (27%)
Slc24a4	NP_742164.2	Na_Ca_ex	<80..606	CDD:332332	131/587 (22%)
		Alpha-1	139..179		13/39 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	358..408		11/65 (17%)
		Alpha-2	495..526		12/30 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840