DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12376 and AT5G17850

DIOPT Version :9

Sequence 1:	NP_610405.3	Gene:	CG12376 / 35857	FlyBaseID:	FBgn0033323	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_001318589.1	Gene:	AT5G17850 / 831653	AraportID:	AT5G17850	Length:	559	Species:	Arabidopsis thaliana

Alignment Length:	633	Identity:	151/633 - (23%)
Similarity:	239/633 - (37%)	Gaps:	162/633 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CYAANTF-PFEERCAFVASAKDCNRSTNVLPYMRIMACDLNCVNEFEQVIFLALFMGLCYEILV- 87
            |.|...| .::.:||::.|...| .|.....|:..:.|:      ||....|..|:...:.:|:
plant    46 CSALKHFHDYKSKCAYLKSIDPC-ASQGFFDYLSFLYCN------FEGFPILGQFLLFLWLLLLF 103

  Fly    88 -LLIHVCNKYYSPALKAVSRFLCMNEHVAGVTLLAFGNSSADLFSNLAS----------VNANVP 141
             ||.|..::|:..:|:::|:.|.::..|||||||:.||.:.|||::|.|          |..|..
plant   104 YLLGHTASEYFCSSLESLSKLLNLSPTVAGVTLLSLGNGAPDLFASLVSFMGESKGTYDVGLNTV 168

  Fly   142 VFANSLAAALFVSMVSGGLICYTSPFKMNAYESVRDILFL--IFGSMLLQYFLASSAHVPETSFI 204
            |..:.....:.|.::|..|  :....::.....:|||.|.  ..||:.|..............|.
plant   169 VGGSGFVTCVVVGIISISL--HKRRVRIERAAFIRDICFFCAAIGSLALILVYGKINFWGALGFC 231

  Fly   205 VMFLVYIFYILVNVVDVYLIRRALKTTNAQIDALLVGEMTPEKRKRLSELERNQAIYTRDMEVEI 269
            .::.||:.:::       |..|......|:.|...:     .||..|||     .|..||...||
plant   232 SLYAVYVAFVV-------LSWRFGGDQGAESDLESI-----HKRGSLSE-----PILQRDGLEEI 279

  Fly   270 FERTNSG------PNINKIRYTTLRMGRSTRISLDRKATRMVLHNRALGRNWGLFKDLFIALRPI 328
            .:...:|      .:.:..||...:              |:|:        |.:       ..|:
plant   280 EDGVVNGEHQIVDDDDDHQRYYYWK--------------RLVI--------WAI-------TLPL 315

  Fly   329 NCEKWRKGNIIKRAFMLTKIPAVIICCIYIPLVDYELDKHGWNKLLNCIQVMLNPAMSIMAIKAL 393
            |                  :|.::.    ||:|..  ||  |:|.|....|...|        .|
plant   316 N------------------LPRILT----IPVVSE--DK--WSKPLAVASVTFAP--------VL 346

  Fly   394 LSSRGNSLWYVAMGEEAIYA--MYSLPITVPIAVFMFIQSRTD---------VPPFYHSVFTVMN 447
            ||    .||.......:..|  :|.:...:.||: .||...|.         :.|:....| ||:
plant   347 LS----FLWNWKRKPTSFEAGVVYLIGCLIGIAL-GFIAGATTKKLTPPKKWLLPWLAGGF-VMS 405

  Fly   448 LTGSMFMIFICATEIDKVLEVIGHILKVEDDFMGATVKACTGSLGPLIANVAMALHG---YPRMA 509
            :|.|    :|.|.|:..:|..:|:|..|....:|.||.|...|:|.||.|:.||||.   ..::|
plant   406 MTWS----YISAQELVALLTSLGYIFGVSPSILGLTVLAWGNSIGDLITNLTMALHDGNEGAQVA 466

  Fly   510 YASAIGGPFFTVVMSASTVMHVKNLFG-----LPVSEANQTGNYGLNAFIFLNLGVFSTLLWSTT 569
            .:....||.|..:.:...     :|.|     .|:|...:|....|.:..||..|    |:||..
plant   467 VSGCYAGPIFNTLFALGI-----SLVGCAWEAYPLSIVIKTDPRLLESLGFLVAG----LVWSFL 522

  Fly   570 LGFFAR-RSVGIFSIVFYCIYLLFAILIHRKVIHSFSVDLPVKAAFGD 616
            :.|..| |..|:..|....|||.             |:.|.:....||
plant   523 VLFSNRMRLGGVMGIGLLVIYLA-------------SLSLRIMQTVGD 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	144/598 (24%)
		Na_Ca_ex	85..219	CDD:279963	38/147 (26%)
		Na_Ca_ex	448..595	CDD:279963	46/155 (30%)
AT5G17850	NP_001318589.1	PLN03151	34..556	CDD:215604	149/630 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I1872
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D478735at2759
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		mtm1105
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.940