DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12376 and CG14743

DIOPT Version :9

Sequence 1:	NP_610405.3	Gene:	CG12376 / 35857	FlyBaseID:	FBgn0033323	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_610408.2	Gene:	CG14743 / 35860	FlyBaseID:	FBgn0033326	Length:	611	Species:	Drosophila melanogaster

Alignment Length:	629	Identity:	186/629 - (29%)
Similarity:	323/629 - (51%)	Gaps:	57/629 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PNAFDAEFDNFWDTVSCYAANTFPFEERCAFVASAKDCNRSTNVLPYMRIMACDLNCVNEFEQVI 73
            |.:|..|.| |...|||.|...|.:..||.......||...||...|..:|.|.....|:..:::
  Fly    11 PYSFLNESD-FMQNVSCLAVMHFSYLHRCEMATKIDDCKYITNFFNYYVMMYCSFKIDNKITEIV 74

  Fly    74 FLALFMGLCYEILVLLIHVCNKYYSPALKAVSRFLCMNEHVAGVTLLAFGNSSADLFSNLASVNA 138
            .:.||..:....|.:|....|.|::|.||..:..:.:||::|||.|:...||:.||..||:.|..
  Fly    75 VMLLFALIYCFFLCILYEGVNSYFAPTLKIAALKMRINEYMAGVVLVGVANSTPDLLVNLSPVRM 139

  Fly   139 NVPVFANSLAAALFVSMVSGGLICYTSPFKMNAYESVRDILFLIFGSMLLQYFLASSAHVPETSF 203
            ....|..::|.||.:..:|||.:|:..||:||.:...||:|||:....|:::|:..:|..|....
  Fly   140 EGLTFNIAMANALTIICLSGGAVCFIRPFRMNGHSIFRDLLFLLLIIELVRFFMNDTALAPWIKG 204

  Fly   204 IVMFLVYIFYILVNVVDVYLIRRALKTTNAQIDALLVGEMTPEKRK----------RLSELERNQ 258
            .::..:|..|:|:|:||:.|:|.|::...|.|:.|   ..:|..|:          ||:.|:
  Fly   205 AILLSIYPIYLLINIVDLILLRYAIRKLRADIEVL---RQSPSSREHDLILTEKIVRLNNLQ--- 263

  Fly   259 AIYTRDMEVEIFE------RT-NSG------PNINKIRYTTLRMGRSTRISLDRKATRMVLHNRA 310
                :|.|::|.|      || |:|      |.|:             ...:|.:..|.:||::|
  Fly   264 ----QDDEIQILESKLYRKRTYNAGFFVTPKPLIH-------------HKEVDVETNRRILHSKA 311

  Fly   311 LGRNWGLFKDLFIALRPINCEKWRKGNIIKRAFMLTKIPAVIICCIYIPLVDYELDKHGWNKLLN 375
            ..:|..||.:...|:.||:.|.|.......|...:.|.|..::..:.:|||||:|.||||:|:||
  Fly   312 NPKNLFLFSEFLQAINPIDSEGWYLSGTCARILQILKAPVTLMLHLVVPLVDYQLVKHGWSKMLN 376

  Fly   376 CIQVMLNPAMSIMAIKALLSSRGNSLWYVAMGEEAIYAMYSLPITVPIAVFMFIQSRTDVPPFYH 440
            |:|::|.|.:....::.:|..:....:||.....||   :||.:|:|:|:.:|:.||||:|||||
  Fly   377 CLQIVLTPFVIFALVETMLVHKYAEWYYVPQFRMAI---WSLLVTMPLAIVVFLHSRTDIPPFYH 438

  Fly   441 SVFTVMNLTGSMFMIFICATEIDKVLEVIGHILKVEDDFMGATVKACTGSLGPLIANVAMALHGY 505
            |.:..:.::..:...:|||.|:|.::.:||.:..:...:|..|..:.:.:...|||...:|.|||
  Fly   439 SSYCALTISTVIIFFWICAWEMDALISIIGVVFDLAPSYMSITFNSVSAATADLIAYAHLAKHGY 503

  Fly   506 PRMAYASAIGGPFFTVVMSASTVMHVKNLFGLPVSEANQT---GNYGLNAFIFLNLGVFSTLLWS 567
            .:||:.:.|||..:::.::..    ::.:....::...|.   |:.|:..:|||.:.:.:||.|.
  Fly   504 GKMAFGAIIGGSVYSLAVNVG----IELVLQKKLNSRGQVVLYGDDGVTIYIFLVITITTTLWWC 564

  Fly   568 TTLGFFARRSVGIFSIVFYCIYLLFAILIHRKVIHSFSVDLPVK 611
            .|..|.||||.|:|....:.::|::...|..:.:|.|..::.::
  Fly   565 LTFNFVARRSAGLFMWSLFVLFLVYTTAIELQWVHGFQDNIQIR 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	173/584 (30%)
		Na_Ca_ex	85..219	CDD:279963	45/133 (34%)
		Na_Ca_ex	448..595	CDD:279963	39/149 (26%)
CG14743	NP_610408.2	Na_Ca_ex	77..220	CDD:279963	47/142 (33%)
CG14743	NP_610408.2	Na_Ca_ex	450..591	CDD:279963	39/144 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450098
Domainoid	1	1.000	91	1.000	Domainoid score	I14182
eggNOG	1	0.900	-	-		E1_COG0530
Homologene	1	1.000	-	-		H41602
Inparanoid	1	1.050	131	1.000	Inparanoid score	I1872
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		otm26516
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	P	PTHR12266
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X612
	14	13.760