DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12376 and SLC24A3

DIOPT Version :9

Sequence 1:	NP_610405.3	Gene:	CG12376 / 35857	FlyBaseID:	FBgn0033323	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_065740.2	Gene:	SLC24A3 / 57419	HGNCID:	10977	Length:	644	Species:	Homo sapiens

Alignment Length:	625	Identity:	129/625 - (20%)
Similarity:	232/625 - (37%)	Gaps:	148/625 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 NC----VNEFEQVIF--------LALFMGLC--YEILVLLIHVCNKYYSPALKAVSRFLCMNEHV 114
            ||    ::||...||        ..:...||  |....|.| ||:.::.|:|:.:...|.::|.|
Human    86 NCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAI-VCDDFFVPSLEKICERLHLSEDV 149

  Fly   115 AGVTLLAFGNSSADLFSNLASV---NANVPVFANSLAAALF-VSMVSGGLICYTSPFKMNAYES- 174
            ||.|.:|.|:|:.:||:::..|   ..:|.| ...:.:|:| :..:.|  :|.....::.|..|
Human   150 AGATFMAAGSSAPELFTSVIGVFITKGDVGV-GTIVGSAVFNILCIIG--VCGLFAGQVVALSSW 211

  Fly   175 --VRDILFLIFGSMLLQYFLASSAHVPETSFIVMFLVYIFYILV---NVVDVYLIRRALK----- 229
              :||.::.....:.|..|:... .|.....:|:.|:|:.||::   |........|..|
Human   212 CLLRDSIYYTLSVIALIVFIYDE-KVSWWESLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNM 275

  Fly   230 ----TTNAQIDALLVGEMTPEKRKRLSELERNQAIYTRDMEVEIFERTNSGPNINKIRYTTLRMG 290
                ..||:||.....:.|....|: :...|..::...|..:..:....|..........|....
Human   276 VNGLANNAEIDDSSNCDATVVLLKK-ANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFP 339

  Fly   291 RSTRISLDRKATRMVLHNRALGRNWGLFKDLFIALRPINCEKWRKGNIIKRAFMLTKIPAVIICC 355
            ..||:|:   |:||:::.|.               |.||...:..|    .:.:..|||.
Human   340 PKTRLSM---ASRMLINERQ---------------RLINSRAYTNG----ESEVAIKIPI----- 377

  Fly   356 IYIPLVDYELDKHGWNKLLNCIQVMLNPAMSIMAIKALLSSRGNSLWYVAMGE------------ 408
                       ||         .|......|....:.:..:|.:.:...|..|
Human   378 -----------KH---------TVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDE 422

  Fly   409 ---------EAIYAMYSLP----------ITVPIAVFMFIQSRTDVPPFYHSVFTVMNLTGSMFM 454
                     |..|..:..|          .|.|::..::........|.:...|.|   |.:...
Human   423 EEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMV---TFASST 484

  Fly   455 IFICATEIDKV--LEVIGHILKVEDDFMGATVKACTGSLGPLIANVAMALHGYPRMAYASAIGGP 517
            ::|.|.....|  :.:||:.|.:.|..||.|..|...|:...:|::.:|..|...||.:::||..
Human   485 LWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSN 549

  Fly   518 FFTVVMSASTVMHVKNLFGLPVSEANQTGNYGLNAFIFLN-------LGVFSTLLWSTTLGFFAR 575
            .|.:::.          .|||.:......:||  ::|.||       :|:....::.|..|....
Human   550 VFDILIG----------LGLPWALQTLAVDYG--SYIRLNSRGLIYSVGLLLASVFVTVFGVHLN 602

  Fly   576 -----RSVGIFSIVFYCIYLLFAILIHRKVIHSFSVDLPV 610
                 :.:|...::.|.::|.|:|:....|. :| |:||:
Human   603 KWQLDKKLGCGCLLLYGVFLCFSIMTEFNVF-TF-VNLPM 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	122/605 (20%)
		Na_Ca_ex	85..219	CDD:279963	37/143 (26%)
		Na_Ca_ex	448..595	CDD:279963	36/160 (23%)
SLC24A3	NP_065740.2	TIGR00367	112..605	CDD:273039	113/560 (20%)
		Na_Ca_ex	113..255	CDD:279963	39/146 (27%)
		Alpha-1	149..189		13/40 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..442		4/36 (11%)
		Na_Ca_ex	475..627	CDD:279963	38/166 (23%)
		Alpha-2	518..549		9/30 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840