DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14744 and ncx-6

DIOPT Version :9

Sequence 1:	NP_001097232.2	Gene:	CG14744 / 35858	FlyBaseID:	FBgn0033324	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	NP_499146.2	Gene:	ncx-6 / 182354	WormBaseID:	WBGene00003571	Length:	590	Species:	Caenorhabditis elegans

Alignment Length:	569	Identity:	136/569 - (23%)
Similarity:	223/569 - (39%)	Gaps:	134/569 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 TEVLFMLLFAFICVAFLWLMSFNIGTYFSPVLKIISLKLHMNEYLAGVTFLAFGNCSPEIIANLM 137
            |.|::||      |.|: ::|.....:|||.:..|...|.::|.:|||||:||||.:|::...:.
Worm   102 TGVIYML------VLFI-MVSSAADDFFSPSISSIVAHLRISESVAGVTFMAFGNGAPDVFGAIA 159

  Fly   138 PV------RAD--------APIFTITVGNTLAIILLSGGTVCFLRPFRMNGHSTLRDLLFLLLGV 188
            .|      :||        |.:|..|:  .||:.:       |.|||:....|::||:.|.|:.:
Worm   160 SVLSSPTPKADLALGELFGAGLFVTTM--VLAVTI-------FTRPFKAEVFSSIRDIAFYLVAL 215

  Fly   189 EVLRFVMIKEGAVTLGEGIVLFLIYVVYVAINIADLALLRYYIRKLRRELDYLEGLTPPPITEIN 253
            ..|.|..:....|.:...|....:|::||...|.. .:|....:|...::|             .
Worm   216 AFLAFCFVYYDHVEIWMPITFLGVYLIYVCTVILS-QILHNRHKKDEEKVD-------------E 266

  Fly   254 AKIRKLISWEEQDDIGIKDTTKYRRSRDTGNHFSNMTSSGYFVTPIPERRSEHVDYEL------- 311
            .|.....|.|:.|||.:                    |.|:.|....|......:.|.
Worm   267 VKTVDTDSLEDDDDIYV--------------------SHGHHVLHAHEVMKMEAEIEAVEPLKTW 311

  Fly   312 -NRTALHDSENPKNLQLFTEFFQSLNP-VDAEAWQLGGWSNRIYLIARCPLVFVLQLFIPVVDYE 374
             .|..:||            |.:.|.| ...:.|.......::..:......|:.:|.||
Worm   312 SFRGVVHD------------FKEHLKPWPSMDEWDEMNIFQKVIAVLNTIPNFLFKLTIP----- 359

  Fly   375 KIKHGWSK---LLNCTQIVTNPFVVITLVHSGVSSVYKT---WHITLDFSISMWSPCLTVPL-AI 432
            ..:..|||   ||.|  ::...|::..:....:|....:   |         |:...|:|.| |.
Worm   360 HSEQPWSKPITLLQC--LICPVFLLFCIQVCSISPFPNSPGLW---------MYGLILSVLLTAA 413

  Fly   433 VIFLHSRTDVPPSYHHLFIILTFFSSMVTLWLAVTELEVLSEIVGIVFNLSESFMAVTFEAVSNA 497
            |:|.......||.|..|.....|..|:..::|..:|:..:..::|:|..:|...:.:|..|.||:
Worm   414 VLFFTELHKEPPFYKSLISYAGFLMSIAWIYLISSEVVNVVTMLGVVSRVSHEVLGLTILAWSNS 478

  Fly   498 TPDIIANYQLALQGYGRMAFAAIIGGPVFAILVSMSLAF------------IFNHRVREVGANSW 550
            ..|:||:..:|.|||.|||.||.|||.:|.:|:...|.|            |.|...|.:
Worm   479 IGDLIADVSVAKQGYPRMAMAAAIGGQLFNLLIGFGLPFTIAKIQGKSISMIINPTYRLL----- 538

  Fly   551 VYGDLGDNCYLFLVITIVTTMWWSVTFDFHARRSAGVFLWLVYLQFLLY 599
                     .|||.|:::.|:.......:..||.....|..:|:.|.::
Worm   539 ---------MLFLAISLIFTLIAMFAQKYFLRRIHSYSLVFIYISFFVF 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14744	NP_001097232.2	Na_Ca_ex	79..221	CDD:279963	44/155 (28%)
CG14744	NP_001097232.2	Na_Ca_ex	450..601	CDD:279963	43/162 (27%)
ncx-6	NP_499146.2	Na_Ca_ex	105..249	CDD:279963	45/159 (28%)
ncx-6	NP_499146.2	Na_Ca_ex	431..579	CDD:279963	43/162 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165706
Domainoid	1	1.000	75	1.000	Domainoid score	I5893
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41602
Inparanoid	1	1.050	162	1.000	Inparanoid score	I2840
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		mtm4752
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750