Protein Alignment CG12376 and ncx-6

DIOPT Version :9

• Sequence 1: NP_610405.3
• Gene: CG12376 / 35857
• FlyBaseID: FBgn0033323
• Length: 617
• Species: Drosophila melanogaster
• Sequence 2: NP_499146.2
• Gene: ncx-6 / 182354
• WormBaseID: WBGene00003571
• Length: 590
• Species: Caenorhabditis elegans
• Alignment Length: 616
• Identity: 164/616 - (26%)
• Similarity: 267/616 - (43%)
• Gaps: 141/616 - (22%)

  Fly    35 ERCAFVASAKDCNRSTNVLPYMRIMAC-DLNCVN-------------EFEQVIFLALFMGLCYEI 85
            |:|...|..    .||.|..|::   | |.||..             ....|..:.:..|:.| :
 Worm    51 EQCTIQAGW----NSTQVCEYVK---CNDDNCEGGGYVLWTRYVECASSPAVRIILIITGVIY-M 107

  Fly    86 LVLLIHV---CNKYYSPALKAVSRFLCMNEHVAGVTLLAFGNSSADLFSNLASVNANVPVFANSL 147
            |||.|.|   .:.::||::.::...|.::|.|||||.:||||.:.|:|..:|||.:: |.....|
 Worm   108 LVLFIMVSSAADDFFSPSISSIVAHLRISESVAGVTFMAFGNGAPDVFGAIASVLSS-PTPKADL 171

  Fly   148 A------AALFVSMVSGGLICYTSPFKMNAYESVRDILFLIFGSMLLQYFLASSAHVPETSFIVM 206
            |      |.|||:.:...:..:|.|||...:.|:|||.|.:.....|.:......|| |....:.
 Worm   172 ALGELFGAGLFVTTMVLAVTIFTRPFKAEVFSSIRDIAFYLVALAFLAFCFVYYDHV-EIWMPIT 235

  Fly   207 FL-VYIFYILVNVVDVYLIRRALKTTNAQIDALLVGEMTPEKRKRLSELERNQAIYT-------- 262
            || ||:.|:...::...|..|..|      |...|.|:   |......||.:..||.
 Worm   236 FLGVYLIYVCTVILSQILHNRHKK------DEEKVDEV---KTVDTDSLEDDDDIYVSHGHHVLH 291

  Fly   263 ------RDMEVEIFERTNSGPNINKIRYTTLRMGRSTRISLDRKATRMVLHNRALGRNWGLFKDL 321
                  .:.|:|..|                        .|...:.|.|:|:         ||:
 Worm   292 AHEVMKMEAEIEAVE------------------------PLKTWSFRGVVHD---------FKE- 322

  Fly   322 FIALRP-INCEKWRKGNIIKRAF-MLTKIPAVIICCIYIPLVDYELDKHGWNKLLNCIQVMLNPA 384
              .|:| .:.::|.:.||.::.. :|..||..:. .:.||     ..:..|:|.:..:|.::.|.
 Worm   323 --HLKPWPSMDEWDEMNIFQKVIAVLNTIPNFLF-KLTIP-----HSEQPWSKPITLLQCLICPV 379

  Fly   385 MSIMAIKAL-LSSRGNS--LWYVAMGEEAIYAMYSLPITVPI--AVFMFIQSRTDVPPFYHSVFT 444
            ..:..|:.. :|...||  ||           ||.|.::|.:  ||..|.:...: ||||.|:.:
 Worm   380 FLLFCIQVCSISPFPNSPGLW-----------MYGLILSVLLTAAVLFFTELHKE-PPFYKSLIS 432

  Fly   445 VMNLTGSMFMIFICATEIDKVLEVIGHILKVEDDFMGATVKACTGSLGPLIANVAMALHGYPRMA 509
            ......|:..|::.::|:..|:.::|.:.:|..:.:|.|:.|.:.|:|.|||:|::|..||||||
 Worm   433 YAGFLMSIAWIYLISSEVVNVVTMLGVVSRVSHEVLGLTILAWSNSIGDLIADVSVAKQGYPRMA 497

  Fly   510 YASAIGGPFFTVVMSASTVMHVKNLFGLPVSEANQTG---------NYGLNAFIFLNLGVFSTLL 565
            .|:||||..|.:::.          ||||.:.|...|         .|.| ..:||.:.:..||:
 Worm   498 MAAAIGGQLFNLLIG----------FGLPFTIAKIQGKSISMIINPTYRL-LMLFLAISLIFTLI 551

  Fly   566 WSTTLGFFARRSVGIFSIVFYCIYLLFAILI 596
            ......:|.|| :..:|:||  ||:.|.:.|
 Worm   552 AMFAQKYFLRR-IHSYSLVF--IYISFFVFI 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	162/610 (27%)
		Na_Ca_ex	85..219	CDD:279963	48/143 (34%)
		Na_Ca_ex	448..595	CDD:279963	49/155 (32%)
ncx-6	NP_499146.2	Na_Ca_ex	105..249	CDD:279963	49/146 (34%)
		Na_Ca_ex	431..579	CDD:279963	49/161 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165710
Domainoid	1	1.000	75	1.000	Domainoid score	I5893
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41602
Inparanoid	1	1.050	162	1.000	Inparanoid score	I2840
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	1	1.010	-	-		QHG57812
OrthoDB	1	1.010	-	-		D257493at33208
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		mtm4752
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	O	PTHR12266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750