DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12376 and SLC24A2

DIOPT Version :9

Sequence 1:	NP_610405.3	Gene:	CG12376 / 35857	FlyBaseID:	FBgn0033323	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_001362779.1	Gene:	SLC24A2 / 25769	HGNCID:	10976	Length:	661	Species:	Homo sapiens

Alignment Length:	603	Identity:	124/603 - (20%)
Similarity:	238/603 - (39%)	Gaps:	133/603 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 DLNCVNEFEQVIFLALFMGLCYEILVLLIHVCNKYYSPALKAVSRFLCMNEHVAGVTLLAFGNSS 126
            |:..:.|..:...:...:|:.|..:.|.| ||::::.|:|..::..|.:::.|||.|.:|.|.|:
Human   123 DIFSLEERRKGAIILHVIGMIYMFIALAI-VCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSA 186

  Fly   127 ADLFSNLASV---NANVPVFANSLAAALFVSMVSGGLICYTSPFKMNA--YESVRDILFLIFGSM 186
            .:||::|..|   ::||.: ...:.:|:|..:...|:....|...:|.  :...||:.|.|...:
Human   187 PELFTSLIGVFIAHSNVGI-GTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLI 250

  Fly   187 LLQYFLASSAHVPETSFIVM--FLVYIFYILVNVVDVYLIRRALKTTNAQIDALLVGEMT-PEKR 248
            :|..|...:..:...|.:::  :..|:.::..||       :..|.....|:...|.::| ||.:
Human   251 MLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNV-------QVEKWVKQMINRNKVVKVTAPEAQ 308

  Fly   249 KRLSELERNQAIYTRDMEVEIFERTNSGPNINKIRYTTLRMGRSTRISLDRKATRMVLHNRALGR 313
            .:.|.                 .|....|.:            ..:..|.|..:...||| :|.|
Human   309 AKPSA-----------------ARDKDEPTL------------PAKPRLQRGGSSASLHN-SLMR 343

  Fly   314 NWGLFKDLFIALRPINCE-------KW-----RKGNIIKRAFMLTKIPAVIICCIYIPLVDYELD 366
            | .:|:.:...|.|:..|       |:     .:|...::|.:|.|| |...|     .||   :
Human   344 N-SIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKI-AKKKC-----HVD---E 398

  Fly   367 KHGWNKLLNCIQVMLNPAMSIMAIKALLSS-------RGN---------------------SLWY 403
            ....|...|.::.:..|..:...::...||       .||                     ||.:
Human   399 NERQNGAANHVEKIELPNSTSTDVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLSLAW 463

  Fly   404 VAMGEEAIYAMYSLPITVPIAVFMFIQSRTDVPPFYHSVFTVMNLTGSMFMIFICATEIDKVLEV 468
            .:...:.:..:...||..|:.:.:     .||.......|..:...||:..|.:.:..:......
Human   464 PSETRKQVTFLIVFPIVFPLWITL-----PDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQ 523

  Fly   469 IGHILKVEDDFMGATVKACTGSLGPLIANVAMALHGYPRMAYASAIGGPFFTVVMSAS------T 527
            :|..:.:.::.||.|:.|...|:..||.:|.:|..|...||.:|::|...|.:.:...      |
Human   524 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYT 588

  Fly   528 VMHVKNLFGLPVSEANQTGNYGLNA-----FIFLNLGVFSTLL--W--STTLGFFARRSVGIFSI 583
            |:|...    ||:.::.    ||..     ||.|...:.|..|  |  :..|||.      :|.:
Human   589 VIHRFQ----PVAVSSN----GLFCAIVLLFIMLLFVILSIALCKWRMNKILGFI------MFGL 639

  Fly   584 VFYCIYLLFAILIHRKVI 601
              |.::|:.::|:..:::
Human   640 --YFVFLVVSVLLEDRIL 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	123/592 (21%)
		Na_Ca_ex	85..219	CDD:279963	34/140 (24%)
		Na_Ca_ex	448..595	CDD:279963	38/161 (24%)
SLC24A2	NP_001362779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	99..120
		2A1904	<115..661	CDD:273344	124/603 (21%)
		Alpha-1	174..214		14/40 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..336		6/58 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..439		7/44 (16%)
		Alpha-2	541..572		11/30 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810