DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12376 and slc8b1

DIOPT Version :9

Sequence 1:	NP_610405.3	Gene:	CG12376 / 35857	FlyBaseID:	FBgn0033323	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	XP_021333605.1	Gene:	slc8b1 / 560601	ZFINID:	ZDB-GENE-130530-900	Length:	301	Species:	Danio rerio

Alignment Length:	200	Identity:	48/200 - (24%)
Similarity:	92/200 - (46%)	Gaps:	32/200 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ERCAFVASAKDCNRSTNVLPYMRIMAC-------DLNCVNEFEQVIFLALFMGLCYEILVLLIHV 92
            :||.:|.:..||......:.|..:..|       .|........::||.|.:||          :
Zfish    65 QRCEYVKNTPDCASDEGFIKYPFVTFCLFTPSLLPLAITIYVIWLLFLFLVLGL----------I 119

  Fly    93 CNKYYSPALKAVSRFLCMNEHVAGVTLLAFGNSSADLFSNLASVN----ANVPVFANSLAAALFV 153
            .:.::.|.|.|::..|.:..:|||||.||.||.:.|:||.:|:.:    |.:.:.| ...|.:||
Zfish   120 ASDFFCPNLSAIASTLRLTHNVAGVTFLALGNGAPDVFSAMAAFSHPQTAGLAIGA-LFGAGIFV 183

  Fly   154 SMVSGGLICYTSPFKMNAYESVRDILF---LIFGSMLLQYFLASSAHV---PETSFIVMFLVYIF 212
            :.|..|.:....||.:.:...:||::|   .:|.:..:.|    ..|:   ....::.|::.|:|
Zfish   184 TTVVAGSVALVKPFTVASRPFLRDVIFYMAAVFWTFTVLY----KGHISLGESVGYLGMYIAYVF 244

  Fly   213 YILVN 217
            .::::
Zfish   245 TVILS 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	48/199 (24%)
		Na_Ca_ex	85..219	CDD:279963	35/142 (25%)
		Na_Ca_ex	448..595	CDD:279963
slc8b1	XP_021333605.1	Na_Ca_ex	66..>246	CDD:332332	48/194 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581763
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41602
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		otm26516
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.750