Protein Alignment CG12376 and Slc8b1

DIOPT Version :9

• Sequence 1: NP_610405.3
• Gene: CG12376 / 35857
• FlyBaseID: FBgn0033323
• Length: 617
• Species: Drosophila melanogaster
• Sequence 2: NP_573484.2
• Gene: Slc8b1 / 170756
• MGIID: 2180781
• Length: 585
• Species: Mus musculus
• Alignment Length: 631
• Identity: 154/631 - (24%)
• Similarity: 261/631 - (41%)
• Gaps: 129/631 - (20%)

  Fly    12 FDAEFDNFWDTVSCYAANTFPFEERCAFVASAKDCNRSTNVLPYMRIMACDLNCVNEFEQVIFLA 76
            |.|...|......|.|.......:||.||....||......|.|:..:.|... .|.....|.|.
Mouse    40 FSAGSVNQTAMADCRAVCGLNTSDRCDFVRRNPDCRSEAGYLDYLEGIFCYFP-PNLLPLAITLY 103

  Fly    77 LFMGLCYEILVLLIHVCNKYYSPALKAVSRFLCMNEHVAGVTLLAFGNSSADLFSNLASVN---- 137
            :|. |.|..|:|.: ...|::.|.|.|:|..|.::.:|||||.|||||.:.|:||.|.:.:
Mouse   104 VFW-LLYLFLILGV-TAAKFFCPNLSAISTNLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPRT 166

  Fly   138 ANVPVFANSLAAALFVSMVSGGLICYTSPFKMNAYESVRDILFLIFGSMLLQYFLASSAHVPETS 202
            |.:.:.|...|..|..::|:|| |....||...:...:|||.|.:....|              :
Mouse   167 AGLAIGALFGAGVLVTTVVAGG-ITILHPFMAASRPFLRDIAFYMVAVFL--------------T 216

  Fly   203 FIVMFL-------------VYIFYILVNVVDVYLIRRALKTTNAQIDALLVGEM--TPEKRKRLS 252
            |..::|             :|:||::..::..::.:|       |....||..:  |||   .||
Mouse   217 FTALYLGRITLTWALGYLGLYVFYVVTVIICTWVYQR-------QRSRSLVHSISETPE---LLS 271

  Fly   253 ELERNQAIYTRDMEVEIFERTNS---GPNINKIRYTTLRMGRSTRISLDRKATRMVLHNRALGRN 314
            |.|.:|          :...|||   |.     .|..|.:||.|.:.:
Mouse   272 ESEEDQ----------MSSNTNSYDYGD-----EYRPLLLGRETTVQI----------------- 304

  Fly   315 WGLFKDLFIALRPINCEKWRKGNIIKRAFMLTKIPAVIICCIYIPLVDYELDKHGWNKLLNCIQV 379
                  |..||.|::..|||..:|..|...:.|:|...:..:.:|:||.:.|...|.:.|||:|:
Mouse   305 ------LIQALNPLDYRKWRTQSISWRVLKVVKLPVEFLLLLTVPVVDPDKDDRNWKRPLNCLQL 363

  Fly   380 MLNPAMSIMAIKALLSSRGNSLWYVAMGEEAIYAMYSLPITVPI------------AVFMFIQSR 432
            :::|.:.::.:                 :..:|.:|.:...:|:            :|..|..|.
Mouse   364 VISPLVLVLTL-----------------QSGVYGIYEIGGLLPVWAVVVIVGTALASVTFFATSN 411

  Fly   433 TDVPPFYHSVFTVMNLTGSMFMIFICATEIDKVLEVIGHILKVEDDFMGATVKACTGSLGPLIAN 497
            .: ||..|.:|..:....|...|...|||:..:|..:|.|.::.:..:|.|:.|...|:|...::
Mouse   412 RE-PPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVIFRLSNTVLGLTLLAWGNSIGDAFSD 475

  Fly   498 VAMALHGYPRMAYASAIGGPFFTVVMSAS---TVMHVKNLFGLPVSEANQTGNYGLNAFIF---L 556
            ..:|..||||||:::..||..|.:::...   .:..::|    .|.|.....: ||..::.   |
Mouse   476 FTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQIIRN----HVVEVKLEPD-GLLVWVLASAL 535

  Fly   557 NLGVFSTLLWSTTLGFFARRSVGIFSIVFYCIYLLFAILIHRKVIH 602
            .|.:..:|:......|...::.|:..::||..:|:..:|....|||
Mouse   536 GLSLIFSLVSVPLQCFQLSKAYGLCLLLFYICFLVVVLLTEFGVIH 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	145/598 (24%)
		Na_Ca_ex	85..219	CDD:279963	42/150 (28%)
		Na_Ca_ex	448..595	CDD:279963	36/152 (24%)
Slc8b1	NP_573484.2	Na_Ca_ex	103..246	CDD:279963	45/159 (28%)
		Na_Ca_ex	421..574	CDD:279963	37/157 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837966
Domainoid	1	1.000	73	1.000	Domainoid score	I9194
eggNOG	1	0.900	-	-		E1_COG0530
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41602
Inparanoid	1	1.050	194	1.000	Inparanoid score	I3828
Isobase	1	0.950	-	0	Normalized mean entropy	S4675
OMA	1	1.010	-	-		QHG57812
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000933
OrthoInspector	1	1.000	-	-		otm42568
orthoMCL	1	0.900	-	-		OOG6_101277
Panther	1	1.100	-	-	LDO	PTHR12266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1775
SonicParanoid	1	1.000	-	-		X612
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740