DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12376 and SLC24A1

DIOPT Version :9

Sequence 1:NP_610405.3 Gene:CG12376 / 35857 FlyBaseID:FBgn0033323 Length:617 Species:Drosophila melanogaster
Sequence 2:NP_004718.1 Gene:SLC24A1 / 9187 HGNCID:10975 Length:1099 Species:Homo sapiens


Alignment Length:728 Identity:135/728 - (18%)
Similarity:243/728 - (33%) Gaps:265/728 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 DLNCVNEFEQVIFLALFMGLCYEILVLLIHVCNKYYSPALKAVSRFLCMNEHVAGVTLLAFGNSS 126
            ||..|.|..|...:....|:.| :.|.|..||::|:.|||..::..|.::|.|||.|.:|.|.|:
Human   443 DLFSVEERRQGWVVLHVFGMMY-VFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSA 506

  Fly   127 ADLFSNLASV---NANVPVFANSLAAALF-VSMVSGGLICYTSP-FKMNAYESVRDILFLIFG-S 185
            .:||::|..|   ::||.: ...:.:|:| :..|.|....::.. ..:..:...||:.|.|.. .
Human   507 PELFTSLIGVFISHSNVGI-GTIVGSAVFNILFVIGTCSLFSREILNLTWWPLFRDVSFYILDLI 570

  Fly   186 MLLQYFLASSAHVPETSFIVMFLVYIFYILV----NVVDVY----LIRRALKTTNAQID------ 236
            ||:.:||.|.....|:  :::.|.|.||:..    ..::|:    |.||.:....|..|      
Human   571 MLILFFLDSLIAWWES--LLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKPGD 633

  Fly   237 -ALLVGEMTPEKRKRLSELERNQAIYTRDMEVEIFERTNSGPNINKIRYTTLRMGRSTRISLDRK 300
             |:.|.|:...|:.:|..|      .||            |.:...:..:|:   |||       
Human   634 GAIAVDELQDNKKLKLPSL------LTR------------GSSSTSLHNSTI---RST------- 670

  Fly   301 ATRMVLHNRALGRNWGLFKDLFIALRPINCEKWRKGNIIKRAFML---------------TKIPA 350
            ..:::||:             ...||.:...|.::...:.:....               .|:||
Human   671 IYQLMLHS-------------LDPLREVRLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKLPA 722

  Fly   351 VIICCIYIPLV------------------------------------------------------ 361
            |.:....:|.:                                                      
Human   723 VTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETET 787

  Fly   362 ------------------------------DYEL--------------DKHGWNKLLNCIQVMLN 382
                                          |.|:              :.||..|         |
Human   788 QGKGEECEDENEAEGKGDNEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAK---------N 843

  Fly   383 PAMSI---------------------------------MAIKALLSSRGN----SL-WYVAMGEE 409
            ....:                                 ...:.....:||    || |.....::
Human   844 DEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEPLSLDWPETRQKQ 908

  Fly   410 AIYAMYSLPITVPIAVFMFIQSRTDVPPFYHSVFTVMNLTGSMFMIFICATEIDKVLEVIGHILK 474
            ||| ::.|||..|:.:.:....|.:...|:  |||.:   ||:..|.:.:..:......:|..:.
Human   909 AIY-LFLLPIVFPLWLTVPDVRRQESRKFF--VFTFL---GSIMWIAMFSYLMVWWAHQVGETIG 967

  Fly   475 VEDDFMGATVKACTGSLGPLIANVAMALHGYPRMAYASAIGGPFFTVVMSASTVMHVKNLFGLPV 539
            :.::.||.|:.|...|:..||.:|.:|..|...||.:|::|...|.:.:            ||||
Human   968 ISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITV------------GLPV 1020

  Fly   540 -----SEANQTGNYGLNAFIFLNLGVFSTLLWSTTLGFFARRSV-----------GIFSIVFYCI 588
                 |..|     ||......:.|:|..::....:..|...|:           |....:.|.:
Human  1021 PWLLFSLIN-----GLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFV 1080

  Fly   589 YLLFAILIHRKVI 601
            :|:.::::..::|
Human  1081 FLIISVMLEDRII 1093

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12376NP_610405.3 PLN03151 33..592 CDD:215604 134/717 (19%)
Na_Ca_ex 85..219 CDD:279963 41/143 (29%)
Na_Ca_ex 448..595 CDD:279963 34/162 (21%)
SLC24A1NP_004718.1 2A1904 1..1099 CDD:273344 135/728 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 123..150
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..199
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 284..304
Alpha-1 494..534 14/40 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 690..901 15/219 (7%)
Alpha-2 979..1010 11/30 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0530
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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