Protein Alignment CG12376 and ncx-10

DIOPT Version :9

• Sequence 1: NP_610405.3
• Gene: CG12376 / 35857
• FlyBaseID: FBgn0033323
• Length: 617
• Species: Drosophila melanogaster
• Sequence 2: NP_001256094.1
• Gene: ncx-10 / 190821
• WormBaseID: WBGene00003575
• Length: 668
• Species: Caenorhabditis elegans
• Alignment Length: 668
• Identity: 145/668 - (21%)
• Similarity: 265/668 - (39%)
• Gaps: 162/668 - (24%)

  Fly    25 CYAANTFPFEERCAFVASAKDCNRSTNVLPYMRIMACD----LNCVNEFEQVIFLALFMGLCYEI 85
            |.....:..|:.||::...||.......|.:...:.|:    :..:.....:|:| ||      :
 Worm    57 CLIQKHWTREDTCAYIKCNKDACEGGGYLQWSEYIKCEHSRSIRIILIIISIIYL-LF------L 114

  Fly    86 LVLLIHVCNKYYSPALKAVSRFLCMNEHVAGVTLLAFGNSSADLFSNLASV------NANVPVFA 144
            .|::..|.:.::||::..:.|.|.::|.:||||.|||||.:.|:|.::|||      .|::.: .
 Worm   115 FVVMTVVADDFFSPSIAGIVRHLKISESIAGVTFLAFGNGAPDVFGSIASVITTPKPKADLAI-G 178

  Fly   145 NSLAAALFVSMVSGGLICYTSPFKMNAYESVRDILFLIFGSMLLQYFLASSAHVPETSFIVMFLV 209
            :.:...:||:.|....|..|..|::....::|||:|.|...:.|..:..:..||.    |.|.|.
 Worm   179 DIIGGGIFVTTVVLSAIILTKSFRIAILATIRDIVFFIIADIFLAIWFLTFNHVE----IWMPLT 239

  Fly   210 YIFYILVNVVDVYLIRRALKTTNAQIDALLVGEMTPEKRKR-----LSELERNQAIYTRDMEVEI 269
            ::......||.|.|:|                 :..::|||     :....:..|:.....::..
 Worm   240 FLGLYAAYVVSVILMR-----------------LNSKRRKRARHEKIENARKESAMNHHTHKIST 287

  Fly   270 F--------------------ERTNSGPNINKIRYTTLRMGRSTRISLDR--KATRMVLHNRA-- 310
            |                    ..||:..|....:..:|..|.....|.|.  :|.....|...
 Worm   288 FIGFFMDYAHVINFFANNKISSMTNNVKNFLDGKEDSLEDGLVDETSDDEGVEAEFHYAHRHVYK 352

  Fly   311 ------------------LGRNWGLFKDLFIALRPINCEKWRKGN-----------------IIK 340
                              ..::|...:|:...|||     | .||                 :|.
 Worm   353 SYDEASLAFTDVEEIQPKTWKSWEWVRDVRNHLRP-----W-PGNDEFYEMNYFSRFITVVAVIP 411

  Fly   341 RAFMLTKIPAVIICCIYIPLVDYELDKHGWNK---LLNC---IQVMLNPAMSIMAIKALLSSRGN 399
            ..|:...||:               ::..|:|   :::|   ||:.|. |:.|.|......|.|
 Worm   412 TFFLKLTIPS---------------NEMPWSKPILIIHCFCSIQLALF-AVQISAKSPFHGSPG- 459

  Fly   400 SLWYVAMGEEAIYAMYSLPITVPIAVFMFIQSRTD-VPPFYHSVFTVMNLTGSMFMIFICATEID 463
             ||           :|.|.|::.:::.....:..| ...:|..|::.:....|:..|:..::||.
 Worm   460 -LW-----------LYGLLISIILSLLALRFTPLDREQKYYREVYSYLGFLMSIAWIYTISSEII 512

  Fly   464 KVLEVIGHILKVEDDFMGATVKACTGSLGPLIANVAMALHGYPRMAYASAIGGPFFTVVMS---- 524
            .|:.:||....|..:.:|.|:.|.:..:|.::::||:...|:|:||.|:|||||.|:.:.|
 Worm   513 NVITMIGVATGVSQEILGLTIMAWSNCIGDIVSDVAVVKQGFPKMAMAAAIGGPLFSKLYSRPCQ 577

  Fly   525 ASTVMHVKNL---FGLPVSEANQTGN---------YGLNAFIFLNLGVFSTLLWSTTLGFFARRS 577
            .....::.:|   ||||.:.|...|.         |.| ..:||.:.:|::|:......|..|..
 Worm   578 IKITTYISDLLIGFGLPFTIACLQGKQIDLIITPVYRL-LMLFLAISLFTSLIAIFVQRFKVRWP 641

  Fly   578 VGIFSIVFYCIYLLFAIL 595
            ..:..:..:..:|:|.:|
 Worm   642 HAVALLTVFVAFLIFVLL 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	142/655 (22%)
		Na_Ca_ex	85..219	CDD:279963	39/139 (28%)
		Na_Ca_ex	448..595	CDD:279963	43/162 (27%)
ncx-10	NP_001256094.1	PLN03151	35..571	CDD:215604	126/577 (22%)
		Na_Ca_ex	113..253	CDD:279963	43/150 (29%)
		Na_Ca_ex	492..659	CDD:279963	43/167 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I5893
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41602
Inparanoid	1	1.050	162	1.000	Inparanoid score	I2840
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		mtm4752
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.930