DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8584 and CTDNEP1

DIOPT Version :9

Sequence 1:	NP_610404.1	Gene:	CG8584 / 35856	FlyBaseID:	FBgn0033322	Length:	293	Species:	Drosophila melanogaster
Sequence 2:	NP_001137247.1	Gene:	CTDNEP1 / 23399	HGNCID:	19085	Length:	244	Species:	Homo sapiens

Alignment Length:	239	Identity:	111/239 - (46%)
Similarity:	153/239 - (64%)	Gaps:	11/239 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ILLSSDLGTYIRRLLARVAEKACTILRTYLGLSYREVSVSQDMAHRLAVVGRKTLVLDLDETLVH 108
            :..::.|.::...||.|   :..|::: |..:.|..:.:|....:|||.|.||.|||||||||:|
Human    14 VAFAAKLWSFFIYLLRR---QIRTVIQ-YQTVRYDILPLSPVSRNRLAQVKRKILVLDLDETLIH 74

  Fly   109 SCYLDPDTHDNVGCSQLPEHAQPDYVLNISIDGMEPIVFRVFKRPHVDEFLDFVSKWYDLVIYTA 173
            |      .||.|....:.....||::|.:.|| ..|:.|.|.||||||.||:.||:||:||::||
Human    75 S------HHDGVLRPTVRPGTPPDFILKVVID-KHPVRFFVHKRPHVDFFLEVVSQWYELVVFTA 132

  Fly   174 SLEVYAAQVVDHLDAGRGLITRRFYRQHCRASSPMVSKDLTLVTPDMSGVLIIDNSPYAYRDFPD 238
            |:|:|.:.|.|.||..|.::.||:|||||........|||::|..|:|.::|:||||.|||..||
Human   133 SMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPD 197

  Fly   239 NAIPIKTFIYDPDDTELLKMLPFLDALRFTKDVRSILGRRVIRH 282
            ||||||::..||.||.||.:||.|||||||.||||:|.|.:.:|
Human   198 NAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQH 241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8584	NP_610404.1	HIF-SF_euk	95..270	CDD:274055	92/174 (53%)
CTDNEP1	NP_001137247.1	HIF-SF_euk	61..229	CDD:274055	92/174 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176152at2759
OrthoFinder	1	1.000	-	-		FOG0002783
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12210
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1870
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.980