Protein Alignment CG12376 and slc24a3

DIOPT Version :9

• Sequence 1: NP_610405.3
• Gene: CG12376 / 35857
• FlyBaseID: FBgn0033323
• Length: 617
• Species: Drosophila melanogaster
• Sequence 2: XP_685302.4
• Gene: slc24a3 / 557196
• ZFINID: ZDB-GENE-090312-67
• Length: 660
• Species: Danio rerio
• Alignment Length: 647
• Identity: 130/647 - (20%)
• Similarity: 240/647 - (37%)
• Gaps: 189/647 - (29%)

  Fly    62 DLNC----VNEFEQVIF---------LALFMGLC--YEILVLLIHVCNKYYSPALKAVSRFLCMN 111
            |.||    ::||...||         :||.: ||  |....|.: ||:.|:.|:|:.:...|.::
Zfish    99 DKNCTPPGIHEFPDDIFTQQERLEGAVALHV-LCAMYMFYALAL-VCDDYFVPSLEKICERLHLS 161

  Fly   112 EHVAGVTLLAFGNSSADLFSNLASV---NANVPVFANSLAAALF-VSMVSGGLICYTS-PFKMNA 171
            |.|||.|.:|.|:|:.:||:::..|   ..:|.| ...:.:|:| :..:.|....:|: ..:::.
Zfish   162 EDVAGATFMAAGSSAPELFTSVIGVFITKGDVGV-GTIVGSAVFNILCIIGVCGIFTAQAVRLSC 225

  Fly   172 YESVRDILFLIFGSMLLQYFLASSAHV--PETSFIVMFLVYIFYILVNVVDVYLIRRALK----- 229
            :..:||..:.......|..|:......  .....||::||||..:..|...|:.|.|..|
Zfish   226 WTLMRDSTYYTIAVATLIVFIYDEKVTWWESLILIVLYLVYILIMKFNSRVVHFIERRKKNPANL 290

  Fly   230 ----TTNAQID------ALLVGEMTPEKRKRLSELERNQAIYTRDMEVEIFERTNSGPNINKIRY 284
                .:|..||      .:|:.:....::..:..::...:.|...:..     :.:|..|    .
Zfish   291 GNGTASNTDIDDGCDATVVLLKKANFHRKPSVLMVDELLSAYPHQLTF-----SEAGMRI----M 346

  Fly   285 TTLRMGRSTRISLDRKATRMVLHNRALGRNWGLFKDLFIALRPINCEKWRKGNIIKRAFMLTKIP 349
            .|......||:::   |:||::..|.               |.|| .::..|:    :.:..|:|
Zfish   347 ITSHFSPRTRLTM---ASRMLITERQ---------------RLIN-SRFSNGD----SEVTVKMP 388

  Fly   350 AVIICCIYIPLVDYELDKHGWNKLLNCIQVMLN-------------------------------- 382
            .                |.|....|......||
Zfish   389 G----------------KRGVENGLAGPDRGLNGRKGGHHDDDRGGAEAGTDTENENEDNENNEN 437

  Fly   383 -------------------PAMSIMAIKALLSSRGNSLWYVAMGEEAIYAMYSLPITVPIAVFMF 428
                               |...|..:|.||:      |                   |:::.:|
Zfish   438 DEEEEEEDENEGPYVPFRCPGGGINKLKWLLA------W-------------------PLSMLLF 477

  Fly   429 IQSRTDVPPFYHSVFTVMNLTGSMFMIFICATEIDKVLEVIGHILKVEDDFMGATVKACTGSLGP 493
            ........|.:...:.|..::.::::.|.....: .::.|||:.:.:.|..||.|..|...|:..
Zfish   478 FTVPNSANPRWERWYMVSFISSTIWIAFFSYIMV-WMVTVIGYTMGIPDVIMGITFLAAGTSVPD 541

  Fly   494 LIANVAMALHGYPRMAYASAIGGPFFTVVMSASTVMHVKNLFGLPVSEANQTGNYG----LNA-- 552
            .:|::.:|..|...||.:::||...|.:::.          .|||.:......|||    ||:
Zfish   542 CLASLIVARQGMGDMAISNSIGSNVFDILIG----------LGLPWALQTLAINYGSTIHLNSKG 596

  Fly   553 FIFLNLGVFSTLLWSTTLGFFAR-----RSVGIFSIVFYCIYLLFAILIHRKVIHSFSVDLP 609
            .|| ::|:....::.|.||....     :.:|...::.|.::|.|:|||... |.:| |:||
Zfish   597 LIF-SVGLLLASVFLTVLGVHLNNWKLDKRLGFACLLMYAVFLCFSILIEFN-IFTF-VNLP 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	121/628 (19%)
		Na_Ca_ex	85..219	CDD:279963	35/140 (25%)
		Na_Ca_ex	448..595	CDD:279963	36/157 (23%)
slc24a3	XP_685302.4	TIGR00367	127..637	CDD:273039	112/597 (19%)
		Na_Ca_ex	128..270	CDD:279963	37/144 (26%)
		Na_Ca_ex	491..643	CDD:279963	37/163 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840