Protein Alignment CG12376 and SLC24A5

DIOPT Version :9

• Sequence 1: NP_610405.3
• Gene: CG12376 / 35857
• FlyBaseID: FBgn0033323
• Length: 617
• Species: Drosophila melanogaster
• Sequence 2: NP_995322.1
• Gene: SLC24A5 / 283652
• HGNCID: 20611
• Length: 500
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 113/582 - (19%)
• Similarity: 209/582 - (35%)
• Gaps: 178/582 - (30%)

  Fly    61 CDLNCVNEFEQVIF----------LALFMGLCYEILVLLIHVCNKYYSPALKAVSRFLCMNEHVA 115
            |.::..:||.:..|          :..|:.:.|..:.:.| ||::|:.|:|:.:|..|.:::.||
Human    46 CVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISI-VCDEYFLPSLEIISESLGLSQDVA 109

  Fly   116 GVTLLAFGNSSADLFSNLASVNANVPVF--------ANSLAAALF-----------VSMVSGGLI 161
            |.|.:|.|:|:.:|      |.|.:.||        :..|.:|::           :|.....|.
Human   110 GTTFMAAGSSAPEL------VTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLS 168

  Fly   162 CYTSPFKMNAYE-SVRDILFLIFGSMLLQYFLASSAHVPETSFIVMFLVYIFYILVNVVDV---- 221
            |:.......||. |...:|.:|:.:.:..|..|           ::.|:|..|:||...|:
Human   169 CWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGA-----------LLLLIYGLYVLVLCFDIKINQ 222

  Fly   222 YLIRRALKTTNAQIDALLVGEMTPEKRKRLSELERNQAIYTRDMEVEIFERTNSGPNINKIRYTT 286
            |:|::.     :...|.|...|...:::.|...|.....:.|..     .||:||.......|:.
Human   223 YIIKKC-----SPCCACLAKAMERSEQQPLMGWEDEGQPFIRRQ-----SRTDSGIFYEDSGYSQ 277

  Fly   287 LRMGRSTRISLDRKATRMVLHNRALGRNWGLFKDLFIALRPINCEKWRKGNIIKRAFMLTKIPAV 351
            |.:.               ||        ||.:   ::..|.:.....:.: :||.|.:..:|.:
Human   278 LSIS---------------LH--------GLSQ---VSEDPPSVFNMPEAD-LKRIFWVLSLPII 315

  Fly   352 IICCIYIPLVDYELDKHGWNKLLNCIQVMLNPAMSIMAIKALLSSRGNSLWYVAMGEEAIYAMYS 416
            .:..:..|    :..|..|.              :...|...:|    ::|
Human   316 TLLFLTTP----DCRKKFWK--------------NYFVITFFMS----AIW-------------- 344

  Fly   417 LPITVPIAVFMFIQSRTDVPPFYHSVFTVMNLTGSMFMIFICATEIDKVLEVIGHILKVEDDFMG 481
                  |:.|.:|                        :::        ::.:.|..|::.|..||
Human   345 ------ISAFTYI------------------------LVW--------MVTITGETLEIPDTVMG 371

  Fly   482 ATVKACTGSLGPLIANVAMALHGYPRMAYASAIGGPFFTVVMSASTVMHVKNLF--GLPVSEANQ 544
            .|:.|...|:...||:|.:|..|...||.::.:|...|. ::.......:|..|  |...:|.|.
Human   372 LTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFD-MLCLGIPWFIKTAFINGSAPAEVNS 435

  Fly   545 TG----NYGLN-AFIFLNLGVFSTLLWSTTLGFFARRSVGIFSIVFYCIYLLFAILIHRKVI 601
            .|    ...|| :.|||.|.|...       |:...|.:||..::.|......::|....:|
Human   436 RGLTYITISLNISIIFLFLAVHFN-------GWKLDRKLGIVCLLSYLGLATLSVLYELGII 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	111/571 (19%)
		Na_Ca_ex	85..219	CDD:279963	37/153 (24%)
		Na_Ca_ex	448..595	CDD:279963	35/153 (23%)
SLC24A5	NP_995322.1	Na_Ca_ex	<20..>224	CDD:332332	44/195 (23%)
		Na_Ca_ex	<290..490	CDD:332332	50/282 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810