Protein Alignment CG12376 and ECM27

DIOPT Version :10

• Sequence 1: NP_610405.3
• Gene: CG12376 / 35857
• FlyBaseID: FBgn0033323
• Length: 617
• Species: Drosophila melanogaster
• Sequence 2: NP_012640.4
• Gene: ECM27 / 853570
• SGDID: S000003867
• Length: 725
• Species: Saccharomyces cerevisiae
• Alignment Length: 695
• Identity: 121/695 - (17%)
• Similarity: 241/695 - (34%)
• Gaps: 229/695 - (32%)

  Fly    85 ILVLLIHVCNKYYSPALKAVSRFLCMN-EHVAG-------------------------VTLLAFG 123
            |..:|:.:|          .|.|||.| .|::.                         ..||::.
Yeast    33 IAFVLLGIC----------ASDFLCPNVAHISDPNSLRSNGSLVSKTASHASHTGALMAVLLSWC 87

  Fly   124 NSSADLFSNL----------ASVNANVPVFANSLAAALFVSMVSGGLICYTSP-----FKMNAYE 173
            |||.||||||          .|.:.::.:.....|..:.:.:|.|.:....|.     .::....
Yeast    88 NSSPDLFSNLMSWATSTRETRSTSVSLSIGEVLGACGIILCIVEGSIFIIMSRTHIEISQIQKLS 152

  Fly   174 SVRDILFLIFGSMLLQYFLASSAHVPETSFIVMFLVYIFYILVNVVDVYLIRRALKTTNAQI--- 235
            .:||:||.: .:|.:..:::....|...:.::|..:|.||::|.:  .:.:..:.:|.:...
Yeast   153 IMRDLLFSL-AAMCVMSYVSLMNQVTVLNCLLMAFLYAFYLVVKL--TFKLNHSAETPDETAADT 214

  Fly   236 ------------DALLVGEMTPE---------------KRKRLSELERNQAI-YTRDMEVEIFER 272
                        |:|:...:.|.               |...||.::.|..: ...:..:|..:.
Yeast   215 SLRENSVSPFLDDSLMASGLLPPIQPGFDISNSITHGIKPSLLSAMDFNSFLSMLENSSLEEDDS 279

  Fly   273 TNSGPNINKIRYTTLRMGRSTRISLDRKAT----------------------------------- 302
            .|....:|.:|..|.....|...::..:||
Yeast   280 RNEMAELNTLRSMTPGQHWSASATVAGEATSAGRPFSEPTNAFTEYRDSERAINSSPAVFAPYRD 344

  Fly   303 ---------RMVLHNRALG------------RNWGLFKDLFIALRPINCEKWRKGNIIKRAFMLT 346
                     :::|.....|            |:.|....:||.    :...:.:.:|....|.:.
Yeast   345 NPDDEESQEQVLLETTTHGHFGAQEMRRFSKRSLGWIIKIFIP----HLSNFSQKSISDAIFSII 405

  Fly   347 KIPAVIICCIYIP-----LVDYE--LDKHGWNKLLNCIQVMLNPAMSIMAIKALLSSRGNSLWYV 404
            .:|..||..:..|     ::.|:  |:::.    |..:.::|....||.|...|.|.....|.|
Yeast   406 TVPFFIIFKLSCPQPPSDILSYDPTLNRYS----LTTLPIILLFIQSITAPFLLCSILSVLLTY- 465

  Fly   405 AMGEEAIYAMYSLPITVPIAVFMFIQS-RTDVPPFYHSVFTVM------------------NLTG 450
            .:|    |.:|..|:.:.:|:.:.:.: .|.|.  .|:.||:.                  .|..
Yeast   466 HLG----YLVYLFPLILAMALILLLTAFITKVN--LHNKFTLSLDSSNILQEKLQKRKLLERLNT 524

  Fly   451 SMFMIFIC-------------ATEIDKVLEVIGHILKVEDDFMGATVKACTGSLGPLIANVAMA- 501
            |:.:||:.             |..:.:::|:...||.:....:|.|:.|...|:|.||:|::|.
Yeast   525 SIQIIFLAIGIINIIIWISLLANSLIEMMEIYQKILGLSKAILGLTIFAWGNSVGDLISNISMCR 589

  Fly   502 -----LHGYPRMAYASAIGGPFFTVVMSASTVMHVKNLFGLPVSEANQTGNYGLNAFIFLNLGVF 561
                 .|...|:..|:.     |.::..||.      |.|:.::.....|..||.:.:|  :|.|
Yeast   590 LYKTQTHYQDRVRLATK-----FFMISCASC------LGGVMLNSMGGIGFSGLVSMLF--IGAF 641

  Fly   562 STLLWSTTLGFFARR----------SVGIFSIVFYCIYLLFAILI 596
            :...|     :|.|:          :...:..:..|::::..|::
Yeast   642 NDNEW-----WFLRKVKLQETSQLDNTLNYKFIVSCVFIILQIIL 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	120/689 (17%)
ECM27	NP_012640.4	Na_Ca_ex	27..196	CDD:426387	36/173 (21%)
		PLN03151	<544..637	CDD:215604	24/103 (23%)