Protein Alignment CG12376 and slc24a3

DIOPT Version :10

• Sequence 1: NP_610405.3
• Gene: CG12376 / 35857
• FlyBaseID: FBgn0033323
• Length: 617
• Species: Drosophila melanogaster
• Sequence 2: XP_012818629.1
• Gene: slc24a3 / 780317
• XenbaseID: XB-GENE-958238
• Length: 685
• Species: Xenopus tropicalis
• Alignment Length: 688
• Identity: 134/688 - (19%)
• Similarity: 252/688 - (36%)
• Gaps: 177/688 - (25%)

  Fly    20 WDTVSCY-AANTFPFEERCAFVASAKDCNR------STNVLPYMRIMACDLNC----VNEFEQ-- 71
            |...|.| :.:.|..:...|..||.|...|      ..||....|......||    ::||..
 Frog    74 WTEASGYKSIDYFDNDLNNAVEASDKWSGRGILWSSDENVTESQRETKHRKNCTEPALHEFPDDI 138

  Fly    72 ----------VIFLALF-MGLCYEILVLLIHVCNKYYSPALKAVSRFLCMNEHVAGVTLLAFGNS 125
                      ||...|| |.:.|.:.:    ||:.::.|:|:.:|..|.::|.|||.|.:|.|:|
 Frog   139 FSNEDRRHGAVILHVLFAMYMFYALAI----VCDDFFVPSLEKISERLQLSEDVAGATFMAAGSS 199

  Fly   126 SADLFSNLASV---NANVPVFANSLAAALF--------VSMVSGGLICYTSPFKMNAYESVRDIL 179
            :.:||:::..|   ..:|.| ...:.:|:|        ..:.:|.::.      ::|:..:||..
 Frog   200 APELFTSVIGVFITKGDVGV-GTIVGSAVFNILCIIGVCGLFAGQVVV------LSAWCLLRDAT 257

  Fly   180 FLIFGSMLLQYFLASSAHVPETSFIVMFLVYIFYILV----NVVDVYLIRRALK--------TTN 232
            :.....:.|..|:... .|.....:::.::|..|||:    :.:..:..||...        |.|
 Frog   258 YYTLSVIALIVFIYDE-KVSWWESLILVMMYAVYILIMKYNSSIHQFFERRKKSAANLANGLTAN 321

  Fly   233 AQIDALLVGEMTPEKRKRLSELERNQAIYTRDMEVEIFERTNSGPNINKIRYTTLRMGRSTRISL 297
            :::|..:..|.|.....: ....|..::...|..:..:....|..........|......||:|:
 Frog   322 SELDDSVHCEATMVLLNK-GNCNRKTSVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSM 385

  Fly   298 DRKATRMVLHNRALGRNWGLFKDLFIALRPINCEKWRKGNIIKRAFMLTKIPAVIICCIYIPLVD 362
               |:||:::.|.               |.||...:..|    .:.:..|||.
 Frog   386 ---ASRMLINERQ---------------RLINSRAYVNG----ESEVSIKIPI------------ 416

  Fly   363 YELDKHGWNKLLNCIQVMLNPAMSIMAIKALLSSRGNSLWYVAMGE------------------- 408
                ||       .::....|..|       ....|||.....:.|
 Frog   417 ----KH-------AVENGTGPGNS-------TERNGNSNRRDDVAEAGNETENENEDNENNENDE 463

  Fly   409 ---------EAIYAMYSLP----------ITVPIAVFMFIQSRTDVPPFYHSVFTVMNLTGSMFM 454
                     :..:..:.:|          :|.|:.:.::........|.:...|.|..::.||::
 Frog   464 EEEEEEDDNDGPFTPFEVPSGNADKVKWMVTWPLCLLLYFTVPNCAKPRWEKWFMVTFVSSSMWI 528

  Fly   455 IFICATEIDKVLEVIGHILKVEDDFMGATVKACTGSLGPLIANVAMALHGYPRMAYASAIGGPFF 519
            ..:....: .::.:||..|.:.|..||.|..|...|:...:|::.:|..|...||.:::||...|
 Frog   529 AALSYVMV-WMVTIIGFTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVF 592

  Fly   520 TVVMSASTVMHVKNLFGLPVSEANQTGNYGLNAFIFLN-------LGVFSTLLWSTTLGF-FAR- 575
            .:::.          .|||.:......:||  ::|.||       :.:....|:.|..|. |.:
 Frog   593 DILIG----------LGLPWALQTLAVDYG--SYIQLNSRGLIYSVALLLASLFVTVCGVRFNKW 645

  Fly   576 ---RSVGIFSIVFYCIYLLFAILIHRKVIHSFSVDLPV 610
               :.:|:..::.|.::|..:||....|. :| |:||:
 Frog   646 RLDKKLGVACLLLYGVFLCLSILTEFNVF-TF-VNLPM 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	123/654 (19%)
slc24a3	XP_012818629.1	2A1904	<129..670	CDD:273344	115/618 (19%)