Protein Alignment CG14744 and ncx-8

DIOPT Version :9

• Sequence 1: NP_001097232.2
• Gene: CG14744 / 35858
• FlyBaseID: FBgn0033324
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_504341.1
• Gene: ncx-8 / 182575
• WormBaseID: WBGene00003573
• Length: 703
• Species: Caenorhabditis elegans
• Alignment Length: 672
• Identity: 154/672 - (22%)
• Similarity: 270/672 - (40%)
• Gaps: 173/672 - (25%)

  Fly    55 FFNYFRMMYCSIDIDDKATEV---LFMLLFAFICVAFLWLMSFNIGTYFSPVLKIISLKLHMNEY 116
            :..:...:.|..:|..:...:   :..|:|.|:      :||.....:|.|.:..|...|.|:|.
 Worm    85 YLTWSHYVKCQYNIGARVVLIIVGIIYLIFLFV------VMSTIADDFFCPSISGIVTHLKMSES 143

  Fly   117 LAGVTFLAFGNCSPEIIANLMPVRA--------------DAPIFTITVGNTLAIILLSGGTVCFL 167
            :||||||||||.:|::..::..|.:              ...||..||  .||||:       |.
 Worm   144 IAGVTFLAFGNGAPDVFGSISSVLSTPKPKAALALGDLFGTSIFVTTV--VLAIII-------FT 199

  Fly   168 RPFRMNGHSTLRDLLFLLLGVEVLRFVMIKEGAVTLGEGIVLFLIYVVYVAINIADLALLRYYIR 232
            :.|::....|||||:|.::.:..:.|..:|...:.:........||.||:      |.::.:.|.
 Worm   200 KSFKVAIIPTLRDLIFYMITLAFITFCFLKFDKIEVWMPATFLGIYAVYL------LTVIAFSIY 258

  Fly   233 KLRRELDYLEGLTPPPITEINAKIRKLISWEEQDDIGI-------------KDTTKYRRSRDTGN 284
            :.||:               |.|.:|.:..|:.|:..|             :...|...|.....
 Worm   259 RTRRK---------------NLKKKKQLESEKDDESAISRPESVASNMPICEKLEKKTESMSVST 308

  Fly   285 HFSNMTSSGYFVTP-----------------IPERRSEHVDYE--------------LNRTALHD 318
            .|..|.....|:..                 :.|..||.:|.:              .|:|...|
 Worm   309 LFHVMVGLSRFMKKLNRTNKIQSIENKKQGFVNEGFSESLDADELTLKRNRMISLIFRNKTLDTD 373

  Fly   319 SENPKNLQ--------------------LFTEFFQ-SLNPVDAEAWQLGGWSNRIYLIARCPLVF 362
            .|:.|.|.                    :||...| ||...:.|..:|..|.:|.::|   .|::
 Worm   374 LESMKTLDEMESSDDEGREEEFAYAHHTVFTSHDQMSLAATEFEFRELTTWRSRDWII---DLLY 435

  Fly   363 VLQLFIPVVDYEKIKHGWSKLLNCTQIVTNPFVVIT-------------LVHSGVSSVYKTWHIT 414
            .|:.:....::.:: :.:.|::...:|:.:.|:.:|             |:|...|..:..:.|.
 Worm   436 HLKPWPSREEFSEM-NIFVKIIMIIRIIPSFFMKMTIPSNEMSWCKPLFLLHCFASIQFALFSIQ 499

  Fly   415 L------DFSISMWSPCL----TVPLAIVIFLHSRTDVPPSYH-HLFIILTFFSSMVTLWLAVTE 468
            :      |.|..:|...|    |:.|..:.||....::  .|| .::..|.|..|:.  |:..|.
 Worm   500 IINLKPFDGSPGLWLYGLAFSATIALLALCFLPLNKEL--KYHKEVYSYLGFLMSIA--WIYATA 560

  Fly   469 LEVLS--EIVGIVFNLSESFMAVTFEAVSNATPDIIANYQLALQGYGRMAFAAIIGGPVFAILVS 531
            .|::|  .:||:|..||:..:.:|..:.|:...||:|:..:..|||.:||.||.||||:|.:|:.
 Worm   561 NEIISVMTMVGVVTGLSQELLGLTVMSWSDCIGDIVADIAVIKQGYPKMAMAAAIGGPLFNLLIG 625

  Fly   532 MSLAF-IFNHRVREVGANSWVYGDLGDN-----CYLFLVITIVTTMWWSVTFDFHARRSAGVFLW 590
            ..|.| |.:.:.:::        ||..|     ..|||.|::|||........|..|....|.|.
 Worm   626 FGLPFTIASAQGKQI--------DLIINPVYRILLLFLGISLVTTFVALFIERFTVRWPHAVALI 682

  Fly   591 LVYLQFLLYAVC------VEWD 606
            .:::.|::: ||      :||:
 Worm   683 FIFINFVIF-VCLAEFHVLEWN 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14744	NP_001097232.2	Na_Ca_ex	79..221	CDD:279963	45/155 (29%)
		Na_Ca_ex	450..601	CDD:279963	48/158 (30%)
ncx-8	NP_504341.1	PLN03151	61..628	CDD:215604	132/586 (23%)
		Na_Ca_ex	107..253	CDD:279963	46/166 (28%)
		Na_Ca_ex	544..681	CDD:279963	46/146 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165697
Domainoid	1	1.000	75	1.000	Domainoid score	I5893
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41602
Inparanoid	1	1.050	162	1.000	Inparanoid score	I2840
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		mtm4752
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750