DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12376 and YDL206W

DIOPT Version :9

Sequence 1:	NP_610405.3	Gene:	CG12376 / 35857	FlyBaseID:	FBgn0033323	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_010075.1	Gene:	YDL206W / 851321	SGDID:	S000002365	Length:	762	Species:	Saccharomyces cerevisiae

Alignment Length:	785	Identity:	144/785 - (18%)
Similarity:	256/785 - (32%)	Gaps:	310/785 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 VNEF--EQVIFLALFMGLCYEILVLLIHVCNKYYSPALKAV-SRFLCMNEHVAGVTLLAFGNSSA 127
            ::||  ..|:.:.     |:.:|.::...|   .:|:|..: |....:::.|:|:||||.||:..
Yeast    31 ISEFYLHSVVLIE-----CFSLLGVVTSDC---LTPSLSYISSNIFHISDRVSGMTLLALGNALP 87

  Fly   128 DLFSNLASVNANVPVFA-NSLAAALF--VSMVSGGLIC--------------YT-SPFKMN-AYE 173
            |:.|...|:.:.|...| ..|...:|  :::|.|.:.|              || ..|..| :|:
Yeast    88 DITSTYQSMKSGVTSLAIGELFGGIFFLLTVVIGLMGCVATIQFQHDKSIETYTEESFDQNLSYD 152

  Fly   174 SVRDILFL-IFGSMLL--QYFLASSAHVPETSFIVMFLVYIFYILVNVVDVYLI----------- 224
            ....||.: ||..|||  ..||| ...:.....|||.|.|.      ...||||
Yeast   153 RSNYILDVGIFTFMLLVSGTFLA-DGRLYFWECIVMVLTYC------CCAVYLIKSYKYPCEIND 210

  Fly   225 ----------------------RRALKTT-----------------NAQIDALLVGEMTPEK--R 248
                                  |..|.||                 :.|||......:.|.:  .
Yeast   211 ALEREVEIKKTVLANNHITVPNRFTLTTTSDITSTDDGIRYVRPLGDTQIDEDNAISLDPTRLPS 275

  Fly   249 KRLSELER-NQAI-------------YTR------------DMEVEIFERTN------------- 274
            |.|..:.| ||.|             |.|            |: :.|:|:.|
Yeast   276 KSLDNISRFNQGIPERRDLIRRRIRGYLRSHYHGWVRMTLQDL-LNIWEKQNLFNNTVKSLSLPS 339

  Fly   275 --------------SGPNINK----------IRYTTLRMG------------------------- 290
                          ..|.|.|          .:|.:||.|
Yeast   340 DDTHLFTKASLDEEGRPLIRKRMNSLQPKDFYKYLSLRNGENSNALDTAISAPQNEYQTYYNEPT 404

  Fly   291 -------------------------RSTRISLDRKATRM-------------------------V 305
                                     ||..|.|:.:|||.                         :
Yeast   405 SLFLTVPQKKTSKKSLSCDRIPNLVRSNNIILNDEATRTQESTNALNSISDVIDNSLLQYERDDI 469

  Fly   306 LHNRALG-------RNWGLFKDLFIALRPINCEKWRKGNIIKRAFMLTKIPAVIICCIYIP---- 359
            :.:|.|.       ..|..|: |:..|..::.|.    ...:...:|...|..||..:.||
Yeast   470 ILDRTLSLCSTKSRTAWHSFQ-LYNYLTDVSLEI----GFFEFLSLLVTTPVSIILYLSIPSEIS 529

  Fly   360 LVDYELDKHGWNKLLNCIQVMLNPAMSIMAIKALLSSRGNSLWYVAMGEEAIYAMYSLPITVPIA 424
            ..|::|..    ..|..||::.:|    :.:..|:::.              ::.:.|.:::.||
Yeast   530 QTDHDLPL----SYLQNIQLIASP----IILNQLITNN--------------FSFWLLILSLVIA 572

  Fly   425 VFMFIQSRTDVPPFYHS--VFTVMNLTGSMFMIFICATEIDKVLEV-IGH---ILKVEDDFMGAT 483
            :.::.::|| :|..::|  :|||     :..:...|.::...::.| :.|   :..:.:..:|.|
Yeast   573 ILLYFKTRT-IPNKFNSDIIFTV-----AFLLSLACLSKAVHIIVVTLTHWINVFNISETILGLT 631

  Fly   484 VKACTGSLGPLIANVAMALHGYPRMAYASAIGGPFFTVVMSASTVMHVKNLFGLPVSEANQTGNY 548
            :.....|:|.|::|:.....|...:|..:..|.|....:...       ...|:.:...::||..
Yeast   632 IFTWGNSIGDLVSNITFVKIGVLEIAIGACFGSPLLYFLFGV-------GFDGIMIMLGDKTGKI 689

  Fly   549 --GLNAFIF---LNLGVFSTLLWSTTLGFFARRSVGIFSIVFYCIYLLFAILIHRKVIHSFSVDL 608
              |.::.|.   ::..|...|:         ...|||.     ..:|:|.:||   .::.:.:|.
Yeast   690 VSGRDSNILMHHIDFKVDKNLI---------NTGVGIL-----IAFLIFTVLI---PLNDWKIDK 737

  Fly   609 PVKAA 613
            .:..|
Yeast   738 KISIA 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	139/762 (18%)
		Na_Ca_ex	85..219	CDD:279963	43/156 (28%)
		Na_Ca_ex	448..595	CDD:279963	25/155 (16%)
YDL206W	NP_010075.1	ECM27	28..>223	CDD:223604	51/206 (25%)
YDL206W	NP_010075.1	ECM27	<543..757	CDD:223604	43/248 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344055
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	1	1.000	-	-		X612
TreeFam	0	0.000	Not matched by this tool.
	9	8.770