Protein Alignment CG12376 and SLC24A4

DIOPT Version :10

• Sequence 1: NP_610405.3
• Gene: CG12376 / 35857
• FlyBaseID: FBgn0033323
• Length: 617
• Species: Drosophila melanogaster
• Sequence 2: XP_011534738.1
• Gene: SLC24A4 / 123041
• HGNCID: 10978
• Length: 669
• Species: Homo sapiens
• Alignment Length: 733
• Identity: 149/733 - (20%)
• Similarity: 258/733 - (35%)
• Gaps: 270/733 - (36%)

  Fly    17 DNFWDTVSCYAANTFPFEERCA------FVASAKDCNRSTNVLP----YMRIMA----------C 61
            :...|.:.|.|.:.   |.|.|      ..|..|..:.|..|||    ..::||          |
Human    63 EELMDALGCGAGSP---ELRAAPGGAQDAAAGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNC 124

  Fly    62 DLNCVNEFEQVIF----------LALFMGLCYEILVLLIHVCNKYYSPALKAVSRFLCMNEHVAG 116
            ....::||...:|          |...:|..|....|.| ||:.::.|:|:.:...|.::|.|||
Human   125 TDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAI-VCDDFFVPSLEKICERLHLSEDVAG 188

  Fly   117 VTLLAFGNSSADLFSNLASV---NANVPVFANSLAAALFVSMVSGGLICYTSPFKMNAYESV--- 175
            .|.:|.|:|:.:||:::..|   :.:|.| ...:.:|:|      .::|......:.|.:.|
Human   189 ATFMAAGSSTPELFASVIGVFITHGDVGV-GTIVGSAVF------NILCIIGVCGLFAGQVVRLT 246

  Fly   176 -----RDILFLIFGSMLLQYFLASSAHVPETSFIVMFLVYIFYILVNVVDVYLIRRALKTTNAQI 235
                 ||.::.....::|..|:... .:.....:|:.::|:||||:...:|.:  :|..|.
Human   247 WWAVCRDSVYYTISVIVLIVFIYDE-QIVWWEGLVLIILYVFYILIMKYNVKM--QAFFTV---- 304

  Fly   236 DALLVGEMTPEKRKRL-------SELERNQAIYT---RDMEV----EIFERTNSGPN----INKI 282
                       |:|.:       ||||.....|.   .|..|    ::.|:...|.|    :::|
Human   305 -----------KQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVDEI 358

  Fly   283 ------RYT----------TLRMGRSTRISLDRKATRMVLH------NRALGRNWGLFKDLFIAL 325
                  ::|          |.:.|..||:   |.|:|::::      |.|.|          ::.
Human   359 MSSSPPKFTFPEAGLRIMITNKFGPRTRL---RMASRIIINERQRLINSANG----------VSS 410

  Fly   326 RPI------NCEKWR------------------------------------------KGNIIKRA 342
            :|:      |.|...                                          :|:.:|..
Human   411 KPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWV 475

  Fly   343 FMLTKIPAVIICCIYIPLVDYELDKHGWNKLLNCIQVMLNPAMSIMAIKALLSSRGNSLWYVAMG 407
            |..   |.:.:.|:.||    ...|..|.|.           ..:..|.|       :||
Human   476 FTW---PLIFLLCVTIP----NCSKPRWEKF-----------FMVTFITA-------TLW----- 510

  Fly   408 EEAIYAMYSLPITVPIAVFMFIQSRTDVPPFYHSVFTVMNLTGSMFMIFICATEIDKVLEVIGHI 472
                           ||||.:|                        |:::        :.:||:.
Human   511 ---------------IAVFSYI------------------------MVWL--------VTIIGYT 528

  Fly   473 LKVEDDFMGATVKACTGSLGPLIANVAMALHGYPRMAYASAIGGPFFTVVMSASTVMHVKNLFGL 537
            |.:.|..||.|..|...|:...:|::.:|..|...||.::.||...|.:::.          .|:
Human   529 LGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVG----------LGV 583

  Fly   538 PVSEANQTGNYGLNAFIFLNLGVFSTLLW-----STTLGFFAR-----RSVGIFSIVFYCIYLLF 592
            |........|||....|.....|:|.:|.     .|.||....     |.:|::.:|.|.|:|.|
Human   584 PWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCF 648

  Fly   593 AILIHRKVIHSFSVDLPV 610
            :|:|...|. :| |:||:
Human   649 SIMIEFNVF-TF-VNLPM 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12376	NP_610405.3	PLN03151	33..592	CDD:215604	138/697 (20%)
SLC24A4	XP_011534738.1	2A1904	<75..653	CDD:273344	140/706 (20%)