DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12376 and SPAC3A12.06c

DIOPT Version :9

Sequence 1:	NP_610405.3	Gene:	CG12376 / 35857	FlyBaseID:	FBgn0033323	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_593332.1	Gene:	SPAC3A12.06c / 2543183	PomBaseID:	SPAC3A12.06c	Length:	743	Species:	Schizosaccharomyces pombe

Alignment Length:	739	Identity:	145/739 - (19%)
Similarity:	258/739 - (34%)	Gaps:	205/739 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FWD--------TVSCYAANTFPFEERCAFVASAKD-----CNRSTNVLPYMRIMACDLNCVNE-- 68
            ||.        :||..:.:|....||...:..:.|     ||...|:.|..:.......|..|
pombe    27 FWTHRISKAFASVSSTSDSTVHLFERGNTLNDSNDQILLTCNDIKNITPANQCRFAKAYCKGEAS 91

  Fly    69 --FEQVIF------------LALFMGLCYEILVLLIHVCNKYYSPALKAVSRFLCMNEHVAGVTL 119
              |:.|.|            |::.:|....:.:.:....:.::|..|..:|..|.:.:.|.|||.
pombe    92 GFFDYVEFYFCTINSLRFPVLSIIVGWLIFLFITIGISASDFFSTNLVTISWLLQLPDSVVGVTF 156

  Fly   120 LAFGNSSADLFSNLASVNANVPVFA--NSLAAALFVSMVSGGLICYTSPFKMNAYESVRDILFLI 182
            ||.||.|.|:.|..|:|..|....|  ..|.:|.|:..:..|.:|...|||:.....:||:.||.
pombe   157 LALGNGSPDILSTFAAVRVNSGGMAIGELLGSAFFIVAIVAGSVCLIKPFKIPRRHFLRDVAFLT 221

  Fly   183 FGSMLLQYFLASSAHVPETSFIVMFLVYIFYIL---------VNVV------------------- 219
            ...:|:..|:.....:.....:||.|.|:.|:|         |:||
pombe   222 GTILLVIMFVLHDGSLSIWQSLVMILYYLLYVLFVFFSGSSGVSVVITDENYLPVSLPVYSPVLN 286

  Fly   220 -----DVYLIRRALKTTNAQI--DALLVGEMTPEKRKRLSELERNQ-----AIYTRDMEVEIFER 272
                 |.|      .:|::::  :|.|:......|.:::..:..|.     :.|......:...:
pombe   287 SFDDSDSY------SSTDSELSEEAFLLPAQASRKTQKIHYINDNDPSNSYSSYQHSHVHDFIHK 345

  Fly   273 TN----------SGPNI-------------NKIRYTTLR-------------------------- 288
            .|          |||.:             |:.::..||
pombe   346 NNTHSNRVLSQSSGPIVRPSLLAALDFRSSNEEQHPGLRSLDPLNIQDGDLTMHPMHIRHSQSDF 410

  Fly   289 ----------------MGRSTRISLDRKATRMVLHNRALGRNW-----GLFKDLFIALRPINCEK 332
                            :|.|...|:....:.:..|......::     .|...||..||....:.
pombe   411 YPSGINTPVSGINYPNLGFSANNSVQSLVSEIFRHPTHTDEDFPLPSPSLSSLLFPTLRNFAKKS 475

  Fly   333 WRKGNIIKRAFMLTKIPAVIICCIYIPL-------VD--YELD-------KHGWNKLLNCIQVML 381
            |     .::...:..:|:|:|..:.:|:       ||  |.:|       |..|::.|..:|.:.
pombe   476 W-----YEKLMDVLAVPSVLIFTLALPVYQCPRLAVDPIYHMDVSNCNPSKPTWSRKLRLLQCVF 535

  Fly   382 NPAMSIMAIKALLSSRGNSLWYVAMGEEAIYAMYSLPITVPIAVFMFIQSRTDVPPFYHSVFTVM 446
            .|    .|......:.||.|:        |||..|: .::.....::..:..:.||.:....:.:
pombe   536 VP----FAFVTFSITGGNRLY--------IYAASSV-FSILCITALYYYTDEEKPPKFLPWVSFI 587

  Fly   447 NLTGSMFMIFICATEIDKVLEVIGHILKVEDDFMGATVKACTGSLGPLIANVAMALHGYPRMAYA 511
            .....:..|...|.|:..:|..:|.|..:.:..:|.||.|...||..|||::.:|..|:|.||..
pombe   588 GFVLGIIWISTIANEVVGILRALGVIFNLNESILGLTVFAAGNSLSDLIADIMIARSGFPEMAMG 652

  Fly   512 SAIGGPFFTVVMSASTVMHVKNLFGLPVSE-ANQTGNYGLNAFI-----------FLNLGVFSTL 564
            ...|||...:            |.|:.:|. .:...|:|.::.|           ||...:...|
pombe   653 GVFGGPTLNI------------LIGIGISSFYSSISNHGNDSVIEIPHSLSITAYFLLACLLLLL 705

  Fly   565 LWSTTLGFFARRSVGIFSIVFYCI 588
            ::.....|...|.:|:...:.|.:
pombe   706 IYVPLNRFRVNRVLGLLLFILYIV 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	140/717 (20%)
		Na_Ca_ex	85..219	CDD:279963	40/144 (28%)
		Na_Ca_ex	448..595	CDD:279963	36/153 (24%)
SPAC3A12.06c	NP_593332.1	PLN03151	76..729	CDD:215604	133/688 (19%)
		Na_Ca_ex	118..258	CDD:279963	39/139 (28%)
		Na_Ca_ex	584..729	CDD:279963	36/156 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	73	1.000	Domainoid score	I2545
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I1261
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	LDO	PTHR12266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	1	1.000	-	-		X612
TreeFam	1	0.960	-	-
	11	10.850